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ECA1

Victor ID 5301
Gene Name ECA1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886879
NCBI Protein GI 799336286
Locus Tag CNAG_03370
Genbank Accession CP003827
Protein Accession XP_012051213
Taxonomy ID 235443
Chromosome No 8
Gene Starting Position 776576
Gene Ending Position 781617
Gene Strand (Orientation) -
Protein pI 4.68
Protein Weight 21658
Protein Length 190
DNA Sequence 
>gi|799350780:776576-781617 Cryptococcus neoformans var. grubii H99 chromosome 8, complete sequence
CCTCGCAGACGTGCCGTCCGTCAACCTCTTCCCTGCCCAGATCTCACAAGCGGGCCAAATCTACACGCCA
AAGTCTCGGCGGCAGACCAAAGCGAGAAGCTTCGATACCAATGGCATGTTTATTTTTACTGGGGAGGCGC
GCTGAGCATGTCCCGCTGACTACTTTTGCAACATACAGCTTTCACAACAATTATCTACATTCTCCCTTCG
CCAAGACGTATTGTCTGAAATGCTGGCTCAAGAAACGCCTCCAACCATCACTTCGCCATTCAAGTATGCC
TCCCACACCACTTCTGCCTCTCTAACTACACCATACACATCGACGTTCAAGCACCACCCATCCGCTGAGC
ATATGCCGGCAAAGTCCAAGTCGGCTGGGCCCAAGTTTGTGACCCAGAACTCAAAGGGCCGTCATATCGA
AGACATATCTCCTACTCGCCCAGCGTCCGAAGACCATCTGGCTGACTGGGACGTATCCCATCCAAGCTCT
GACGAGCCCGACTTAGAGTGGTTGCAAAGCGGGGAATGGCTGCCCCCGCTTCAGTCAAAGGAGAGTAACG
CGCAAGATTGCCTTCAGGGATCCTTACAACACTGTAGAGACAGAGATTGTTCCGTGTCTTCTATGGAGTT
CAGCGGAAGCGACACTAGTTCGGTTTCCCTTTTGTCTCTGGCTAGAAGCTCTCTGGAGCAACAAACTAGA
CCGGATATCGTGCAATGGGATGAAAATCCAGCAGAAATAGATGGAGAACAAGCAGGACATTCGGGCTTCG
ATGCACGGTCAGGATCAAGTGCATTGCATTTGCCCATCAAGCTCAACTCCTCACCATCCATATCACCTTT
CATCACCAGCGACTGCCACAAACCTCCCAACGATACTCCCCCTGGTCCCTTTGATAACCAAGCCGATTTC
CCCATGGACTCCCCATCTGTATTCAGTACTCGCTCTTCCCAGCACGCTCGCTCGGACTCTCGCTCTACAA
TATTGCCCCGATTGCTGTTATCGAAGAAGAGCACAGCGACGCTCAGAGAACAAAATGAAAGATCCAAAGT
TCTCGGCCATATGGAAGACGAGGAAATGATGTCGGATGTTGAGGATATCCCTTCACCAAAGAGTCCTTCC
CGTCCCAAGAGCTTTTGGGATCGAGCGAAGTTTAAGACATCGCGTAACCGTTTTGACGGCAATGGCTTCG
GGGCAACATTTGGGCTTGGCATAGAGCTAGGACCTCGCCGTATACCGTCGGTCGAAGATCACAATGAGAA
CAATGGGCTTTCGGTGTCGTTAGCTAGCGATTCAAGCGGTGACGCAGATCTATCACCTTCCCGATCACTA
TTGGCCAACAGACGTTCCTCGAGCACCTTTGCGCACGATCCTGCAAATGACAATGCTCCCGAGGTCGGTC
CTCGTTTTGAAGCACCTACACGACCAACAATGCCACGTCGCATACCGACAGTCGGCTCTATACTTCAACG
AATACCACGAACAAGCTCCCCAGCTATCCCTACCTTGAATAGCCTTCGTGGTAAAGGACGGCCACCAATG
CGAAGAGGCACAACAGAGCCCACTGAAAAGCCCAAACCCACCCTACTAATGGCTGACGCGGCTTTAAGCA
