Victors

CRG1
Victor ID	5296
Gene Name	CRG1
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23883988
NCBI Protein GI	799312412
Locus Tag	CNAG_00125
Genbank Accession	CP003820
Protein Accession	XP_012046183
Taxonomy ID	235443
Chromosome No	1
Gene Starting Position	333923
Gene Ending Position	338058
Gene Strand (Orientation)	+
Protein pI	8.53
Protein Weight	68044.2
Protein Length	640
DNA Sequence	>gi\|799350543:333923-338058 Cryptococcus neoformans var. grubii H99 chromosome 1, complete sequence TCTTCGTTGTCCTTTGGTTTACACAACGTCAGTCCGCCTCACTACAAACCAGAGCAATGGAGCAACAACA AATGGGGATCGACACAGATAGAGTACAGGGGTCAAGAGATCGGTAATACTGCATAACTACGGCTATGCAG TTTTTCCTAGTCTCTTTTTCAGAAGCCACTTGCGTACAAAGCGGAAAAGATCAGAGTTGTCGTCACTGAG TGCTGCAGAGCTGCCATTACCTGACTACCACCTACCATTGACGTTCGGCCGCTCCTGAGTCACTTCATCG TATTTTTCGGCAAAAACAGGTATCGTATTATCTTTTGACTTTTGTTCCCATCATCTGGACCAGGTATCGA TCAGAATCAACTGGGGCTGTTTTATTTCGTTCACGATCAGGTGGTGCGATAACTTTCGACAAATTCATTT GATCTGCTGTGGTCCGTGTCTGTGGTCGGTGAGCATGTAAATAGTCTTTCTCCACCTTCCAAGTTATATA CACACATTACAGACAGCTGACTGCCCTTTGCTCTTTACCTATTCCTTAACAGCTAGGATCTATTGACAGT TCGTCATTGCGCAATTTTGCCCTTCACCGCCTCGCCCTCTTCCTATCATCCCTTTCAGCTTTTTCCCCTA ATTGGCTGCCCATATCTCGCATCTGACGGACGAAGCAAATTCCCTGTATCCCTTTTTACGGCTATGTATT CCTTTGAAACATCTCAGGAAGAGAAGCATATCTGAGATACCTACTATACAACACAGGATCTGAGATGTAG GTGATCTGCAGACAAATGCTTAATGTAAAGGCTGACTTTCTGAGCTTTCTAGCAGCATCTCGAATTGAGT TACAAATCACAGGCCTTTGATGGCGAGGCATCTAGAGTAACAAAGCGAGCATTCGAAAAAGAAGATCAGA GAACGCCGATGTGAGTTGATCTGGCGTTTCAACGTCTATTCGGATCAGAAAAAGGGAACAATGTCCTTCT TTATCCGCACGGACCTCTTGCATTCTTCTTCTCTCGCCTTCTCAGAGCTGACGTGAATGCCCGCCCAGCC AACGCGCACTCCGCCTCCCGCCAATCCTCATCCCGACTTGGTATACAATACCTTTAACGTCCTATATCCT TGTATTCTCCCCTCCCCACTCTATCCACTCGCCCTCCTTAGTGCATCAAGGACACACATAGTTGCACAAC TCCAAGGAGTCTTTTTTATCTTCTTTTCGATCCCATAATTGCCGTTCCCACTTTACACTATAATCGTCCT TCTCAAGCTTTCGGATTCTTACCGCAACGGCCGTCTTATTCAGTCGCTGGCTTTTTACGTCTAGATATCT CTTGTACTCAAAAGGCAACTTACACAGTTCCTGCACAGGGCACCGCCTGGGATAACCAGACTTCCTTGCC AGCACAGTCGTCAACTTTCTGCTTATTCTGAAACTGTGATCTGATCATTATGTCCAGTACTACCAACTCC