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FBP1

Victor ID 5303
Gene Name FBP1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888606
NCBI Protein GI 799325215
Locus Tag CNAG_05280
Genbank Accession CP003823
Protein Accession XP_012048824
Taxonomy ID 235443
Chromosome No 4
Gene Starting Position 920416
Gene Ending Position 923953
Gene Strand (Orientation) -
Protein pI 8.54
Protein Weight 97065.62
Protein Length 928
DNA Sequence 
>gi|799350666:920416-923953 Cryptococcus neoformans var. grubii H99 chromosome 4, complete sequence
TGACGAGAAAGCACACGTTCGCACAGTATAATCTCTTTCCATCCTATCATTTCCTAATACACATTATTGG
ATGCAGGTTTAATGCTGGCATACTCGAACGCGCTATCTCCAATAACGTCATTAGCCCGCTTAAATTCTGG
GAATCGTCACTCTACATAGAACATATTTATCCAACAACTTTCCTGCTATGCTGCTTTGTATGAATCGTAC
TTTACTGAACAACATGACGCCAACCTCTTGTTTTGTACACATATTTCAACCGCCCCTCTGCCGCACACCA
TTACGACAGCCAATCAACGTCCGTTACCGAATCGTTGTAACCATCTTGGACCCCTTCCTCCTTCCCTTTG
AGCGCCCGCGCTCGATGATAATGATCCATTCGCGCTTGAACGTTGAGACAAATTTGCGACTTGAGTCATA
TGTTCTTCAGCACTATGCGCACGCGTTATCCCGATTCCTGAATCTGATGCTCGTGGTAGCCGCCCCTCCC
TCGGCCAATATGTTGTGAATTCGTTAGCATATGATGGCGACACATTATACGAGCCCGATGGCACCCTAGG
TCCAGATGGTCTATCCCTCCTACCCTGCGCATCTGGGCCTCGGCTGCGATCAGACACCCCTTGATGCGGA
ATGAACGGGAGCCTATCCCCGTTTGAGCTTATACTGGATGATCTAGAAGATTCCTGAGAAGGAGGTACGA
GGTAATCCAAATGGGGAGGCAAGGTAGTATCACCATAGGCAAAGCGATTATGTAAGCTAGGACTTAAGCT
GATATTGAAATATGATGGAGTGGCAGACGTCAGGTTGGAAGTAGGCCTAGCAGATGACGAAGACATGAAA
GCGGGAGGTGAGGTAGACGTCGACGCGATAGGGAAGGGAGCATTTTCACCAGGTTGAGCGCTTTGGTATT
GGATCGATGTGGTAAAAAGGTGCGGTGGTTGAGGTCGAGACATAGGGGTGGGAGAGATAGGGGGTGCAGC
GTCTTCCCAAGCATCATTCAGATTCGATAACGACTGCCTATACACAAGGTTGTTGTGTTGAAGAATGCTG
TTTGAAATTGATGAATGATCGGGGGTGGGTGCAGCCCTGGGGATGGTCAAGGATGAGGTACTGGAAGCCG
CACCGTCGTGGCCCGAATCTTCAGAGGTGTCAATTTCCATCGAGGGAAGATAGTGGTTATTGAGGTAATC
GCGAAGCTCGACAACTCTTGAGCCGGAGAAGACGCAGAATGCGGCCCGTTGATGATCGTTGAAGAACTAA
CGTGGAAATGAGCTTGATAATCAAAGCATATCTTTAAAGAATACTCACGTCTGGGGGTGGACGGCAGAAT
TCCTGGAGTTCCGGGACCTTGAAAGAGCTCACACCTGTAAGACTCAGGTGCTTAATGTGAGCAAGTTTGT
TGAGAAGGTATGCAATCGCCTTAACGCTAAGCTGGTCACAGTACGATAAATGCACCCGCTCTAAAGAGGT
ATGCTTTCTGACAAGAGAATATATCGCTTCGTCAGTGATATTGGTAACCTGTTGAAAAAAGTTTAGCACT
TGAGACACTGACTTGACTCATTGGGACATACCTTGACCAAACCAAATCTCTTCAGCTTTGGCATATTTTC
GCCAATCTCAGCCACGCAAGCATCGGTCAACAGAGTGCAACAAGCCAAGTCAAGGTAGCGTAGTCTGGTA
CATGATTTCGCTAGGTTGATAACCCCATCATCGGTGATTCTGTAGTTCAGTCAGTTTGTTTTTACTGTCA
CGCTCGCCATGCTGAATGCTGAATACTCACAAGCTGACATGTCCCAAATGCAAGTTATGCAAGTGCTTCC
CCAGCTTTCCAATACTTTCCAAACTTTTATCAGTCAACGCGGGGCATTTGTTCAACGTCAACTGCCTCAA
TTTTGGGGCATTGGTAATCAGGTTATCAACCGCTTTGTCACCCAGATCCGTACACCCAGTCATATCAACC
ACCCTCAAGTACTCAAAAGTGGTCGTCACCGGTCGCAACATCGTCACGCCTTCCGCAGGTTCGACTTTGA
TCCCCACATCTTCTGACACTTTGGCAATCCAGTCGTCTTGCATTTCGCTCAAATCGAGCAAATTGGGTAT
ACAATTTTCGTCGAGGGACACGCAGCCATTCACACGTAGTTCACGGAGATGAGAGGCGTGCAGGAAGACA
GTGTGAAGGACAGAAGAGGATAAAGAAATGACATCTTGCAAGTCATATTCCAAAACAAGGGGGCACGCGC
GGATAAGAGGAATGAGTGATTTTTGTGTTATTCGATGACATTTGTCAAACTTGATCTAATGCCACGGTCA
