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ipaH9.8 from Shigella flexneri 5a

Victor ID 53
Gene Name ipaH9.8 from Shigella flexneri 5a
Sequence Strain (Species/Organism) Shigella flexneri 5a
NCBI Gene ID 876625
NCBI Protein GI 13449172
Locus Tag pWR501_p233
Protein Accession NP_085388.1
Taxonomy ID 623
Plasmid No pWR501
Gene Starting Position 172000
Gene Ending Position 173667
Gene Strand (Orientation) +
Protein Name invasion plasmid antigen
DNA Sequence 
>gi|13448939:172000-173667 Shigella flexneri 5a virulence plasmid pWR501, complete sequence
TTTGTCCACCGGCTTTAACTGGATGCCCATCATGTTACCGATAAATAATAACTTTTCATTGCCCCAAAAT
TCTTTTTATAACACTATTTCCGGTACATATGCTGATTACTTTTCAGCATGGGATAAATGGGAAAAACAAG
CGCTCCCCGGTGAAGAGCGTGATGAGGCTGTCTCCCGACTTAAAGAATGTCTTATCAATAATTCCGATGA
ACTTCGACTGGACCGTTTAAATCTGTCCTCGCTACCTGACAACTTACCAGCTCAGATAACGCTGCTCAAT
GTATCATATAATCAATTAACTAACCTACCTGAACTGCCTGTTACGCTAAAAAAATTATATTCCGCCAGCA
ATAAATTATCAGAATTGCCCGTGCTACCTCCTGCGCTGGAGTCACTTCAGGTACAACACAATGAGCTGGA
AAACCTGCCAGCTTTACCCGATTCGTTATTGACTATGAATATCAGCTATAACGAAATAGTCTCCTTACCA
TCGCTCCCACAGGCTCTTAAAAATCTCAGAGCGACCCGTAATTTCCTCACTGAGCTACCAGCATTTTCTG
AGGGAAATAATCCCGTTGTCAGAGAGTATTTTTTTGATAGAAATCAGATAAGTCATATCCCGGAAAGCAT
TCTTAATCTGAGGAATGAATGTTCAATACATATTAGTGATAACCCATTATCATCCCATGCTCTGCAAGCC
CTGCAAAGATTAACCTCTTCGCCGGACTACCACGGCCCACGGATTTACTTCTCCATGAGTGACGGACAAC
AGAATACACTCCATCGCCCCCTGGCTGATGCCGTGACAGCATGGTTCCCGGAAAACAAACAATCTGATGT
ATCACAGATATGGCATGCTTTTGAACATGAAGAGCATGCCAACACCTTTTCCGCGTTCCTTGACCGCCTT
TCCGATACCGTCTCTGCACGCAATACCTCCGGATTCCGTGAACAGGTCGCTGCATGGCTGGAAAAACTCA
GTGCCTCTGCGGAGCTTCGACAGCAGTCTTTCGCTGTTGCTGCTGATGCCACTGAGAGCTGTGAGGACCG
TGTCGCGCTCACATGGAACAATCTCCGGAAAACCCTCCTGGTCCATCAGGCATCAGAAGGCCTTTTCGAT
AATGATACCGGCGCTCTGCTCTCCCTGGGCAGGGAAATGTTCCGCCTCGAAATTCTGGAGGATATTGCCC
GGGATAAAGTCAGAACTCTCCATTTTGTGGATGAGATAGAAGTCTACCTGGCCTTCCAGACCATGCTCGC
AGAGAAACTTCAGCTCTCCACTGCCGTGAAGGAAATGCGTTTCTATGGCGTGTCGGGAGTGACAGCAAAT
GACCTCCGCACTGCCGAAGCCATGGTCAGAAGCCGTGAAGAGAATGAATTTACGGACTGGTTCTCCCTCT
GGGGACCATGGCATGCTGTACTGAAGCGTACGGAAGCTGACCGCTGGGCGCAGGCAGAAGAGCAGAAATA
TGAGATGCTGGAGAATGAGTACCCTCAGAGGGTGGCTGACCGGCTGAAAGCATCAGGTCTGAGCGGTGAT
GCGGATGCGGAGAGGGAAGCCGGTGCACAGGTGATGCGTGAGACTGAACAGCAGATTTACCGTCAGCTGA
CTGACGAGGTACTGGCCCTGCGATTGTCTGAAAACGGCTCACAACTGCACCATTCATA
Protein Sequence 
>gi|13449172|ref|NP_085388.1| invasion plasmid antigen [Shigella flexneri 5a str. M90T] MSTGFNWMPIMLPINNNFSLPQNSFYNTISGTYADYFSAWDKWEKQALPGEERDEAVSRLKECLINNSDELRLDRLNLSSLPDNLPAQITLLNVSYNQLTNLPELPVTLKKLYSASNKLSELPVLPPALESLQVQHNELENLPALPDSLLTMNISYNEIVSLPSLPQALKNLRATRNFLTELPAFSEGNNPVVREYFFDRNQISHIPESILNLRNECSIHISDNPLSSHALQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaH9.8 deletion mutant caused more severe inflammatory responses with increased pro-inflammatory cytokine production levels than did wild-type Shigella, which resulted in a 30-fold decrease in bacterial colonization in murine lungs (Okuda et al., 2005).
References
Okuda et al., 2005: Okuda J, Toyotome T, Kataoka N, Ohno M, Abe H, Shimura Y, Seyedarabi A, Pickersgill R, Sasakawa C. Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses. Biochemical and biophysical research communications. 2005; 333(2); 531-539. [PubMed: 15950937].