Victors

CTS1
Victor ID	5300
Gene Name	CTS1
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23886831
NCBI Protein GI	799335143
Locus Tag	CNAG_03319
Genbank Accession	CP003827
Protein Accession	XP_012050913
Taxonomy ID	235443
Chromosome No	8
Gene Starting Position	637911
Gene Ending Position	641643
Gene Strand (Orientation)	-
Protein pI	6.42
Protein Weight	106978.48
Protein Length	1087
DNA Sequence	>gi\|799350780:637911-641643 Cryptococcus neoformans var. grubii H99 chromosome 8, complete sequence CCGAAACTGTAAAATCCAAAACGCCCTTATCTAATCTCTTATTATACCATTCCACCATCTTTTTTTACGA GGCAAGCCCATTTTGTTCACATCCTTTTTGAAAATCAACTGTATAATTTTTATAATAAGCAAGATGAAAG TAACTATTATATGCAGACCCTTTTTTTTTTTTGTTCTTTGTTTTTGTCCCCCTTCACCTTCCCCCTCCGG CCCCTATCACCGATTCTTATCCAGATATTCAAAACTCCCCCTTTATGACTGCACACCCGCCTGTCCACTT TCATACCAATCCTGCACGCTCTTCAACAATCTCACCACCCCATTCTTATCCCCCACCCTGACTTCATTAA TACTAATCCCGTCAATCTTGACACCCGCATCGACAAGCATATCCATCATCGCTATCAACCCACCCAACCC CGGCTGTCCATCGGCTTCGCGCTCGAAAGCTGCAGGAGAGACGGGGGGGCTAGGCTCGACGCCAGAAAGA GATTTGACGAGGGAAAAGATGATTTCGCCAGAGACGAAGGATTCAGGGAGGGAAAGAGTCGTGCGCGGGT AGGTCGCTGGGAGATGGGTGTTGACCCATTCAAGAAGCTGGGGGGCTTCTGATGTGGAGACGTTGCTGGG AGCGCCGGGAGCGCCACCGCTGCTGGTTTGGCTAGTCACAGGAGCGGCAGCCGCACCAAGAGGAGCAACA CCATCAGCGCCAGCACCAGCACCAACACCAGCACCAGCATTAGACGCGGGTTTTTGTGTGTTCTGGCTAA AGTTGCTAGAAGGGCGTCTCATATCCCTACTCGGTCGAGCTGGGGACGCACCCACACCAAGGTTCTGGCT CGCACGACGTTTTTCCCCAGAAGTCGTATCCAAACTCATCTAACAATGGTCAGTTTTTACAAAGGATTGC ACAAAAGAAAACATACCAAGATATTAGCGTCGTGCGGAGTCAACTGGTTTGGATTCTCTCTCCTGGTAGC GCGCTGCATAGCCGCTCTGGTCGCGGGACTAGGCGGTCTCGGCGCAAGCGCCTGGGCCTCTGCAAGCGGT ATCGTCGGGATATTACACGAGCTCGTGATCGGTTTGGTGTAATCCCTCGCGATCGTAGCCTTTAACAATG CCTTCATCCACCCCCGCACTACCGTTTGCTCGCTCGACGAAAAGGAGTGGCTCTTTGCACCACCACCAGC ACCACCAGCAGCACCAGCGGCACCACCAGCCCCGGTACTCGCGGCGAGACGGAAACCGTACGAACCAGGG TTTGCATTTTCGTCCGCCATGATTCGGTGGGTGTGGAGGAGGTCGATCCGGTCTTTAAGACTGTCGGCAT GTTCGGATTTGAGAATGTAGAGCGTTGAACCTTTGAGGACGACGTAGCGGGATTTCCACCCGCCGTACCG CTCTCCCTTCTTTTTGAGGTAGCCGGCGTGATCGGGCGTACCGATCTGTTTCAAGGCTGCGCCGCCTGTC