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GPX1

Victor ID 5314
Gene Name GPX1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23889502
NCBI Protein GI 799346519
Locus Tag CNAG_06287
Genbank Accession CP003832
Protein Accession XP_012053381
Taxonomy ID 235443
Chromosome No 13
Gene Starting Position 97424
Gene Ending Position 98806
Gene Strand (Orientation) -
Protein pI 5.24
Protein Weight 15895.81
Protein Length 151
DNA Sequence 
>gi|799350950:97424-98806 Cryptococcus neoformans var. grubii H99 chromosome 13, complete sequence
GCAGGGGATTGAGTACCTTATGGGAGGGGTCAAGAGTGAGTGTGGGGGCGGAGTCAATCTTTGTGCATAC
CCTGAGTACGTTAGCCCATAATTCACTTTTTGAGAAGCAGCAACTAGATTAAAGAATAGGGGGATCAGGC
GCTGATCTTGCTTTTGACCGCTGCTTGTAGGGAGGGGAAGACAATGGTGATGGAATATCCTCAAGGGCAG
GAAGGAGATGTGGTCAGAGGGACAGTAACAGAGTTTTAACGGGCCTATCGTGAAATGGACTGTTGAATGG
AATGGTGAAAGGATGCTGAACCCTGCAATACATACAAGTATAACAAGTTGCATGCATTTCCATTTTGAGA
CACAATTGCTCTACCTTTTCATTCAGTTGCGACGCAGGACTGCCTTATCAAAGTGCAGCCTCAACATCGC
TCTGCACCCACAAACGTGTCGGGTCAGTTTTAGCTACCATGAGGAGCTAAGGTTGGAGGGATGGTACTTA
CAACCTTGGTGCTTCGGGCAGGGAACCAGGTGATCTTTCCATCCTTGACAAGGAACTTGGAAAAGTTCTG
AGTATATGTTACTATCAGCCTCCCTTCAATTGCTTGAGGTAAAAAATGGACGTACCCAGTCGATGTCAGA
GACAGGGGGCTCGGCGTTCTCTTTGAGGTATTTCCAGATAGGCTGAGTGTTTTCGCCATTAACGTCGCCC
TGTCAAGGAGAAAAATAAATCAGCACATATTTTCCGTCACATCCACTACCAGCGTAAAATTTAGAGATAT
ATACCTTCTTGGCAATAGGAAAAGTCACTCCATAGTTGAGTTGACAGAATTGAAGAACCTCATCATCGGT
CCCAGGCTCTTGAGCCTTAAACTGCATCGGCAAACGGATCAGTCATCCGCCACCTCTTTACTTCAAACCA
CCAGGCACGCTTACTTGGTTGCAAGGGAAACCAATGATTGCCAGTCCCTTATCACCATACTTCTCGTGCA
AAGCTTGGAGATCCTTGTACTGAGGAGTCAAACCTATGGGAAAATACAATTCATCAGCCGTGAACGGCAA
ATTACTTCCCAGGAAAGAATTAAACTAACCACACTTGCTCGCAACATTGACAAACAAGAGAGTCTTGCCC
TTCAGGTCACTAAGGGGAAGAGTGGACTTGGGAAACTCAACCTGTTCGTGTCCGTCAATCGGGTATCTAG
GTGGAGAAGCACACGAAAAGAGTTGGGACCGCTGGAAACTCACAGAGTAGGAGTAGATATCAGACATGGT
TACTGTATGTATTGTCGAAAACGATTGGGCTGACACTATGGTATGTCCAATTCTAAAAAAATAGCCGGAA
GGATCGATCGATGAACGAAGAAAGATGACCGCCAGCAGCCAGCAGGTGCTGTC
Protein Sequence 
>gi|799346519|ref|XP_012053381.1| glutathione peroxidase [Cryptococcus neoformans var. grubii H99]
MSDIYSYSVEFPKSTLPLSDLKGKTLLFVNVASKCGLTPQYKDLQALHEKYGDKGLAIIGFPCNQFKAQE
PGTDDEVLQFCQLNYGVTFPIAKKGDVNGENTQPIWKYLKENAEPPVSDIDWNFSKFLVKDGKITWFPAR
STKVSDVEAAL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The mutant is sensitive to various peroxide stresses while showing wild-type resistance to other oxidant stresses and exhibit wild-type virulence in a mouse model of cryptococcosis (Missall et al., 2005).
References
Missall et al., 2005: Missall TA, Cherry-Harris JF, Lodge JK. Two glutathione peroxidases in the fungal pathogen Cryptococcus neoformans are expressed in the presence of specific substrates. Microbiology (Reading, England). 2005; 151(Pt 8); 2573-2581. [PubMed: 16079336].