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CTR2

Victor ID 5299
Gene Name CTR2
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23885542
NCBI Protein GI 799343669
Locus Tag CNAG_01872
Genbank Accession CP003830
Protein Accession XP_012052816
Taxonomy ID 235443
Chromosome No 11
Gene Starting Position 1144864
Gene Ending Position 1146030
Gene Strand (Orientation) +
Protein pI 7.23
Protein Weight 19750.25
Protein Length 192
DNA Sequence 
>gi|799350881:1144864-1146030 Cryptococcus neoformans var. grubii H99 chromosome 11, complete sequence
ATGTATACAGTATCTACACGCAAGGTAACACACTCTATTTGAACAAAGAGCCCTTATTCCCCTGTCATAT
CTACCCTTACAACAACATGAACCACGGTGATCACTCGAAACATACTATGCCTGACATGGACATGCCCGCT
TGCTCGGTAGGTTGTCCTTGTCTCTACTCGCAGAGTACGCTGTGTCAGGCTAATCAACATGATGCTAGAT
GAACATGCTGTGGAATAACCAAGTAGCAGACACATGTGTTGTCTTCCGCTCATGGCATATCTCGGGTACT
TGGACTATGATTCTTTCTTGGTGAGTCTATATAGCAGCAACTGGGGGAAATAATGTGCTGACTGTACAGA
ACCATCGTAGCCTTATCATCATTGGCATCTCCGTTTTTTATTCTTACCTTCTTCATTACATCAAAGATTA
CGATCGTCATGTCGCTGCTGCCATTTATTCCTCTACGCAGCAAGGTCGGAGGGACAGAGACGGCAGCCCT
GCTGAAACAGGTCTCATACCACCTATCCCAACTGCGTACGGCGGGATCGAAGTAGGTGCTTTGAACAGGA
TTGGAGTGTAAGCATTCGCCCTTGTGCTGCTTCATCAGAAAGGAGCTCATTATCGTTCGGCCTGGTAGTA
CCAGGTTGCCGCTCAGATTGAGACTGATTAGGGCTGGACTCTATGCCGTTACCGTAGCCATTTCCTTCTG
GGTAAGTATCATTACCAAAATGGGCATTGCTCTTCTAGGAAATGGATGAAACTGACATTTTTTTCTTTCC
TTTATGCCTCAGCTCATGCTCGTCGCGATGACTTACAACACGTATCTCTTCAGCTCCATTGTCGTTGGTG
CTTTCTTCGGTCATGTGATATATGAAGATGAGATGGACGTCGGGTAAGCATTTATCTATGCAAGAATAGC
GGATAAAATGTGCTAGCCACTGATAATCGTTTGCAGGGCCGTGTTGTCTGGTACGAGTGGGAAAGGGTTG
GCTTGCCACTAAGGGGCTACTGGTGTAGAACATGATGTACATTTTATCTGGCATTCAGAATCAATCAGAC
GGCCCCGCTATGTTTTCGAGCATCTACACGCTAAGTGATGATAGGAAAGGCCCCGCAGCAGATGCCAATA
TGTAATGGATGGCCGAGCTCTTTTGAAATATCATCCTTTCAAGTTCT
Protein Sequence 
>gi|799343669|ref|XP_012052816.1| solute carrier family 31 (copper transporter), member 1 [Cryptococcus neoformans var. grubii H99]
MNHGDHSKHTMPDMDMPACSMNMLWNNQVADTCVVFRSWHISGTWTMILSCLIIIGISVFYSYLLHYIKD
YDRHVAAAIYSSTQQGRRDRDGSPAETGLIPPIPTAYGGIEVGALNRIGVTRLPLRLRLIRAGLYAVTVA
ISFWLMLVAMTYNTYLFSSIVVGAFFGHVIYEDEMDVGAVLSGTSGKGLACH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The mutant displayed sensitivity to copper starvation and defects in polysaccharide capsule production and melanization, leading to increased phagocytosis by murine RAW264.7 macrophages (Chun and Madhani, 2010).
References
Chun and Madhani, 2010: Chun CD, Madhani HD. Ctr2 links copper homeostasis to polysaccharide capsule formation and phagocytosis inhibition in the human fungal pathogen Cryptococcus neoformans. PloS one. 2010; 5(9); . [PubMed: 20824073 ].