GATACAGCGATAGGGGTAGGGCCCGAGACGCGCTTGTTCTGCGGACTGGCAGGCTGCATCTGATGTACTT TACTACTCCCAAACCCAAGCCTTGAAGACGACGATCTCATTCCCTGCTGGTGCTCCCCTGTAGTGGGCGA GCCAGCACCGGCAGCACCGGCACCGGCCAGGGGTGCAGGGGGTTTCCGGTTCCTTCCGAAAAAGCTCAGT CGATCTTTGGAATCTACACTAGGTTTCCCGCGCTTGTGGCCGAGAGACCCGAGGGAATCGCGTTTGGTGA CGGTAGAGCCGGCGGCGGTGACGGGACTGACGGGTGTGCTTGCCGCGGTGGTGGTGCTTGTAGCGCGGAC TGAGCTGGATGCAGTGTTGGACGAAGGAGGGGGTTGGGAGGAGCGATTAGAAGTGGTCTTGTTCACTGCT GGCTGGGCTTGGGTTTGGGGCTGGGGCTGGGAGCCACTCTCGTTGATAGATTCCATGATAAGAGGCGCAG TGTGCGCGCTTCCGCTGTGTTTCCTCGGATGATGAGCCCATGCGCCGTATGCACCCTGTTCCTCTGAATG ACTCGGCATAGGGGGAGTAGACAGGGGAGGAGTAGATGGGAAAGGTTGACTTGCACCGACACCGACACTG TATGAAGATGGGGGAGCGCTCATGCCGCGCAATGAAACGCCAGGCGACATGTGGGTAGGCAAGCCAGAAG GGGAGAATTGCTGGGAGGACGAAGAGACCATGGAGGACGGACGTCGAAGCTCGGCGATGGCGGCTGCGAT TCGCATACGTTTGCCAAAGGCGGGGATGTCGAGCTCTTTGAGGAGGTTGGCGTCGAGTTCAAGTAGGACA TCACCAGAGATCTCGTGTTCTGTCGTAAAAAATCGTTAGCACAAATGGATTTTTTTTTTTTTTAAAGATT TAGATACTTGCCCCTGAATTTGTCACAGATACTGTCGTCAAAGCCCTTTGCCTGGGCCCAAGACACCACA TCGTCCACAGTCCAGCTGGTCGGTGGCTTGGCCGGGATGCTGGACGAACGGTTGGACGTTGAACTCGGTG GTGCGGCGGCGTTTTGGGCAAGAGGAGTCGGGGTGATGGCACCTAGAGTAGTAGGCGTCTGGACAAGTGG AGGGGTGGCGGGGATGAATGCTGGTTGGAGAGTGCCGACAGATGGCTCGCGTTGGTCAGAAGAGGTGGGT ACGAGAGGAGTCAATTCGGGTTCGGGTTTGGGCGTTGCGGCTGGGCCAGGGACAGTAGCGGCCGCAGTGG AAGTGGCCACAATAGGTGCGGGGATCAGAGCAGGTTCGATGGTTTTCGGCTCGGCGGGAAGCGTTTCAAC AGGCTCATCATGAAAACCGTTCACGTCCTGCGACTCTGTCCCGATACTTACGATACTTGTCCTGGACTTG GTGACCAGAGGCAAGCCCTTTCCAAAGTCTTCTTCCTCATCTTCGCTCTCGTCCGAGTAGACAAACCCAG TCTCGTCCCTTTCCCGCTTCTCATTGGCGAGTCTCGCCTGCTCGACGAGCTTTGCTCTCGCATCCTGGCC GATACCCAACTCTGCGTGCTCGTGCTCGTCATCGCTCTCGGGTCGAGCATAGGACTCGATGGCATCCTGG ATGTCACCTATAGTGCGGTTCATGACGTTGCCGACATTCGCAGCGGCGGCACCGGCAGACGCTGTCGCCG ACTCGAGGATGCCGCCTTGCGCATCGGTCGTGCCCTTGGGCGACTCGTTGGGGATGGGGATGTCGGGGAC GGCGAGGCTGTTGTCGGCGGGCCAAGCGCCGGGGGCGGGATCGTCGGCTTGGGGGAGAGGCGGCGTTGGG GTTGGAGCGGGGATGGCCGCGGGAGGTGTCTGGGTGTGGATGGAGGGCTGCTTGGTGGACGGCTGCTTGC CGTTGACGGGATTTTCCGCGGGCGCCGGCGGGGTCTCTGTCTTCGCTGGGGTGGCGGGCGAGGCGGGCGA GGCGGGCTCGGGAGACTCGGAGATGTAGGTTGCCGGGAAGAGGCCTTCTTCGCCCTTTGGATTCCGTCCC TAGAGGAGGATGGTGAGCGGGGCGGGGGACGCAGGGGGGTACTCACTCTCCACCAGCCGTCGCCAAAGGC CTCGTCTTTCTCAAGGACGACGATGTGGTCGCCGGCGTGGAAGTCGAGCTCGTCGCCGTGCTCTGCGACA AAGGTGTGTATGGCGCGGACTGTGAGCGCCATGCTGGGTGGGGGGGAGGGGGAGTGAAAGAGGGAGGGGG AGTGGAAGAAGCAAGGAACGTTT
