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GLR1

Victor ID 5309
Gene Name GLR1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886023
NCBI Protein GI 799331197
Locus Tag CNAG_02399
Genbank Accession CP003825
Protein Accession XP_012050124
Taxonomy ID 235443
Chromosome No 6
Gene Starting Position 423778
Gene Ending Position 426476
Gene Strand (Orientation) +
Protein pI 6.57
Protein Weight 48451.18
Protein Length 479
DNA Sequence 
>gi|799350727:423778-426476 Cryptococcus neoformans var. grubii H99 chromosome 6, complete sequence
TACCACTCTCTGTATTGCTTCGTTGTACATCACTTATTACTAAGTCGACCGACTTGCTTTGTCATCGCCT
TGGGTCAAGCGAATGGTGCTTGATGAAAATTGGGCATCCATAACCTGGATCCCGAGCTTATTTTTGGCTT
TCGCGGCATAAGGGTGAGCCAGAATGCCCCATGTACGTAGTATAAGTTGGGCATATCAGCTGAGATTGGA
ATGTGACATTTTTGTAGTTTCGTCATTCATTTATTCCTCTGTGAATTCGTTCGTTCTTATAAATCACATC
CGTATTAGCTTTCAGTTTCCTCCCCTCCCGAAACATATTCAAGGTGCCGCCTTTCAACTCCCTCTCCAGA
CTCTCACTCGGTACGGTCCGTCCGTCATCCAGACAAGCTATCGCAGTTACCGCCACAGCCATCCGCTCTT
TCAATTTCTCCAGACAACCTTTCCATTACTCAGCTACCAGGACTTTCGTCAGCACTTCCATCGCGAAAAT
GCCTCCCATCAACAAGGCTCAAGCTGAACAAGCCGGAGAATAGTGAGTGAACGTGGATTGTGAACATTCA
GGCGAAGGTCATTGATCAGTCATGCAGCGACTACTTTGTCATCGGTGGTGGTTCCGGTGGTCTTGCCTCT
GCTGTGAGTATACATTTTAGAGCTATTTATTATCTGAACCATCTACATGGCCCCAAAGACACTAATGGTG
TCGACAGAGGCGAGCCGGTTCTTACGGTGCCAAGGTCGGTCTCGTTGAGGTTTCTCCTCGACTGGGTGGT
ACTTGTGTGAACGTCGGGTGAGTTAAAGCAGCATGTCGCCCCTTGTCAGATGATATAAAGGCTAATGCCT
GCATTACAGTTGTGTACCCAAGAGTATGTCTATTATGAAACCCATCCTATAAATAAACAACTCACGATAT
AATAACCTTTGTCGTGCCGTCCAGAAATCATGTGGTGTGTTCAATCTATTAAATTTATTCCCCATGAGGA
CTGACATTCCCATAGGTATACTGCCGATGTCGCCGAGAACCTTCGAAAATCTGCACAGTACGGCTTTGGC
AAGGAGGGTGAGGGCTTCAAGCTCGCTGCTGACTTCAACTGGACCGAGCTCAAGCACAAGCGAGACGCCT
ACATCCATCGTCTCAACGGTATTTAGTGCGTCAAGCGTCATTTTTCATATCATTACTAACGATATCTGCG
ATAAAGCGAGAGCAATCTTGAGAAGGACCGCGTCGATCACCATCAAGGTTGGGCTTCTTTTGTTGATGCC
AACACCGTCCAGATCGAGCCTCCCAATGGCGACAAGTACACCGTGAAGGCCAAGCACATCGTTATCGCTG
TCGGTGGCCGACCCACCGTCCCTTCAGAGAAAGAAATCCCCGGTGCTTCCTACGGCATCACTTCAGACGA
ATTCTTTGAACTCGAAACTCAACCCAAGAGGGTTGCAGTCATCGGCGCTGGTTACATCGCGGTGGAGTTG
GCTGGTGTCTTCAATACCCTCGGCTCAGAGACCCATTTAGTTATTAGGCACAACGAGCTTTTGAGGACCT
TTGATCCTATGATGTCAGAGGTCTTGGTTCCTTGCATGGGTATGTCCTATTTCACGTTTATGTGAATCAG
