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FRR1

Victor ID 5305
Gene Name FRR1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886292
NCBI Protein GI 799320765
Locus Tag CNAG_02729
Genbank Accession CP003822
Protein Accession XP_012047918
Taxonomy ID 235443
Chromosome No 3
Gene Starting Position 889999
Gene Ending Position 892363
Gene Strand (Orientation) -
Protein pI 9.88
Protein Weight 68011.1
Protein Length 646
DNA Sequence 
>gi|799350639:889999-892363 Cryptococcus neoformans var. grubii H99 chromosome 3, complete sequence
TTTATCCCCATAATCGAGTACACATACATTTTTCAAGATACTACTACAACTAGCTAGAAAGCCATATGAT
TCTTCGAGGCCGCTCTCCCATCGAGGGCGCTCGATGACATGAGAGCATAATACAAACAACAGCACTCAAC
AACAGCCCTTTTATTCCTTTCTATTTTCAAACTACATTTCTTCGGAGATTACTTTTATGAATTTCCCCCA
CCTTTCGACGCATTCGACTATTTGTTCGTAAGCGCGCTTCCGTCCCTGATAGACTTTGATGAGAGGAAAA
ATCTCCCTGTGTACTGATCCACAATCTTTACACTTCATTCGCACCCCCTCGTACGCCTGTTCACTCAATG
GATGTGAAGCGCATCGCTCGGAGAGCTCAAGATGTACCAATCGCTCCCAACGCTTCATAGCCAACAGGGG
CGGGGTTCGATGCGTGGTTGCCCCGGGGAGGAAGGATGTTGTCAAGGTATCGGAGCGATGCAATGAGGAG
GTAACATCATGACGTGAGCGGCCAGAGGGGCGAGGAAATATGTCAAGAAGGATGGGTCTTTTGGATTGAC
ATTCTAACTAGGCATCAGTCAAGGAACTATTGACCTAGAAGTTCAAGAGCTTACGGTTGGTCCACTGACC
GATGCGTCTTGGGACATTATCTGTCCTTCCGACTTTGTAGAATGAAAGCTCGCTGGTTTCCAGGTCTGAA
AAAAAAAAAATCATATTAGTTCGATTAGAACACACGCCTCAGTTTCTCCTACCCTTAAGCTCATAAGCAT
ATAAGAAACCAGCACACTCCTGTGATATGGCCTGCGTCAGTGCTTAAATCGCCATTGCAATCGTTCTTTC
GTCTACCTTGGGTGTCAATTTAGTTTCCATAGTCATCCTTAATAACGTTTGGGTTTGCTGTCCCAGAGCT
TGCGGTATATAGTCTAGGCGATAATTAGCTGGCGACTTTGCACAACTAGCTTGTCTCACCATCAAATTCA
ATCCAGACCCCAGAACTATCTCGTTCCCTTCTCCAGTAGAAACCCTTGATGGTACATATCATACCTGCAT
GGTCTTTACAATATCTTCCCATCACTTTCTCGCTTCTTGCATCTCCACTGTCCTCGTCCAAGGCCACTGA
GGCATCTGGAGCAGACAGGTAGGGAGCTTTGACCCTGACCAGCCGCTTGCAAGGTTGACCCGTACGAGTG
AATCCGGAACATTGTACAGAGCTTGAATTTGACGTATAGGGCTTGTGTGGGGAATTTGACTTTTTGGTCT
TACTGGGTGGGATGGAGGATGGGGTACTGGAGGAGCCCCTCCGGGCCGGAGAAGTAGACAGAGGTGATGG
AGAGGTTAGGAATGAATGCCTCAAATCTGGTGTTGCCTTCATAGGCGTAGTGGATGATCGCGGTGTGACA
TTTTCTTTTGCCAAACCCGATGGGGGTGAAGCTGAGGAGTCTGAAATTTGAGTCAAGTCGATGACCGAGT
CACGTTGGGCATCTTCAGGGGTTGAAAAGGACTGAGAGGTCTGAAGCGATTTGCTTTTCGGTGCGCTAGA