CTCCCCACGCTTTGCCATTTGCCGATGTTAAACCTTCCCCCAGTGTCTTCGCCTCTGCGGGTCTGGTGAA
AAAGAAGTCACGCTTTTCCGGTGCGGAAATCCCAAAGTTTGGCAGTGAGCCGCTGGCGAATGTCAAGAGG
ACGCAATCTGCCGCGCAATATGGCATGCAGCCTGCTCCTGGCCCTGGATCAATGCAGCCCCCTAGCCCTG
TATCGCCCATCCAATCCATGTCCGCTCCGTCGATACCATTGAAAGGCACTGGTTTTATGACAGCAGGATC
AAGCAATGCCCATTTTGCCCAACAAGCCCAAAAGACAAGAGGCTTAAGGAAGAAGAGGAGTTCGATGTTC
AAAGCTGGAAGCTCCATCAGTAGTATGGAAATGATTAGAGGGAACAGTCGCGGTTCGATTAGTGGAGTAT
CGTTGTCTCCCGTAACTCCGACGAAACATGACGGTAAGTTCATCTATTGATGCTGGCATCACAGCTGACG
AGGTGTGTAGGTGCCCCCAAGGTCTACGGGCTGACGACCCCATCACCAATACGAGCGCCTGTCGTCTACC
CCTTCGCTTCCTCTAACCCTGTCGACCTCGACCTCTTCTCTACTCCCCCGTCTAATCGGCTTAATCGACC
GGGCGCTCTTGATGCCCCCATTGCTGAGCGATATCGATCAATGCTTGCTGGAAGTCCTAATGCCACAATG
GAAGCTCAACGTAAACCAGTAATCCGAGCTTCCAATCCCATGTTGGCCGCTAGTTTTAAGAGTGCTGCTC
AAATAACTACGCCAGCTAGAGGCCACACGTCTCAGGGCCTATCTATGTTTGTTGGTAGGCCGAAACTAGG
TGGTGAGGGCATCACAAGGCTCGAAACAGATTTCGCGCTCGTGGAGAATCTTGGTAATGGAGCATTTTCC
CAGGTATGGAAGGTTCGTGAGAAGAAAACCGGCAAAGTCTTCGCCGTCAAAGCAGGTAAACCTTACACCG
GTGCCAAGAATCGTCTTCGACAGCTTGAAGAGATTGCCATCTTACGTGAGCTTTCTCTCGACCCGCACCC
AAATGTTATCCAATACATCGATTCTTGGGAATCTCACTCTCGCCTGTATATCCTCACAATCCTGGTTGAT
TGCGGTGACCTTTCCACCTTCCTTTCTCTTCTAAGCGACCACGGCGGCATCCGCGAGGCTCGTGTGTGGA
AATCCTTGGTAGAACTCGCTGAAGGTATCGACCACATCCATAAACACCACTTCCTCCACCTTGACGTCAA
ACCATCCAACATTTTGATTAACAGCGCTGGTGGACTAGTCGTTGCCGATTTGGGTATGGCCGTCATTTGC
GGCGACGGTCCTGACGGTCATATGCTCGGGGGTATGAGCCCTGCGTTACCTGAAAGGGACGAGAAAGGAG
GGTTCGTGTGGGATCAAGTAGAGACGCCTATGGATGATGGAAAGAAGAGTTTGGCCATGGTGCCAAGTCC
TATCATGGATCGAGAGGTCGAAGGGGACAGGGAGTATCTGTGCCCTGAAGCCTTGAGTGAGGCTGAGATG
ATAGGGAAGGGCGCAGATGTGTTCAGCTTGGGTATTTTGTTGTTGGAATCGGCGCTCAATGTTGTGCTAC
CCAGCAGTAAGTGATGATTGTTGTTGGATGTCTCGTGACATGTTGCTAAGTATCTTTTTTTTTTAGATGG
GGACGCTTGGGTACAACTTCGCAATGATGATTTCTCTGATCTTAATGGGATTTACATTCCCCGCCCACAT
TCCGCATCATCCCCTAATCTTAATCCTCCCTCCGACGATCCCAACATGCCAGTCCTGTCGGATGACATAT
TGACTGTCATCAAGGGTATGATGCGATCCAATCCCGACCGACGATGGAGTCTAGGTGATGTCTGGAGGCA
TCCAGTTGTCAAAAGGGTGAGAGCTTCCGAACGGGGAAAAGCTTTGGTAGAGGAAAGCGACGAATGGTTG
AAAAAGGTACTTGGAGAAGAATTGTAAAATAATAAAAGCAGAAGAAGCAAAGGCGTCGGAAAAATATAGC
GTAGATCAAAAGAGAAATCATTGTTTTCAAAGTAGACTGTATCATAATTTGCATGCCATCGACGATGGCC
