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FRE3

Victor ID 5304
Gene Name FRE3
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23889716
NCBI Protein GI 799333819
Locus Tag CNAG_06524
Genbank Accession CP003826
Protein Accession XP_012050663
Taxonomy ID 235443
Chromosome No 7
Gene Starting Position 7045
Gene Ending Position 10252
Gene Strand (Orientation) +
Protein pI 9.78
Protein Weight 68412.49
Protein Length 653
DNA Sequence 
>gi|799350762:7045-10252 Cryptococcus neoformans var. grubii H99 chromosome 7, complete sequence
GCTGCGGAGAAACGGCCGAAAAACTTCAGGCACTGAGGCATCTTGTGCCTCAAAAGTGGCACACAAACGC
CTGTAGCCTTACACGGCCCCCTGTCGCCTCCCGTATCGTCGTTAGGGATCGCCATCTTTGTTTGCTGCAA
TATTCCTTTTTTCTTTTTTTCCCTCTCGTCCTCGTTGCAGAGCAACGGTTTCTGTTTGGCTCGGGGGTCA
GAAAACCTTGCCGGAACGCTGCGGAACGAGCAAGAACGTCGCAAAATGTAAACTCCAATCGGCCGATTGC
GTCTCGTGAATCAAGCAGGTTGCCAGGAAAAGCAAACAGGTGGACCTGCATTGACACGGGAAGCAGGCAT
ATGAGAATTTTTCCCAAGTAGATAAAGCATGAAGCGCGAACAAGTGCAAGAAGACCCACATCAAACGTCC
ATACATCTTCAAGGAATCACCAACGCCCACTGAGGCATTTTCAAAAAATGTCGACCACACACTACCACGG
TTCGACGTCCGATTCGTCTACCACGACCAACTCAACTACCGTCTCTTCTTCGTCCAACTCAACTTCGGCG
GTCTCTTCGTCTTCCAACTCGACCTCATCCTCCTCGTCCGGTCACCGGTCGAGCGGCTCTTCATCAACAT
CATCCACAAATAGTAACAATGGCAGTAGCAGCGGCAGCGGGTCCAACAGAGAATCCGCTGTGCGGAGTAA
CGATCCTTATCCTCAAGTCAAGTGGATGTGGACCGCGATCTGCGGTGTTGTCATCCTTTTGGCTATTTGG
TACCTCCTCAACCTGTACAAAAAACTCAAGAGGCAGAACTCCAAACTAGCCAACAAGGAATCTGGTCGTC
CTTACAAGCCTAGCAAATGGGACGCGATCCAGGTCGGCGCTAGAAACTCTTTCATCGCCCGGGGCTTTCC
CAAGTGGCTTTATGCCCCCGAGACTCTGGCCGACGCTCTTTGGACCACCATCTATTTCCTGGTTACTGTC
ATCATCACCTTGTACGATGGCCCATGTAAGTGAACGGACACTCCCACATTGTCGTATTAGAGAGCTGACA
TTTGCGATATCAGGGTCTATGGGACAGGTCAACGTCTCCAACGCTTTCGGTACTATTGTGAGTGTTTCCA
AGTTGTTTTTGATGTAGTGATACAGTGACTAATGCATGCCACGTGATTAGGCATACGCTCAAACTCCTTT
GATCTTCTTCTTCGCCATGAAGAACAACCCCATCTCTTGGCTCACTGGCATCCCTTACCAGAACTTGAAC
TACCTTCACCGAGCTTCCTCCCGAGCGATGCTTGTCTGGAGTTGGCTCCACACCGGTCTCGCCATTGCTC
AAGTGTAAGTCAGGCCGGACTGCCGTCTGATCTGTCGCCACTGTAGCTGACACTCCGTCCCCGCCTTTTC
AAGTAAACAGCGCAAACAATGGGCCGACGCTTACATCATCTGGGGTTGGGTGGCCATGGGCGTCTTCACC
ATCATGTGGCTCGCTTCATTTGCCACCATCCGTCGTAAACTCCACCAGCTCTTCTTCGCCGTTCACATCG
TCATGGCTGTGTCAGTGCAATCTCTTAGGGCCTGTTGATGGATCGTCCAGCTGACAATACGCAAACAGCT
TGTACCTAGTTGCATGCTATTTGCACTGGGCCACTCTTGGGTTCTGGCTTTACGTGAGTCATGATTGTCT
TTCATCGATGCGATCAGGTGAACTGACAGGGTGCCATTTACAGTCCTGCTTTGTCATCTGGGGCTTTGAC
CGACTTGTGCGATTCGGCCGTACCATCTACTACAACCGGATCTGGAGCCAAGGTCGAGGTGAGTGCAAGA
TCGAGATCCTCGACGACAGCTGCTTGCGTATCACTGCCATTCGACCCGGCTTCAAGTGGGGACCTGGCCA
ACACGCGTAAGTTCAACGCTCAATTAGACTCAGACCAAGCTCATTCATCTGGACACCAGCTTCCTCACCT
CTCCTCGACTCTCCAAATGGGGTATTGCTGAGGCGCACCCCTTCACCATGGCCAACGTTCCCAACGATGC
