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GPI8

Victor ID 5313
Gene Name GPI8
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23887934
NCBI Protein GI 799339219
Locus Tag CNAG_04525
Genbank Accession CP003828
Protein Accession XP_012051855
Taxonomy ID 235443
Chromosome No 9
Gene Starting Position 1088970
Gene Ending Position 1091323
Gene Strand (Orientation) +
Protein pI 9.49
Protein Weight 60214.87
Protein Length 567
Protein Annotation [Lian et al., 2005]GPI8 gene encoding a glycosylphosphatidylinositol (GPI) transamidase. The GPI8 gene appears to be essential while disruption of the CIG1 gene encoding a mannoprotein resulted in impaired growth in low-iron medium and altered capsule response to the iron-replete condition.
DNA Sequence 
>gi|799350821:1088970-1091323 Cryptococcus neoformans var. grubii H99 chromosome 9, complete sequence
AATTTACAACAACAATTACAATTACAATTACAATACTTCTATTGCCTTTAAGCATATATCCACGATCGCG
CCTGCCGACCCTAGTCCCATCCACCCACTATCCATTACAACTAACGCCTGCATTATTCCTCCAACAGTCG
AGCGTCCTAGGGCTCATCACCGCCCAGTGAATTGTCCTTCAACTCAGTCTCATGTCCCTTCTCGCCCGGT
TCCACAGGCGCAATCCACCACCACCACCGGACCCAAACAGCGTCAACTACACTGCAGAACATGTCGCTCT
CGCAAAGAAAATCGCCCGTCGGCAAAAGCTGTTCCGGATATTCTGGAAAAATGTCTCCAAGATACAGTCA
GTAACACCACTTCATGCAGCGGGCGTATTCATTGCCTGAGACTGATATACAAAACAGAGCTGCCTTGACA
TTGGTAGGCGTACTTTGGTTGCTAGCGTTACCGTACGAAGGACTGTGGAAGAGAACGTATGTGGATGAGC
ATGCCCTTCAGCCGGCGCAGGTTGCAGTGTACTTTGACTGGGCGAATGTGCACAAAGCAGATGTATACCT
CGCCGAGCTCGAACGATTATCGAGTTCAAACTCTACTTTTACAGAGTGAGGCTCCTCTTTAGGTCGTTAC
AGACGTTAAAGTTGACAGTCATTTGAAGACGAACAGAGTACATTCAGAACGCGTTCTCTGCAGCAGGCTT
ACATACCGGTAACACTACCACTGCAACATATGCACACGTCACGCCCCCCCGGGCTACAGGTATGGAAACG
ATCTTAGTCTCTGCAAACTGGTTATCGAGGGATGGAGGTGAGAACCTTCGAGGGGTGGCTACGCTGCTAG
CGTTGGGAGATTTCCTAAGAGGTCAGAGGTTTGGTAACTCACATAATAGTACTTTAGCTGACAGTTGGTG
TAGGCCAGAATCATTGGGCGTTTGATTTTGTCCTGGTTGTCGGCGAGGAATACCAATCGGGTCTTGCCGA
GTTTATGAAGCAGTACCACTCTCTGTTCTCTAGTGTCATCTGGACGGGTCTCAACATTGACTACCCCGGC
CACTCATTTTCCCACCTTGGCGTCTTTTACGGTGGGCCCCCTCCGTCTAATCTATAAGATCGATTCTGAT
AGTCGTCGTGTAGAGGGCACAAACGGTCGATTACCTAATCAAGATGTGATCAACACCGTCTCCAGGGTCG
CTCAATATACCGGACAAGTGCCTTTGCGATATCACAACATCCCCGATGAGCCTTTACACGGAATTGTCTG
