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CMT

Victor ID 5291
Gene Name CMT
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23884503
NCBI Protein GI 799313444
Locus Tag CNAG_00721
Genbank Accession CP003820
Protein Accession XP_012046408
Taxonomy ID 235443
Chromosome No 1
Gene Starting Position 1878926
Gene Ending Position 1881468
Gene Strand (Orientation) +
Protein pI 6.86
Protein Weight 57033.31
Protein Length 525
DNA Sequence 
>gi|799350543:1878926-1881468 Cryptococcus neoformans var. grubii H99 chromosome 1, complete sequence
AAAAAAAGGTTCCGCGGTTGTTCGGGACGCGATCCTCGTCCAGACAAGTGCATCTCACCTTCTCCCCCTC
TCCCCCATCTCGCACCCGCAGCCCCTTTTGCGGTCCCCCCTCCCCCCACCGCCGCTCGCTCCCCTCTCCT
CTTGCCCCCACTGCTTCGACCCTCGCCCCCCCCCCGCCAGAACATTTCTTTCCCCGCCATGAAACCCGTA
GGATCCCTCTCCTTGGGAAGAAAACTCCCTTCAGCAGGATCTCTGCTCGTCGGTATCCTCGTAGGGCTGC
TCGTTGCTTCAGTATGTCTCCTATAGTCCTTCCAGCGCCCAACTCGCAACTCGCTTCGTCTGCAGGGAAA
GAAAGCTGACTCGTGTTCGTGTGGTAGCTGTTACGTCGAGGAGATGTAAGTTTGGCGCGGCCAACCGCTC
TCCACTTTCCACTTTCCAGCTATATATCACTGACCTGGCCTCACAGTCGAATACCGAAACATGGCGTGGT
AGTGGTGTGAACAAGCTGCGGCCCAACCCCGTCGCAGGCGCTTCCCGTCTACAGCGCTCCCAGATCATGC
TCCCCTCCATCGAGCAACGTCTCCATATCCTCGAGCTCATCAGCACCCTCTCCGCCCACCACACCAAGGA
ATGTCTCCGCAACCCGCAACCTCTCTACGTCGAACAAGTCAAAGAACGGTACGCGCCTCTTGTCGGGTAC
AAGAAGCCTTGGTCCAACTCTGGCTGGTTGGGCAAACTGTTTGGCGGTAAGAGTGATTCCCACCTGACCA
TGGCGTCGACCACTGGAAACGACAGGATGGACAGTATCAAGCGGGATCTGCAAGCGAGGCAGCACAAGTA
CTTCTTCGCCATCAACCTGTACAACTCGTTTGACGTTATCCCTGATATCTTTGCGACACTCTTCCGAGCA
GCTGCCATCTTGGGCTACCACAATGTCTTTGTCTCCATTTACGAAAACGGTTCCAACGACCAGACAAAGG
CACTCTTGAAGATTTTTGATGCCCTCGCGCGAACGGTCGGTCTGAGGATCATCATCCGAACATCTATGCG
TACCCGCGGTCTGTTCAACCATCGTATCGAATACCTCGCCGAAGTTCGAAACGCCGCCATGCTGCCCCTC
CACGAGCTTCGTGACAATGACGGAGAAGTCTTCGACTCGGTCGTTTTCATGAATGATATCTTGCCTTGCG
TGGACGACTTGCTCGAGTTGATTTGGCAGAGTAGGAGACAGAATGCGGGTATCACCTGTGCGGCGGATTA
CATGTACCACGATGATATCGTGAGTCCTGTCCCCCCCTGTTATTCATTATCATCACTTGGAAACGAAAAT
TACTAAACAAAACAAACATCATATTACTAGGGTGCTCCTGTATTCTACGATAACTGGGTCGCCCGTGATA
TTAACGGTACTGCGCTCGAGAATGCGCCTTTCGAGCAAATCTTCCACCACACTGAATCCAACCACCGATT
CCAGCGACATTTGCCCATCCAAGGTGAGGTCGCTCGGGCGCCCGGGCTACAAGGCGGGAATAATAAACGC
