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CLP1

Victor ID 5290
Gene Name CLP1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23885768
NCBI Protein GI 799330070
Locus Tag CNAG_02111
Genbank Accession CP003825
Protein Accession XP_012049851
Taxonomy ID 235443
Chromosome No 6
Gene Starting Position 1156952
Gene Ending Position 1160138
Gene Strand (Orientation) +
Protein pI 4.74
Protein Weight 55551.39
Protein Length 547
DNA Sequence 
>gi|799350727:1156952-1160138 Cryptococcus neoformans var. grubii H99 chromosome 6, complete sequence
GTTTGTCTAGTTTTTCTACAGTTTCGCATCTTCTCTCTCCACTTCATATTATCTTGTAGCCCCGCATAAA
TAGAACATACGTATATAGTATAAGCATAATGGCTGAACAACAAACTACTGAACTCACAAATATCGATCTC
GAAGCCGGATCAGAATGGCGATTTGAACTCGAAGCAGATGAAAACATTGCCCTTAGAGTGAGTCTTCCAT
TCGGCTGCGCGATAAGCATAGTATATATACATCATAGCATGTAAAATGGTTATAGCTCTGTGAGTGGAAA
TTGCTGTTGCCATCGTGAATCAAGCTGATGAAAACCCCGTCTCGCCGTCTCGTTATTTTACTGATTGCCT
TGGTGTCAATGTTTTTACTCTGAATTGTTGTTCATGTAGTGTAATTTGGTATGCCATCAGAGCTTTATTG
TCCGCTTTCTGGACCTTTCAAGCTCATTTGCTTCATGTTGTGACCGCTGGTCTTGTGATATGGCTTAGTC
CAGTGCAAATCATCAAAACTCTCCGCTGTCGCCTCATTCGAAATATCGCCTTTATCATGACGTGACTGTA
CTCACCGGAAAACTGACTCCTGATGCAGACTCTCTCTCCCGATCCAGTCTTTATCAACTCTCAAGAGCTT
ACTCCTTCGGCATGGTATCCGATCTATCGACACACAAAATCCGCGCTCTATGCCCCGACTCCTGCCAGAG
TACAGGTGACAAACCTCCCGGCATCCCATTATACATCCACATCTACAGTCCAACCCCAGCTATTGAACCT
TCATTTGGCAATGGAGCGCCAGCGAATATTGTCCAGGAGAGGAATGGAACAGAGGGGGCCCCGAGTGATG
ATCATGGGCCCTCAAAGTTCAGGAAAGACAACAGTCATGAAGAACTTGGTCAATTTGGCTTTAGGGACCG
GTATGGGCTGGACACCTGGTGTGATTGGTCTGGATCCGTCAAGCGTAAGTCTATAGAAGGTTGTGAGGTA
ACAGCAGAGACTCATCTTTGACAACAGCCTCCTAATCTTATCCCGGGAAGTTTGTCCATCTCCACACCGT
CACATCCGATCCCTACCCATCATTTGGCTCATCCCTTAGGCTCACCTCCAGCTTCTACTGCAGCCAATAC
TGTCTCGGGAGATGTAGAAACAGCTAGCTGGTGGCTTGGAGCTCTCGAACCGACAAACAAGAATGCTGAA
GTATGGCGGGTTTTGGTTGAGCACATGGCAGAAGCTTGGGGAATGAGATGCGAAAAAGACAAGACAGGTA
TGTATTACCATTGGATGGCTTGAAGAGGAATCTCACAAAGACATTTTGTAGCAAACATCTCTGGCCTCTT
CCTCGATACTCCTGCCGCATTCACTGTCCCTACTCTCGGCACCAAGAAAGACGACCCTAAAGCTCGATAT
ACTTTGGTGAGCCACGCTATCGAGGCGTTTGATATCGACACCATCATCGTCATTGGCCACGAAAAGCTAC
ACATTGATCTCTCCCGTCTTCCCCTCGTACAATCCCTCAAACTCAACGTGATCCGTATTCCTAAATCAGG
AGGCGCCGTCGATCTTGATGACCACGATCGCGAGACCGCTCATCTCTTCCAAGTCCGAACCTACTTTTAC
GGTGAACCCCCTCTCCCGCCACAAATCTCCGGTCTGGTAGGGAAAATGGTGTCTGTCGATTTCGAATTAT
CACCATACTCGTTCCAGATTCCGTGGAGCAGGCTTGTCGTCCTCCGCGTTGGAGAAGAAAATTCGGCCCC
GTCGTCGGCCTTGCCTCTTGGCTCCAGCAAGGTGCTTTCACCTTTAAGATTGACGAGGGTGGATCCCAGT
GGACCTGGACATGTGGTGAGACTGTTGAATAGAGTCTTGGCGTTGGTGGATGTCAAGCCTGAGGATAGGA
