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CRZ1/SP1

Victor ID 5297
Gene Name CRZ1/SP1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23884579
NCBI Protein GI 799315987
Locus Tag CNAG_00802
Genbank Accession CP003820
Protein Accession XP_012046971
Taxonomy ID 235443
Chromosome No 1
Gene Starting Position 2122202
Gene Ending Position 2123278
Gene Strand (Orientation) +
Protein pI 4.51
Protein Weight 26002.37
Protein Length 249
DNA Sequence 
>gi|799350543:2122202-2123278 Cryptococcus neoformans var. grubii H99 chromosome 1, complete sequence
TCTTCTACAAATTCTCTCCATATCCCCAGCAACATCTCTTCAACTGTCTACATCAAGAAGGTCCTGGAAA
AATGACCATAAGCTCACCGCAAAGACCCAACGGCCAACCTATTGAGCACGAGCCCACCAACACACTCGCC
CTCCTTCTTCCTCACCCTACCCTGTTTGCACCTCCAGTCCTCGATCTGTTGCGCGCACACTATGAACATT
TCGGGAGAATAGTTCACTGGGCTCCCGTAAGGGGATTCGGAAGGGCCATAGTAGTATTTGAGAGCGAAGA
AGAGGCTGAAAATGCGAAAAGACAAGGTGATTGGTTGAAATTGGACGTTCCTGTGGGTGGCGAGGAAAAG
GTCGATAATGAAGGAAAGTTAAAAGACATCGAGTATGTGGACCTATCTGAGAGTTCTGTGATGCAGTAAG
CTTACAGGGCATGAACAGGCTGGTCCTTCGATTACACTACCTTCCACCGACAACCCTCAACCCCGACCCA
GCCACCACGCACCTTGCACCCCCTCCTCTTCCACACAACTTTCTTATCTCCCCACCAGGTTCTCCGCCTG
AAGGCTGGGAACCCGCAGCGGAAGAAGCCCCTAACCGGATCATCCTTCCTGAGGATTTGCAACGTGCACT
GGAAACGCTGGAGTTAAATAGTGGGAGCAAGGCAGATGATGGGAAGGAGATCATCTTGGATGAAGGCGGG
GTGAGAGTGCAAGTGGAGGATACGACCAAGCAGGAGAGATACGGTGGGGAGGATTATGAAATGGGGGAGA
CATTGGAATCTGGGACTGGTGCTTGGAATCTTCCTAGTCAATCTGGCGGTATGGGTACACCTGCCTTTGG
TGTGAAGATTATGCCCACGACAAGGCCTCCTTTATGATCCACCATCGCCGGAGTCTTGGGAGAAGCTGAG
GGAAGAGTGCGGTGTAAGGACTTAAGGCATTATGAGCGAATGTCATGACCTCATGTCAGTCAGCATTGTA
TATGTACACTTTTTTGTAGACCCAATCCAATCATCTCGAAACAATAATACAAATTCATGCAATGATATAG
AACATCTCATGTATATCATAGAAATTA
Protein Sequence 
>gi|799315987|ref|XP_012046971.1| calcineurin-binding protein [Cryptococcus neoformans var. grubii H99]
MTISSPQRPNGQPIEHEPTNTLALLLPHPTLFAPPVLDLLRAHYEHFGRIVHWAPVRGFGRAIVVFESEE
EAENAKRQGDWLKLDVPVGGEEKVDNEGKLKDIELVLRLHYLPPTTLNPDPATTHLAPPPLPHNFLISPP
GSPPEGWEPAAEEAPNRIILPEDLQRALETLELNSGSKADDGKEIILDEGGVRVQVEDTTKQERYGGEDY
EMGETLESGTGAWNLPSQSGGMGTPAFGVKIMPTTRPPL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Crz1 is a calcineurin-dependent transcription factor. Ãˇâ€¯cna1, and a CRZ1/SP1 mutant (Ãˇâ€¯crz1) had attenuated cell wall integrity (Lev et al., 2012).
References
Lev et al., 2012: Lev S, Desmarini D, Chayakulkeeree M, Sorrell TC, Djordjevic JT. The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity. PloS one. 2012; 7(12); e51403. [PubMed: 23251520 ].