TTATCTTATAAATAAGTCGAATGCACCTTTTTTTTTGCTCAACTTCAGCTCAAGAAGAAGCTGCAATCGT
AAACATACATATGGATAATAAACAAGTGTATGCAGGTCATGCAAGAACCGATCCGATCTATCTCATATCG
TAAAATTCAAGATTTAAAACGAACTTGTGCTCTCTGCAGTCTCTTCTACACCAACCCATCATACAGTGAC
AGAGCCTATTTAAATGTAGATCAGTTGCCGTTTCTTCAACGTCTATGATATCCAGCAGCGCACCTGTACG
ATGGTCGGATCCTGCTTGGAGCCCTCCTTGAACTCGTCATATGTCAGTCGATGGTCCTTATTCAGATCCA
TGTTCCTAAAGATCTTGTCGACTCGCTTGAACACAAAACATATCAGTATTGTAACGACGGTTTTTGCAAG
TGTTTCAAATTCTGACCTTTTCGGGAGTATCTTCATCCTCTGGCAACTGGACCATTTGTCCTGTCATTTT
ATAAATAGATCGTACAATCTGAAGCATCTCATCGTAGGTGATGTAACCGTCTTGGTTAATATCATACAGT
TGGAACGCCCATTTAAGCTTTTCGTCAAGACGACCCCGAGAGGTAACCGAAAGGGCGCAGATGAACTCCT
GCAAAGGGTATATGAGCTGTTTGTCATGCCCAACATATTTCTTCCGGCACAAACGCACCTTGAATTCTAT
TGTCCCAGACTTATCTTCGTCAAACACCTACACGTAAATAACTGTCAGTTTGCCAATGGTGACGCGTTCT
GCTTACTCACGTTGAAGACATAATCTGCAAACTGACTAGGATCACCGAAAGGAAAGAATTGTCGATAGAT
TTTCTTAAACTCTGTGCATACTTTTAGCCAGACGCAAAAATGAAATAAAAGTTGATACCCACCTTCCTTG
TTCAGTTGACCACTAGGACAGTCCTTGAGGAAGCCTTTGTACTGTTCCCGGGGATAGTCAGCCCTCCGGA
CTCGCATCCCTTAATTCACTCACCCATTGTTGGAGTTCCTATAATGTGCGGAATCGTACAGGTCATTCTC
GTCAGGAAACTGTACGCCAGTCGCAACATGCAAATATGTCTCACCTTCTTATCGACTACGCGCGTACGTG
GTCAGCACTGTTCACCTGCTCCGATGGCCGCGGAGTGTACTCACAGTAAGTGTTTTTTTGGAGCTCGGCA
AGCTCTTCAGAGGATAATTTGGATTGCGACTTTCCCATTAGAAACCTGTTTGATGTTCCGGGAGCGGCAG
GACGTTACTTGTCTGCGTGTGAGGAAGGGTGCTTGGTATGTGGATATGCGGATGTAATTAGTTGGAGGGG
AT
Protein Sequence 
>gi|799336286|ref|XP_012051213.1| calcium-binding protein NCS-1 [Cryptococcus neoformans var. grubii H99]
MGKSQSKLSSEELAELQKNTYFDKKELQQWYKGFLKDCPSGQLNKEEFKKIYRQFFPFGDPSQFADYVFN
VFDEDKSGTIEFKEFICALSVTSRGRLDEKLKWAFQLYDINQDGYITYDEMLQIVRSIYKMTGQMVQLPE
DEDTPEKRVDKIFRNMDLNKDHRLTYDEFKEGSKQDPTIVQALSLYDGLV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Eca1 is involved in maintaining ER function, thus contributing to stress tolerance and virulence acting in parallel with Ca2+-calcineurin signaling (Fan et al., 2007).
References
Fan et al., 2007: Fan W, Idnurm A, Breger J, Mylonakis E, Heitman J. Eca1, a sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, is involved in stress tolerance and virulence in Cryptococcus neoformans. Infection and immunity. 2007; 75(7); 3394-3405. [PubMed: 17502401].