TCATCTGTGGGTTTTATATATAGTCCAATCATGCTGGAACGGTATTGCTGTTCTCGATCCCACTCCCTTT
TACGAACCTCCTCATGTCAAATTCCGAATGGCCCACTTGGATCAAGGCGAATGCTCTGCGAGTGAATGCT
CTCTTATCTGCAGTAAGTCTATTTTTCATTCCCTTGGATTGTGCACCTTTTTTTTTTTTTTTTTAACCAA
CCTCTTTTTTTTTTTTTTTTTGTTATGACAGATGACTACTTTAACGCCGGGTATGGACGTATCATCATGG
TCCCCCGAGTCAAGCTCGCCTACGACCGAAAAGTTTGGGATATTATCCACCCCGAACGAAGAAACCTCAC
TGCTATTAGAGGCTACAAGCGTATCGGCGGTTTGCCGGATGACCCTCACTCCGATCCACAGGACAGGAGC
TGGTACGGCCCGCACGATAGGTTGTTCACCCCTGAAGAGACAGAGGAATTGGAGTTTGTCCCCGGACCAG
AGTATGGTAAGTCGATTTATACATTGTTTATCTGCACGATGGGGTTATGTGCTTATAGAGATTGTTCAGT
GTGGTGCTGGGGTTGGGACGGTGCTGGTGATCTTGATGGACCCGATGTGGACCCTATTTGGGAACACATG
CAACCTAGGTCGTACTCTGAAGAGGCAATCCAGATCAAGCATTACCGAAATATGCCTGGATGGTAGATTT
CTTAAAGAAAGATGTGTGAGTGTTTTCGCCTGCAGGGAGAAGGAAAAAAAATCGTTGCTGACGAAGGGAT
GAGAGTAGAGATTGGGGAGAGTTTGGTTCCGATTATTACATTTTGATCGAATCTATTGCTTGTGCTTTTG
GAATATGCATACCTTTTTTTAGACATTTCGACCCAGTCCCATGTGTTTTTTCTTTTTTTGTTTTTTTTTT
CCGTCGTCTCGACAATTTAACATGCCTTGCTTCTTTCCTAGTCAATCGTAGATAATGAGTCAAAATGCAT
GACAAGAGTCCTTTTAAGCCTGG
Protein Sequence 
>gi|799313444|ref|XP_012046408.1| alpha-1,3-mannosyltransferase [Cryptococcus neoformans var. grubii H99]
MKPVGSLSLGRKLPSAGSLLVGILVGLLVASLLRRGDSNTETWRGSGVNKLRPNPVAGASRLQRSQIMLP
SIEQRLHILELISTLSAHHTKECLRNPQPLYVEQVKERYAPLVGYKKPWSNSGWLGKLFGGKSDSHLTMA
STTGNDRMDSIKRDLQARQHKYFFAINLYNSFDVIPDIFATLFRAAAILGYHNVFVSIYENGSNDQTKAL
LKIFDALARTVGLRIIIRTSMRTRGLFNHRIEYLAEVRNAAMLPLHELRDNDGEVFDSVVFMNDILPCVD
DLLELIWQSRRQNAGITCAADYMYHDDIGAPVFYDNWVARDINGTALENAPFEQIFHHTESNHRFQRHLP
IQVQSCWNGIAVLDPTPFYEPPHVKFRMAHLDQGECSASECSLICNDYFNAGYGRIIMVPRVKLAYDRKV
WDIIHPERRNLTAIRGYKRIGGLPDDPHSDPQDRSWYGPHDRLFTPEETEELEFVPGPEYVWCWGWDGAG
DLDGPDVDPIWEHMQPRSYSEEAIQIKHYRNMPGW
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Mutant strains lacking CMTs or expressing Cmt variants defective in Cu-coordination exhibit severely attenuated virulence and reduced pulmonary colonization (Ding et al., 2013).
References
Ding et al., 2013: Ding C, Festa RA, Chen YL, Espart A, Palacios Ò, Espín J, Capdevila M, Atrian S, Heitman J, Thiele DJ. Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. Cell host & microbe. 2013; 13(3); 265-276. [PubMed: 23498952 ].