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CPL1

Victor ID 5295
Gene Name CPL1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23887151
NCBI Protein GI 799318261
Locus Tag CNAG_03675
Genbank Accession CP003821
Protein Accession XP_012047380
Taxonomy ID 235443
Chromosome No 2
Gene Starting Position 505913
Gene Ending Position 508519
Gene Strand (Orientation) +
Protein pI 8.94
Protein Weight 71539.84
Protein Length 688
DNA Sequence 
>gi|799350600:505913-508519 Cryptococcus neoformans var. grubii H99 chromosome 2, complete sequence
TGGAATATGAATCACGTGATCTCCCCATGGCCATATCGGAGAATGGTGCCTGGGTTCAAGATTTCTTGAA
CATGGCCGTTCGAGCAGGTTTTCGACCAAAAGCCGGTAACTTTCTATTTCTTTTTTGATTTGCGTTGATT
TGCTCTAAACTCAATCAAAAATGGCCCCCAAGGCAGTCCAGAAGAAACGTTCAGCTCCCGATGCTGGTTC
GGCACCTAAAAAGGCCAAGATAGTCCAGTCTGGCAAATCTTCGAAGCCTGCAGCCCAAAAGCAATCTAAG
CCTCGATCTGCTCCTCGCGAACGAGAGGAAGAGGCCAAAAAACGTAAGAAACCTATCACCCAGGGAGGCG
GTGAGGAAAATGAGGATGTGAGCATGGACGAGGGATCATTCTCAGATGAAGACCAGGAAGATCAGGAAAC
CGAACGCAACGATGTCGAAATGGATGATGGTGACGCCCAAGAGGCTGCCCCTGAAAAGAAGCGTCTGTCA
AAAGCCGAGAAACAAGCCCTTCACGCTGCTCAGCCTCACAGGACGACTCTCTTGCCTTCCCATCCTCTTT
TGCACGACACACTTTTACCTCTGTGGGAAACTGCCAGGAGAGCCGATTTGAGTAAGGAGGAGAGGAAGAA
GGCTATCACTGAACTTTGGGAGGCTGTCAAGGGGAGAGTCATTGAGGTATCCAGGGGTCATAAAGGTGGT
CGAGTATTACAGACTGTATGTCCAGTTTATTCAAATTTTGAATGACGCTGACAAATTACTAGATTGTCAA
GTATGGCGGCAAGGAAGAACGTCTGGGCGTTGCTATGGAGCTTGAACCCCAGTGGAAGGCAATGATGGAA
TCCAAGTACTCCAAATTCCTTATGTCCAAGCTCATTCGATATTGCCCATCTATTCGCCCTTTGCTCATTC
CCCATCTGGCCCCTCAACTTCTCAATCTCCTTAATCATGCACACGCCGTCACCCCCCTTTCCGACCTCTA
CGAGCTCTGGGCATCCGCCAAGGAGCGTAGACTGCTTGTGAGGGGATTCTATCCCAGGGAAGTCAAAATC
TTCGACGGTGCTAAGCAGGGTGTTGAGGTCAAGGGTTTAGAGGCGAGTTTGGAAGATATGGGTGAGGGTA
AGGGCCGGGAACGGGTGCTGGACGCTATTGAGAAGACCGTCTTGGACGTCTTCAACGCCACTCAAAAGAA
CGCTCTTGGTCAAGCTATCTTCCACCGCCTTGTTCTCGAATATGTCCAGTGCATCTACAAATTCCTTGAC
GCCGAGACTTCTTCCAAAAAGATGCACGAGCTGTTAGCCGCTGGTGCCGAAAGTTTCCCTGAAATTGTCC
ACACTAAAGATGGTTCAGCTGTTGTCCGAGAGTTGATCGTCAGAGGGAATGCCAAGGTCAGTGTGTACTG
ATAACCATATCACTCGTTATGCTAACACAAAGTGATAGGATCGTAAACAAATATTGCAGCCTTTGAGGAA
GCATGTCGAGGCACTTTGCAAAGACGGCGATGCCCAGATGGTCCTTTTCACTGCATTCGACTGTGTCGAG
TAAGTGTTTCCAGCCTGATCACGTTACATCTGCTAACCTGATCCCTAGTGACACAAAGCTTATGGGCAAA