CTTGCTCGAAGAGTTAATCTCTTCTTTGTTGTTGGCGGAGCTTGCCTTGATACCTTTCCCGTTTACTGAA
GCCTTGACTGGATGTCTCGCGTGCGGGGGCGTTTTGGAAAACATAGGCGCGTTTATTACGCTCAAACTGA
GGTCGACATTTCTATATGTATTTGAAGTTGGTCTCTCCACTACAGCAGGTCCCTTGTCATCTCGAGAAAC
TTCAAAGCCTGACACTTGCCCTGAATGCAATGACTCCACCGCGGGTATAGTCTGAGATGGAAAGCTGCCT
TGAGAAAAGGCAGTCACGTTTGGAAGACCTGCATTATGGTGGTTAGGCGGCACAATATCAGGCCGAGGTA
AGGGGGGAAGCTGTTTGTTGCAATTGGGAGATGCAGAGGACGGGCGCGGAGCAGCTCTGTGCGTTTTGCT
GAAGTGGTCAGGGACTTGAGATGGTCGGTCGTTCAGTTTGACTCCATCGTGAAGTTGAAGATTGTTCACT
GAAGTTGTTAAGCTGAGGAGATACTCGTTGCCTCTACTCCTGAGCGCCTGAGCGGCTATTGCGGCTTGCG
GAGAGGATTGAGACGGAGAGTAGGAAATAGGCGGATGGTACTGAGGACTACGATGATGGCTTATTGGTGG
TGGATGGTAAGGTGAAGGATGAGCGTTGTGGGCGTTGCTTGGAGAAGCTGTTGTATTCGGCCAATAGAGC
TGTCGTTGATAAGGGCCGGTCGGGTGGGGCATGTTGAGCTCTGAGGCTGAAAGAAAAGTAGAAACGAGAC
AAGTAAGGATCATTTAATGTAAAGTAATGTGCGAGGTCGAAAGGCCAACGGCCGA
Protein Sequence 
>gi|799320765|ref|XP_012047918.1| hypothetical protein CNAG_02729 [Cryptococcus neoformans var. grubii H99]
MILTCLVSTFLSASELNMPHPTGPYQRQLYWPNTTASPSNAHNAHPSPYHPPPISHHRSPQYHPPISYSP
SQSSPQAAIAAQALRSRGNEYLLSLTTSVNNLQLHDGVKLNDRPSQVPDHFSKTHRAAPRPSSASPNCNK
QLPPLPRPDIVPPNHHNAGLPNVTAFSQGSFPSQTIPAVESLHSGQVSGFEVSRDDKGPAVVERPTSNTY
RNVDLSLSVINAPMFSKTPPHARHPVKASVNGKGIKASSANNKEEINSSSKSSAPKSKSLQTSQSFSTPE
DAQRDSVIDLTQISDSSASPPSGLAKENVTPRSSTTPMKATPDLRHSFLTSPSPLSTSPARRGSSSTPSS
IPPSKTKKSNSPHKPYTSNSSSVQCSGFTRTGQPCKRLVRVKAPYLSAPDASVALDEDSGDARSEKVMGR
YCKDHAGMICTIKGFYWRRERDSSGVWIEFDDYIPQALGQQTQTLLRMTMETKLTPKECAGFLYAYELKD
LETSELSFYKVGRTDNVPRRIGQWTNQCQSKRPILLDIFPRPSGRSRHDVTSSLHRSDTLTTSFLPGATT
HRTPPLLAMKRWERLVHLELSERCASHPLSEQAYEGVRMKCKDCGSVHREIFPLIKVYQGRKRAYEQIVE
CVERWGKFIKVISEEM
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: This gene encoding the C. neoformans FKBP12 homolog, Disruption this gene conferred the fungi Rapamycin resistance (Cruz et al., 1999).
References
Cruz et al., 1999: Cruz MC, Cavallo LM, Görlach JM, Cox G, Perfect JR, Cardenas ME, Heitman J. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Molecular and cellular biology. 1999; 19(6); 4101-4112. [PubMed: 10330150 ].