TTGTGCCGGCGAAGGAATCAGAAGTAAAGGAGGAAGTGAAGGAAGAAAAGTACGAAAAGGATGGGGAAAT
TAAGCAAGATGGTGAAGGAGAGAAGAAAGGGGAAGGGGAGAGCGAGGGAGAAGGAGAAGGAGAAGGAGAA
GGTGGTGAGGGAGAAGGTGAAGCTGAAGATGAGGACGATGAGGAAGTACCGTTCAGGGAAGAGATTGGTA
CAAGGGAAGTGATGGGTTTTATCGTCATGCAAGTCTTTTACCTCCCTCTTATATTTCCTATGCTGACTTA
ACATGCAGCACTGCCATAGATACGTTCGCTCGTAAATACACCGTGCTATCACCCACACCAGGTCGTCTGC
CAACTACGGTTGCCATCGCTGGCGCTATTGAATGGGTCGACTCTGCTTAAGATTGCACCATCAACATTAA
CAGAAAACCGCATCATAGATTAGCACAAGCGTAGATTCACATCAAATAACCATGCCAAGCATGTATAATG
CTGTTAACGCGCCCTTTTTGAATCGTCTATATCTTCTTGACATATCTCGCTAATAAATGGCTTAAACATC
CGCCTTACCCTCCTTCTCCCCCTCCCCCTGAGCCGCCGCCTCCTTGGCCAACTCTTCTTTCCTCTTCTCC
TTTTCTTGCTGTCCCTTCAAAACCCACGCCAAAGGCGCCTTTTCCACAAACATCCGTCTCAACTCTTCAG
TCTTTTCAGTCCCGGCTTTAGCCTCTGCAAATATGAGCGCCTCTTGCAACGTCCTGATATCAGCCTGTAC
AGAAACAAGGGAACGAAGAATGTTGATAGCGCCATCCACATCCTCGGAAGCCACTTCCAACCTCCCCTTG
GCAGCGCCCAAAAGACCTTTGGCGTCGCCGGCAGCCTTTTTTGCTTCGATGTATTCTGCGTTGAACGCCT
CTGGGGACTTGCCGGTGGGCAAGAGGGTGGGTAAGGATTGCTTGATGGTAGATACGAGGGTCTCGGGGAC
ATCAACTGGGAGAGAAGATGCGAGACGGTTGAAAGCGAGGATCTGGACGTGGAGGGTGGGGTTGGAAGGG
GAGAGTGCTTGGGCTTGAAGAAGACATCGGAGGGCAGCGAGATACATTTCTATTTCCCAATTTCCCTTTG
TCAGCTTACCTCTAAATAGCCAAAGGAGCAGAAAATAAAACAACATGTAAAAAGACAAATCTACTCACTC
TTCCTGATGTAAATCTCGTAACCAGCCAACCAAATTTCAACTCTCTCACCCTGTTTCGCCTCCAACGGCT
TCCACAGCTTCAGCGCATCGTCCAACAATGTCTCGCT
Protein Sequence 
>gi|799330070|ref|XP_012049851.1| protein Clp1 [Cryptococcus neoformans var. grubii H99]
MAEQQTTELTNIDLEAGSEWRFELEADENIALRTLSPDPVFINSQELTPSAWYPIYRHTKSALYAPTPAR
VQVTNLPASHYTSTSTVQPQLLNLHLAMERQRILSRRGMEQRGPRVMIMGPQSSGKTTVMKNLVNLALGT
GMGWTPGVIGLDPSSPPNLIPGSLSISTPSHPIPTHHLAHPLGSPPASTAANTVSGDVETASWWLGALEP
TNKNAEVWRVLVEHMAEAWGMRCEKDKTANISGLFLDTPAAFTVPTLGTKKDDPKARYTLVSHAIEAFDI
DTIIVIGHEKLHIDLSRLPLVQSLKLNVIRIPKSGGAVDLDDHDRETAHLFQVRTYFYGEPPLPPQISGL
VGKMVSVDFELSPYSFQIPWSRLVVLRVGEENSAPSSALPLGSSKVLSPLRLTRVDPSGPGHVVRLLNRV
LALVDVKPEDRIVPAKESEVKEEVKEEKYEKDGEIKQDGEGEKKGEGESEGEGEGEGEGGEGEGEAEDED
DEEVPFREEIGTREVMGFIVITAIDTFARKYTVLSPTPGRLPTTVAIAGAIEWVDSA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The deletion of CLP1 leads to a block in sexual development after cell fusion but before filament formation, and cells without CLP1 are unable to grow vegetatively after cell fusion (Ekena et al., 2008).
References
Ekena et al., 2008: Ekena JL, Stanton BC, Schiebe-Owens JA, Hull CM. Sexual development in Cryptococcus neoformans requires CLP1, a target of the homeodomain transcription factors Sxi1alpha and Sxi2a. Eukaryotic cell. 2008; 7(1); 49-57. [PubMed: 17993575].