TGGCGAGGTCATCATCTTGGCTCGTGTCTACCAGGGTGAGTCTAGTCTGCCATTTTGAGAGCGAACAGGT
GCTGATGATCTTTGGGCAGGTTACACCAGGCAATTGACCAACAGCTTGACCGCCAACAAGGACAAGTTGA
TCCGATGCTACCTCGATGGACCTTACGGCTCCCCTCACAGCTTGGCCTCTTACGACTACGTCACTTTGGT
TGCTGGTGAGTTGCCGCGATTTAGATATCATTCAACTCCTGGACAGAGCTGACATGTACCCTACAGGTGG
TACCGGTATCGCTCCTTGGACTGCTCATCTCGCCGGCCTTCTTGCCGAGCGAAAGCCAATCCGAACTTCA
TACATCCACATCGTCTGGCTCATCCGTGAGGCGACCAATGTCAGCTGGATCGCTCCATTCATTGAGCAGA
CTGCCGAGAAGCTCCGAACCAGGTCCGACATCACTGTCAAGTTCAGCCTTCACGTCACCCGAGGTCAGAT
CCCCGCTCAAACCGAGAAACACACTTCTATCTCGGACGAAAGCGCCTCTCAGGCCAGCACCCCTGCCATT
GAAGAGATGCCTGCTCTCACTCACAAAGCCGAGCCCGTCGCTGCCGATGTCACATTGACCAAGACCAACA
AACCTGCTGTCCTGCTCTCTCACGAGGCGAGTAAGATCGTCGAGTGGCACCAGGGTCGCGCTATTTTCGC
CGACGTCTTCAGCGCGGATGCTCAGACCTGTCCCGAGGCCATGGCTGTCGGTGGTAAGTTTTGCTCTCCA
TAGTTGGGCACGCAAGTCCAGATCACTGACCAATGTCACACTCATAGTCTGCGGTCCATTCCCTCTCATG
GAGTCGGTCCGAAAGGGTGTCAGGGAGGCATCGACCTTCCGCTCCGTCCTCAGGGGTCAAGTCCCAATTG
ACTACATTGAGGAGACTCTTGGTCAATAAATTTGAGATGACCTGGTCTAAATACGATGCAGGGCAAGTGT
ACATTCGGGCAGTAAATAGCGAAATTGATTTACAGCATGATTCGTCAGTATGCGTGCATGAACAATGCAT
GAAATGAGCTATGCAAGATGTCAGTAATATTTTCATCAAATAGGAGCGCTGTAGGAGGTCGTATGCAGTC
ATAGTGTGATGAAATAATTCCAATGCATGCTGCGTCGTTGTCGTCGTCGAAGAGAAAA
Protein Sequence 
>gi|799333819|ref|XP_012050663.1| hypothetical protein CNAG_06524 [Cryptococcus neoformans var. grubii H99]
MSTTHYHGSTSDSSTTTNSTTVSSSSNSTSAVSSSSNSTSSSSSGHRSSGSSSTSSTNSNNGSSSGSGSN
RESAVRSNDPYPQVKWMWTAICGVVILLAIWYLLNLYKKLKRQNSKLANKESGRPYKPSKWDAIQVGARN
SFIARGFPKWLYAPETLADALWTTIYFLVTVIITLYDGPWSMGQVNVSNAFGTIAYAQTPLIFFFAMKNN
PISWLTGIPYQNLNYLHRASSRAMLVWSWLHTGLAIAQVKQRKQWADAYIIWGWVAMGVFTIMWLASFAT
IRRKLHQLFFAVHIVMAVLYLVACYLHWATLGFWLYSCFVIWGFDRLVRFGRTIYYNRIWSQGRGECKIE
ILDDSCLRITAIRPGFKWGPGQHAFLTSPRLSKWGIAEAHPFTMANVPNDAGEVIILARVYQGYTRQLTN
SLTANKDKLIRCYLDGPYGSPHSLASYDYVTLVAGGTGIAPWTAHLAGLLAERKPIRTSYIHIVWLIREA
TNVSWIAPFIEQTAEKLRTRSDITVKFSLHVTRGQIPAQTEKHTSISDESASQASTPAIEEMPALTHKAE
PVAADVTLTKTNKPAVLLSHEASKIVEWHQGRAIFADVFSADAQTCPEAMAVGVCGPFPLMESVRKGVRE
ASTFRSVLRGQVPIDYIEETLGQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: FRE3 was shown to express an iron reductase activity and to play a role in iron-dependent growth of C. neoformans. Overexpression of FRE3 in the two original environmental strains increased growth in the macrophage cell line J774.16 and increased virulence (Hu et al., 2014).
References
Hu et al., 2014: Hu G, Chen SH, Qiu J, Bennett JE, Myers TG, Williamson PR. Microevolution during serial mouse passage demonstrates FRE3 as a virulence adaptation gene in Cryptococcus neoformans. mBio. 2014; 5(2); e00941-00914. [PubMed: 24692633].