CATCTTATGAAGACTACCCGATGGGGTAGGCCATTCGTCAAGGTCAGCTGCCATCTTATTTAGCATGGCT GTCGTTAACATCAAGTAATATCAGGACACTCATGATCTGTTCTGTACTTTAGTAGTCAGCCTGAATTTCG ATACACATCGAAACTTCTTCAAGGCCTATCCCAACAGTTTCACAACGTGGGTCTACCGTCATGGTTTGAA TGTAAAAGCTGACAACGGCAAAAGAGACGATGCTTGCTTGAATCTCGCCTCTCTCAAATTCTCCCAATCA ACGCGGACCGCCGATCCTAAAGATCCTACTCGTATCGTCACTACCACGACCACTACGACATTCTCAATGT CTCGCGAAATGGCCAAGGGTATTTGTCAACATTTTATGGATTGTCACCTTCTAGAGAACGCCACGGATAT TATGGCCGGCTCTTTCAAAGACAGAGGTATCTACATGTTGACTCCCAAAGGTCTCCATATTCTCGAGCGA TTTGTGTCTAAAAATGGTATCACAGCAGATCATCTCCTCAAGGTTTTTGCAACGCAACCAATCACTATGA AACTACTTCACCTCGAAAGACGATCAGGTGATGATGAGATCATCATCACACGGAGCGTCATTGAAGTCTT GTTCAGGCGTTTCATCGGTCGTGTACCCAACTCTACCAAGCTGAATGATGATGAAGTATTGGCGCATTTC TATTCTCGATTCTATACCAAGGCACCACCTCTTCCAACTGGCGAGACGCTTGACCGGTCAGAGGGTATCA TTGTCCGAAAACCTGGTGGAGGCGAGAAGACAACCTCATCGGATGATTACATCTTCTCAGCACGGGCCGC CGTTGACTGGATGCTGGATTTCACATCAGCAACCGGGATAGATGAAGCCGCAGAAATCCTTGCTCAGTTT GTTCGGTACGGGTTGATCACATTTGTGAGCGACAAGGGGAAGATCAAGGAGGAAAATTTGATTGTCAGCG TGCGAGGAGGGGGTGCCGGTGGTGGTGCCGGAGCTATTATGGCAAGTAATTTTCAGATTCATATGCTAGT GGAAAGCTAACAGCCTTATAGCCAGAAGCAGAGTTTCGAGTCACAGAGCGAGCCATCTACAAAATTACAA AAGAAGGAATTGCTGTTGCGAAATGGAACGAACCCATTACCAACCATGTGGCTGGTACTTCTAAAACCAA CCTTTGCGTCGAAATTACCCCAGGAAATAAAACCAGACCTTCCCACGAAGCGAGCCCCTCTGTTTCCGTA CAACGTCGCACATCATTGTCTGATCGCTTCCGCGGCGACTTTGATATTTCTGGTGTACCAGGTGGCGATA ACCACATCAAGGATAGTCATACAGCGCGACTAAAGCAGATCCTCGAGGAACCTGCTCTGAGGAGCTTGTT CCGTGAATTCTTGAGGAGCAATTTCTGTGAAGAGAATTTGAGCTTTTGGTTGGATGTACAGGATTTCAAG AGGAGATTCCAAACGACAAGCTCGGCGGTTGCAGCACCAGGATCGAAACAGGCAAAGCTCTCGGGTCATG CAGCAATGGAAAAGCATCAGCAGGATTTGATTGCGATGGCCTTTGTCATCTACAACAGTGAGCATTGCGC TAAATCGGTATTCTGTCAGTAAAATATCCCTGACATTCCGCAGCCTATCTCGCACCCGCTTCTCCTTGTG AACTCAATATTGACCACAACCTTCGGGCCGAGTTAGTCTCTTACATGAACCAGATCACAGCCGACAAGGA AGCTGGAGTGAAGGGTCATATCGAGCCCGGTGTTGGAAACACCTTACATGCTAGTCAGCTGCAAACTATG GTCAAGCTTTACGAGAGAATCCAGGTGTACATCTTTAGACTGATGGCGACCGATTCGGTACCCAAAGTAG GTCTTGACTTTATATATGTAATGAAAGGCATGTGCTGATAGGTCATGTTTCTCATTTATAGTTCTGCAAG