GCTTGGAAAGTATCTGCTTGGCGCAAAGCATTTGCTTCATCATTTCGCGTATGCTGCTTTGGGCAGTGCC
AGTGCCGGACACGGTTCACTGGCAAAGTACGTACCAAAAAAGAAAAAAAAAAAGGCTCTTTAAGCAGTGT
ACTAACAACGAATAGATACCGCATCGACTCTCTCACATTATACTGTACCCCTGCAACCGGTCCTCACGGC
TTCCACACCCTAGGCCGCACCCTTGAATCCACACTCCGCTCATTCAACAACCTCCTCGAACGGCTTCACG
CCTCGTACTTCTTCTACCTCCTTCCTCGCCCCAACTACTTTATCCCCGTCGGCAACTACCTCCCTGCGGC
GGTCCTGTTGGGCGCAAGTTTAACCATCGGCGGGTTCGACTGCCCTTCCCCATTGCAAGGGCTGGTATAC
ATGTCCTTTGCGTTCGGCTCAGCACTCCTGCTTTGGATGACGAGACTACCGACATACTTGTTCTTCGCCA
CATTCCTATTCTACCCTCGTCCCCGCGGACTGGCGCACAAATCCCTGGAATCAATGTCTCTCCTCCTCTA
CGGCGCGTTCATCCCCACACTGGCGATGATAAACTTTCCTCAATCCATCCTCCTCGCATTCTTCGCTCAC
CTCTACCTCCGTCTCCCTGAATGGCCCCGTGTAGTCACACTAGCGACTCCTTGGATTATACCAGCAGTAA
TGCAGTGGTTTGGGAAAGTGGATTTGGAAAAGGAGTGGAGAGAGTTGGGGAATTTTGGGTGGGTTGGAGT
TTATGCGTTTTGGATACCGCTTTGGACGCTGGGAATCATGTTGTTATTGGGGGAGGAGAAGAAGGGGAAG
GGGGGAAGAGTTGGGGATAAGGCCGAAGGGGAGGGGAGGGGGGAGGGGGGAAAGGGGTTTGGAAAACAAT
AGAGACTAGAGGAGATTTTCCCGCCGACAAGTCGTTCGTAGGAGGATCTGATAGCCAGGATTTGGAATGT
TTTATTTCTTTTGCATGGTATGTATCAATTAGCATTTTGTTTTCCTCGGTTGCTCATAACCCCCCCCCCC
CCCGACCTCTATCGTGGCGGTATTTTTTGGATAAACACTACAAG
Protein Sequence 
>gi|799339219|ref|XP_012051855.1| glycosylphosphatidylinositol transamidase [Cryptococcus neoformans var. grubii H99]
MSLLARFHRRNPPPPPDPNSVNYTAEHVALAKKIARRQKLFRIFWKNVSKIQAALTLVGVLWLLALPYEG
LWKRTYVDEHALQPAQVAVYFDWANVHKADVYLAELERLSSSNSTFTERTEYIQNAFSAAGLHTGNTTTA
TYAHVTPPRATGMETILVSANWLSRDGGENLRGVATLLALGDFLRGQNHWAFDFVLVVGEEYQSGLAEFM
KQYHSLFSSVIWTGLNIDYPGHSFSHLGVFYEGTNGRLPNQDVINTVSRVAQYTGQVPLRYHNIPDEPLH
GIVWLGKYLLGAKHLLHHFAYAALGSASAGHGSLAKYRIDSLTLYCTPATGPHGFHTLGRTLESTLRSFN
NLLERLHASYFFYLLPRPNYFIPVGNYLPAAVLLGASLTIGGFDCPSPLQGLVYMSFAFGSALLLWMTRL
PTYLFFATFLFYPRPRGLAHKSLESMSLLLYGAFIPTLAMINFPQSILLAFFAHLYLRLPEWPRVVTLAT
PWIIPAVMQWFGKVDLEKEWRELGNFGWVGVYAFWIPLWTLGIMLLLGEEKKGKGGRVGDKAEGEGRGEG
GKGFGKQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: GPI8 gene encoding a glycosylphosphatidylinositol (GPI) transamidase. The GPI8 gene appears to be essential while disruption of the CIG1 gene encoding a mannoprotein resulted in impaired growth in low-iron medium and altered capsule response to the iron-replete condition [Lian et al., 2005].
References