GCGATTTCCTGACAATAAGCGGAAAGTACATACCCTGCGGAGCACTCTGCTTTCCTTCGCCAGTGCCAAG
ACACCCTCATCCCCGACCAATCTACATTCGGACAGATTGATAGCTTGCAGCTTCTTGCAGGTCTCACCCA
CAACCACCAGGACGGCATCGTCGGTGTTAATGACACCTGTCAAATCCAGGGACACCAGATTTGGCACACA
GGCGATGACATTTCGCAAAGCCCCGGATGTGAGCTTGTCAGCACCACTAATATTAAGCCTTTCCAGTCTA
GAACACACTGATAGAGAGGTGAATAGCTCATCAGTGAGAGTTGGACCTAGTTGGATGAGAGGCAGTCGTC
TGATGGCGTTGGCGTAAGGTAGGGATCGGGTAGGGGAATGAATTACACGAATAATCGAGGCGAGTTGCGT
GATTGTTGGAAGAGTGGGTTTGTACCATAATAATGAAAAGGCACAAAGACACCAAAAACGGGATACCAAA
AGGACAGACAGGAGATCCTTGTTTCCAGGTAGGTACCGGAATATCTGAATCAGGATCTCGGGCGGCAGTT
GGTTCGTCAGATCGTTCTTAATTTCACCCCTTTTATTGACACCCTTGTACTTCCCGTTTCTCTTCCATCC
CCGTCCATCGCGTAGCTCCAACCAGCTCTTCGCCTCCTCGTCTATACCACCCCTTCCACGCTCGTCCTGA
TCATCTTCATCGTCCGTGCTTGCCGCGGACGGTGTTCTGCTCGTATTTCTAAGCACTTGAGATCTTATGT
GGCGAGTGTATTTGGGGTCGCGAGTCACCTGAGGCGCAAGTCGGGGGGCCTTAGGTGGGGTGAGAGATCT
GTCAAGAGAGAGTTGGTTGAAAGCATTAATGGGTGATGTTTCTCTTTCTCTGATCGATGTAGGGCGGTAG
GATGAAGCCGGGGATGAGTTTGCCACGTGGCGTATAGAAGAATCCGAGTTGCTTCTTGACGGTCGTACGG
GCATGTTGAGGGTTGTTGATAGAGAAAATGAATGACGACAATAGTCTATATATCGTACGGCGAGTGAGTT
CGGACTGCCGGCGGAAAGATGAATAGATAGTGATTGCAAGTCTAGATCGTAGGGTATTTCCCGGTCGTCA
ACCCCTCTCTTTGTACTGCGTGAGTCGTCGGGATATCAGGATAGGTTGGCCATAGTAGGTGGAAGAGATG
ATTTAGAAGTAAAGTATGGATGAGGATGAGAATTTGAG
Protein Sequence 
>gi|799325215|ref|XP_012048824.1| F-box and leucine-rich repeat protein GRR1 [Cryptococcus neoformans var. grubii H99]
MPVRPSRSNSDSSIRHVANSSPASSYRPTSIRERETSPINAFNQLSLDRSLTPPKAPRLAPQVTRDPKYT
RHIRSQVLRNTSRTPSAASTDDEDDQDERGRGGIDEEAKSWLELRDGRGWKRNGKYKGVNKRGEIKNDLT
NQLPPEILIQIFRYLPGNKDLLSVLLVSRFWCLCAFSLLWYKPTLPTITQLASIIRVIHSPTRSLPYANA
IRRLPLIQLGPTLTDELFTSLSVCSRLERLNISGADKLTSGALRNVIACVPNLVSLDLTGVINTDDAVLV
VVGETCKKLQAINLSECRLVGDEGVLALAKESRVLRRIKFDKCHRITQKSLIPLIRACPLVLEYDLQDVI
SLSSSVLHTVFLHASHLRELRVNGCVSLDENCIPNLLDLSEMQDDWIAKVSEDVGIKVEPAEGVTMLRPV
TTTFEYLRVVDMTGCTDLGDKAVDNLITNAPKLRQLTLNKCPALTDKSLESIGKLGKHLHNLHLGHVSLI
TDDGVINLAKSCTRLRYLDLACCTLLTDACVAEIGENMPKLKRFGLVKVTNITDEAIYSLVRKHTSLERV
HLSYCDQLSVKAIAYLLNKLAHIKHLSLTGVSSFKVPELQEFCRPPPDFFNDHQRAAFCVFSGSRVVELR
DYLNNHYLPSMEIDTSEDSGHDGAASSTSSLTIPRAAPTPDHSSISNSILQHNNLVYRQSLSNLNDAWED
AAPPISPTPMSRPQPPHLFTTSIQYQSAQPGENAPFPIASTSTSPPAFMSSSSARPTSNLTSATPSYFNI
SLSPSLHNRFAYGDTTLPPHLDYLVPPSQESSRSSSISSNGDRLPFIPHQGVSDRSRGPDAQGRRDRPSG
PRVPSGSYNVSPSYANEFTTYWPREGRLPRASDSGIGITRAHSAEEHMTQVANLSQRSSANGSLSSSAGA
QREGGRGPRWLQRFGNGR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Fbp1 mutants showed normal growth and produced normal major virulence factors. Fbp1 is important for fungal sexual reproduction and the mutant showed attenuated virulence in mouse models (Liu et al., 2011).
References
Liu et al., 2011: Liu TB, Wang Y, Stukes S, Chen Q, Casadevall A, Xue C. The F-Box protein Fbp1 regulates sexual reproduction and virulence in Cryptococcus neoformans. Eukaryotic cell. 2011; 10(6); 791-802. [PubMed: 21478432].