ACTGAGCTTGTAAGTTCACTTGCCCCATTCTGCCTTTTAAACAAGTCGTCCCTACGGCGGAAAATGTTTT TCGAAATCGCTTGGCTGATGCGGAAATATGTTTAACCCAGTTCCTCACCCTCATGCAGCAGTTCTCAGAG TACACAAAAGAGGAATCCGCCGTCACCAATCTTGAATCCAAGGCAGCTGCTCTGATCGTGGATCCACGCA AGGCTACAACTCACGCGGATGAGCGCCAGCCCAGTCCTACTCGCTCTTACCTCACAATCTCTCAAGTAGG TTTATTTCTGTTATTCGAGAACGATCGCGGTGCTGATCAATCTAGGCTGCAAATGAGAAGCAAGCTGCTA AACAAAAGCACTAGACAATCCAGTTTTGCTAATATCACCTGCGTGTTCAGCTGGCTGTAATCGCTTTTCT TCCCGATCTACCTTCCCACGCGTATTCTATAGATGCATCGAATTCTTCTTACCCTCATCGTTACTTCATT ACATTGTGCGTATATATCCTATCCTCTATTCACTCCCCCCCCCCCCCCGGTCTATCTAGCGCTATCTGCT GTCTAGTACTTTATCCACGTTCTACTTTATTTACCCGTCAGCAACCATAATCATTATTGCATATAGTATC GTAATCGTAGTTTTGTTATAGTATTGTTTGTAGGGTTTCGTCGAGTTTTGGTATGAATTGACACAATCAT ACGGCG
Protein Sequence	>gi\|799312412\|ref\|XP_012046183.1\| hypothetical protein CNAG_00125 [Cryptococcus neoformans var. grubii H99] MSSTTNSHLMKTTRWGRPFVKDTHDLFCTLVVSLNFDTHRNFFKAYPNSFTTDDACLNLASLKFSQSTRT ADPKDPTRIVTTTTTTTFSMSREMAKGICQHFMDCHLLENATDIMAGSFKDRGIYMLTPKGLHILERFVS KNGITADHLLKVFATQPITMKLLHLERRSGDDEIIITRSVIEVLFRRFIGRVPNSTKLNDDEVLAHFYSR FYTKAPPLPTGETLDRSEGIIVRKPGGGEKTTSSDDYIFSARAAVDWMLDFTSATGIDEAAEILAQFVRY GLITFVSDKGKIKEENLIVSVRGGGAGGGAGAIMPEAEFRVTERAIYKITKEGIAVAKWNEPITNHVAGT SKTNLCVEITPGNKTRPSHEASPSVSVQRRTSLSDRFRGDFDISGVPGGDNHIKDSHTARLKQILEEPAL RSLFREFLRSNFCEENLSFWLDVQDFKRRFQTTSSAVAAPGSKQAKLSGHAAMEKHQQDLIAMAFVIYNT YLAPASPCELNIDHNLRAELVSYMNQITADKEAGVKGHIEPGVGNTLHASQLQTMVKLYERIQVYIFRLM ATDSVPKFCKTELFLTLMQQFSEYTKEESAVTNLESKAAALIVDPRKATTHADERQPSPTRSYLTISQAA NEKQAAKQKH
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: The regulator of G protein signaling homolog Crg1 is a key regulator of pheromone-responsive mating in Cryptococcus neoformans. A mutation in the CRG1 gene has greatly increased virulence (Wang et al., 2004).
References	*Wang et al., 2004:* Wang P, Cox GM, Heitman J. A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans. Current genetics. 2004; 46(5); 247-255. [PubMed: 15503029].


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CRG1