ATGCTGATCATCTGACAGAGAAGGCCGGCATGAAGATTCACAAGAAGACTCATGTTAAAAAGGTTGAGAA
GACTTCTTCTGGCTCGCTTCTCGTTCACTTCGACTCCTCTCCTGAACCCATTGAGATTGACTGCCTTCTT
TGGGCTATTGGCCGACACGCTGACACTGCCAAGCTGGGTCTTGACGAGGCCGGCGTGAAGTATGATAAAA
GAGGCAATGTCATTGTTGACGATTACCAGAACACGAACGTTCCTGGAATCTATGCTGTTGGTGATGTAGG
AGGCAGGATGTTGTTGACCCCTGTGGCTATTGCTGCTGGAAGGAGGTTGAGTAACAGGTTGTTCGGCCCC
GAAAAATATAAGAACGACAAGTTGAGCTACGACAACATCCCTAGTGTCGTCTTTTCGTAAGTAATCTTAG
TAGGGCCTTGATAGGCGGCTAAAAATTTACATCTTCCCTAGTCATCCCACTATCGGCTCCATTGGTCTGT
CTGAGCCTGAGGCCAGAGAGAAGTTTGGTGACGATAACATCAAGATTTACAAAACCTCAGTGAGTTCTCC
ATTGATTACGTGGCGCTCCAGGTTCTGGAACTGATGGCTGTCGACAGTTCCGCGCCATGTCTTTCGCCAT
GCTTGATGAGGACCACAAACAACCCACAGCCTATAAGCTCATTTGCACCGGTCCTGAAGAGAAGGTCGTC
GGTCTTCACATCATCGGTGAAGGCAGTGACGAGATGCTCCAAGGCTGTGAGTATTTCTTGAATAGGCGGT
AATCGTGAAATACTAACGAAATGTTCTAGTTGGCGTCGCCATTAAGATGGGCGCTACCAAGGAGGACTTT
GACTCTTGTGTTGCCATCCGTACGTCTGCAATAGATGACGCGACCTCCTTAGCAGCTGCTGACTTACCGT
TAGACCCTACCTCTTCCGAGGAGCTCGTTACCCTCCGTTAAATATAGAAGCAGAAGTATAGTTGGTAGAT
GAATGCATACAATTCGCGATAGTTGACAGTCCACAATGCCGAATGCTATGAATGTTATTATTTGTTATAG
GTTATTTACTACAAGCATCTACCTTACACACATACAATA
Protein Sequence 
>gi|799331197|ref|XP_012050124.1| glutathione-disulfide reductase [Cryptococcus neoformans var. grubii H99]
MPPINKAQAEQAGEYDYFVIGGGSGGLASARRAGSYGAKVGLVEVSPRLGGTCVNVGCVPKKIMWYTADV
AENLRKSAQYGFGKEGEGFKLAADFNWTELKHKRDAYIHRLNGIYESNLEKDRVDHHQGWASFVDANTVQ
IEPPNGDKYTVKAKHIVIAVGGRPTVPSEKEIPGASYGITSDEFFELETQPKRVAVIGAGYIAVELAGVF
NTLGSETHLVIRHNELLRTFDPMMSEVLVPCMEKAGMKIHKKTHVKKVEKTSSGSLLVHFDSSPEPIEID
CLLWAIGRHADTAKLGLDEAGVKYDKRGNVIVDDYQNTNVPGIYAVGDVGGRMLLTPVAIAAGRRLSNRL
FGPEKYKNDKLSYDNIPSVVFSHPTIGSIGLSEPEAREKFGDDNIKIYKTSFRAMSFAMLDEDHKQPTAY
KLICTGPEEKVVGLHIIGEGSDEMLQGFGVAIKMGATKEDFDSCVAIHPTSSEELVTLR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The glr1Delta mutant is sensitive to nitrosative stress and macrophage killing in addition to being avirulent in mice (Missall et al., 2006).
References
Missall et al., 2006: Missall TA, Pusateri ME, Donlin MJ, Chambers KT, Corbett JA, Lodge JK. Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. Eukaryotic cell. 2006; 5(3); 518-529. [PubMed: 16524907 ].