GCCTTTGTCTCTGACATTGTTTCTCTCGCTCCAGAACTTGCTTTTGATAAGCATGGCCGACGTGCCATAT
TCTATCTCCTTACCCCTACCTCTACCCGTCACTTCATTCACGCCTCCCTCACTTCCCTCGCTGAGTCGGC
ACAAAAATCCAAGGAGCTTGGAACTAGCAAGAAGGGCATGGATGTGAGGCGCAAGGAGCTTTTGAGCTAT
GCCAACGAAGGGCTTGTGAAGCTTGTTGAGGAAAAAGGAGAAGAGATGGTTAGGGACCCCGGAGCTGGTT
TGGTCGTCCAGGAAATCATGCTTTATGCTCAAGGCGGTAAGTTCTAGTTAACTTTCTTTTTAGGCCACAG
AAGCTCATTGTCGATCACAGACAAGAGTGCCGCTATCCAGACTCTCGCGTCCGCCCTCACCCTACCCTAC
CCTGACCCCGCTCCTCTTGACCCCAACCCTGACCCTACCGTCTCCCACCCTCTTGACCTCTCGCACGCTA
TTCGTACCTATAAGCTCCTCCTATCCGGCGGTCATTTTGATCACAAGACACAAACACTCTCTATTCCTGA
TTCCTCTCTTTCTCCCGCCTTTTCACGTGCTGTTTGGGATGCCCTCACAAGTGCTGAGGCCGGCGGTGCG
GAGAACGTTGGGAGGGTCTGCAAAGGTAATGCGCCGTTTGTGATGGTCGAGTTGATTGAAGGTATGAAGA
AGAGAGGAGATGGAGAAGAGGTCAAGAAGATCTTGGGCAAAAAGGGAGTTAAGGAGACTGTTGAGAAGAG
TGTTCGAAAGGGAACGGCTTTGTTGACGGAGAAGATTGGGGAGCTTTAGATTTTGGTATATACGTTCTGG
AGTGTAGCTATCATCATGGTCTGCATTGTTTTTGTGTACTCGAATTTAAGCCTGCTTGACTTTAAAGGGT
CCGGCCGATTTGATATCCGTGTAAGTGTATCTAATAGCTTAAAGAGTACATGCAAGGAGACCCTGTTACA
CTAAAGAATGAATTTGT
Protein Sequence 
>gi|799318261|ref|XP_012047380.1| pumilio domain-containing protein [Cryptococcus neoformans var. grubii H99]
MAPKAVQKKRSAPDAGSAPKKAKIVQSGKSSKPAAQKQSKPRSAPREREEEAKKRKKPITQGGGEENEDV
SMDEGSFSDEDQEDQETERNDVEMDDGDAQEAAPEKKRLSKAEKQALHAAQPHRTTLLPSHPLLHDTLLP
LWETARRADLSKEERKKAITELWEAVKGRVIEVSRGHKGGRVLQTIVKYGGKEERLGVAMELEPQWKAMM
ESKYSKFLMSKLIRYCPSIRPLLIPHLAPQLLNLLNHAHAVTPLSDLYELWASAKERRLLVRGFYPREVK
IFDGAKQGVEVKGLEASLEDMGEGKGRERVLDAIEKTVLDVFNATQKNALGQAIFHRLVLEYVQCIYKFL
DAETSSKKMHELLAAGAESFPEIVHTKDGSAVVRELIVRGNAKDRKQILQPLRKHVEALCKDGDAQMVLF
TAFDCVDDTKLMGKAFVSDIVSLAPELAFDKHGRRAIFYLLTPTSTRHFIHASLTSLAESAQKSKELGTS
KKGMDVRRKELLSYANEGLVKLVEEKGEEMVRDPGAGLVVQEIMLYAQGDKSAAIQTLASALTLPYPDPA
PLDPNPDPTVSHPLDLSHAIRTYKLLLSGGHFDHKTQTLSIPDSSLSPAFSRAVWDALTSAEAGGAENVG
RVCKGNAPFVMVELIEGMKKRGDGEEVKKILGKKGVKETVEKSVRKGTALLTEKIGEL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The CPL1 gene is required for capsular formation and virulence (Cai et al., 2015).
References
Cai et al., 2015: Cai JP, Liu LL, To KK, Lau CC, Woo PC, Lau SK, Guo YH, Ngan AH, Che XY, Yuen KY. Characterization of the antigenicity of Cpl1, a surface protein of Cryptococcus neoformans var. neoformans. Mycologia. 2015; 107(1); 39-45. [PubMed: 25261494].