Protein Sequence	>gi\|799335143\|ref\|XP_012050913.1\| phospholipid binding protein [Cryptococcus neoformans var. grubii H99] MALTVRAIHTFVAEHGDELDFHAGDHIVVLEKDEAFGDGWWRGRNPKGEEGLFPATYISESPEPASPASP ATPAKTETPPAPAENPVNGKQPSTKQPSIHTQTPPAAIPAPTPTPPLPQADDPAPGAWPADNSLAVPDIP IPNESPKGTTDAQGGILESATASAGAAAANVGNVMNRTIGDIQDAIESYARPESDDEHEHAELGIGQDAR AKLVEQARLANEKRERDETGFVYSDESEDEEEDFGKGLPLVTKSRTSIVSIGTESQDVNGFHDEPVETLP AEPKTIEPALIPAPIVATSTAAATVPGPAATPKPEPELTPLVPTSSDQREPSVGTLQPAFIPATPPLVQT PTTLGAITPTPLAQNAAAPPSSTSNRSSSIPAKPPTSWTVDDVVSWAQAKGFDDSICDKFREHEISGDVL LELDANLLKELDIPAFGKRMRIAAAIAELRRPSSMVSSSSQQFSPSGLPTHMSPGVSLRGMSAPPSSYSV GVGASQPFPSTPPLSTPPMPSHSEEQGAYGAWAHHPRKHSGSAHTAPLIMESINESGSQPQPQTQAQPAV NKTTSNRSSQPPPSSNTASSSVRATSTTTAASTPVSPVTAAGSTVTKRDSLGSLGHKRGKPSVDSKDRLS FFGRNRKPPAPLAGAGAAGAGSPTTGEHQQGMRSSSSRLGFGSSKVHQMQPASPQNKRVSGPTPIAVSTG GAALKQIGTPDHAGYLKKKGERYGGWKSRYVVLKGSTLYILKSEHADSLKDRIDLLHTHRIMADENANPG SYGFRLAASTGAGGAAGAAGGAGGGAKSHSFSSSEQTVVRGWMKALLKATIARDYTKPITSSCNIPTIPL AEAQALAPRPPSPATRAAMQRATRRENPNQLTPHDANILMSLDTTSGEKRRASQNLGVGASPARPSRDMR RPSSNFSQNTQKPASNAGAGVGAGAGADGVAPLGAAAAPVTSQTSSGGAPGAPSNVSTSEAPQLLEWVNT HLPATYPRTTLSLPESFVSGEIIFSLVKSLSGVEPSPPVSPAAFEREADGQPGLGGLIAMMDMLVDAGVK IDGISINEVRVGDKNGVVRLLKSVQDWYESGQAGVQS
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: The cts1 mutant exhibited defects in cell separation, growth, mating, and haploid fruiting however these were inviable when calcineurin was mutated or inhibited (Fox et al., 2003).
References	*Fox et al., 2003:* Fox DS, Cox GM, Heitman J. Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans. Eukaryotic cell. 2003; 2(5); 1025-1035. [PubMed: 14555485].


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CTS1