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ERG11

Victor ID 5302
Gene Name ERG11
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886550
NCBI Protein GI 799322300
Locus Tag CNAG_03009
Genbank Accession CP003822
Protein Accession XP_012048275
Taxonomy ID 235443
Chromosome No 3
Gene Starting Position 222005
Gene Ending Position 222822
Gene Strand (Orientation) -
Protein pI 9.28
Protein Weight 14097.32
Protein Length 134
DNA Sequence 
>gi|799350639:222005-222822 Cryptococcus neoformans var. grubii H99 chromosome 3, complete sequence
TGGGATATGTTTTTACTTTGTGGCGAGAAATGCATGTACCCAATTGAAAAATCTGACGCTGATCTCTGGT
TGGCTAAATGATCCGAATCTAAGCAGTGTAGTGCTCTCGTTGAGTGAGCATCCAGATGAGACCAGTCCCT
GCAAAGCGAAGTTGTCAGTCATGTCCTATGCTATCCAAACATCCAACCAACATCCAACAATGAGAGGTCC
GATAGAAGCTCGATTAGGCTTTACAGACTTGAACACGAGCAGTTCTGTCGTAAAATGGAAAGTCGCAAGA
GCATAAGTGCCAATACCAAGGTTGTACACACTACTCGCAAAAGCATCAGTTCTGTAATACATATACAAGT
GACAGACGTAAATAGCTTACAGAGGATCGTTAATGTTATAAGATGCCATTCCTCGAATCAAGCTGGCGAG
TAAAGTCCAAGCACCAAAGATTCGTCCAGCAAGGAAAGTCACTTTGATCGCAGATACCCAGCAAAGGTAT
TCCTCATCAGTCTCGCGGTTCGTCTTACCCAACCATCTAGCTCCTAACTAAAGCGAACCCACTCTCTTCA
GCCTTCCCGGCATAGACTTCTTTGCTCTGCCAGATGACAAAGTAGTTTTGAACGGCGTTATAAGTGCCGG
CCACGGAGGTCAGGAGTAGCCAGTAAGGGAGGATACCGGCTGTTGCAGATGGGAGGACTGTACATATAGA
TATGTCAATAATTGCACTCTTTAGTTGTGGTCACGATGAGCAAGTGCCATACGCACAGGATGACATGGTT
ATTTTGAGTATCTGTGAACGAAGTTGGAATAAAAAACACGCAGTTGAA
Protein Sequence 
>gi|799322300|ref|XP_012048275.1| hypothetical protein CNAG_03009 [Cryptococcus neoformans var. grubii H99]
MSSFLPSATAGILPYWLLLTSVAGTYNAVQNYFVIWQSKEVYAGKAEEMTFLAGRIFGAWTLLASLIRGM
ASYNINDPLVYNLGIGTYALATFHFTTELLVFKSVKPNRASIGPLIVGWTGLIWMLTQREHYTA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ERG11 is the target of FLC and AFR1, the major transporter of azoles in C. neoformans (Revankar et al., 2004; Sionov et al., 2010).
References
Revankar et al., 2004: Revankar SG, Fu J, Rinaldi MG, Kelly SL, Kelly DE, Lamb DC, Keller SM, Wickes BL. Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans. Biochemical and biophysical research communications. 2004; 324(2); 719-728. [PubMed: 15474487].
Sionov et al., 2010: Sionov E, Lee H, Chang YC, Kwon-Chung KJ. Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes. PLoS pathogens. 2010; 6(4); e1000848. [PubMed: 20368972].