Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

CIN1

Victor ID 5289
Gene Name CIN1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23890540
NCBI Protein GI 799336891
Locus Tag CNAG_07718
Genbank Accession CP003827
Protein Accession XP_012051371
Taxonomy ID 235443
Chromosome No 8
Gene Starting Position 345596
Gene Ending Position 352431
Gene Strand (Orientation) -
Protein pI 5.59
Protein Weight 205863.16
Protein Length 1934
DNA Sequence 
>gi|799350780:345596-352431 Cryptococcus neoformans var. grubii H99 chromosome 8, complete sequence
TTTATCTTCGTGCCCTTGTCTTTCCTGCGATCAAATCATCCTACGAACACTGCGGTCAGCAAACGTATCA
TCCTAAGGAGATCAACAACTCACTATTAGTCGTCAAAACTCTTTTCCTCGCTTTATCAATCTTCCGCATC
CAATCTTTCGCGTCACTGGCACTTGCAGCCCTACGAGTCCCGTTAGCTTCATTCAGTCGTTAGAAGATAA
TGTACACACCTGAGGGCAATAGTATCCCCTCCCCTTCTCTGGTCCGCCTTCAGCGCGAAGCCCGTCGAAT
CTCTCGTCTGTCGCACTTCAACCTCATGCAATGCCAATGGCTAAACGATTGCCATCAGCCCTTCATCCCC
GAGCGCTCAGCGAAAAAACATACCATGCGGTAAAGACTTTTATCCTCGAGAAGGACGATGATATCGTTAC
ATAGAACCATGCTGAGTTTCCTACCTGACTTGGCCTTGGATATAGGCCCCTCTTTGATAAGCTTTCTAGG
GCCGAGGAACGCCGTTGGAGCCGTTAAATCAAGTCGTCTAAATATACGTAAATTTCCCTCTTCTAATATT
GGGATCAAGGACTCACCCTTCGCCTCCAATCCACAGATTCTCACTCAATACTCTCAATCGTTCTTGCCCT
TCCGCTTCCCTCACGCTCTCGTTGATCCTAGATACAATCCCTTCAACTGCATGCAATACCGATTGGAGAG
GGGGTAAATCGGACGAGTCGTAAGGAGTGTAAGCGATGATTTGCTTGATAAGAAGAGGGTAACGCGTTAT
TCGTTGCACTGAAAATGAGGGTCATGATTAGTGAAGAAGTGATAAACTGTATATGTTATTTACTCGGTAT
GAGGAGATAATGGGAAAGATCGAGGCCTCGAATAGAGCTGTTGGTCGCTTGAATGTGCTATTGGGAGTCA
ATATGTCTCATATTTGCAGTATGTAAATGCACCAACCCTCAAATGGGCATCCAGCTCAGGCTTCTCCTCC
CTCAGGCTCTGTAGAAGCTTGATAGCTTGGTGCTGATTCACACAGTAAGTCTACGATTCTTGTCAGCTAA
TGATTACCTGAAAAAGATGCTTGAAGCTCAGCGCACCATATATACTCCAGCTTCATTGAGAAAACTCAAC
ACATCACCGATCCTGTCGATATACAACCTTGCTGCTTTTTGCCTCTCTTCCAAAGCACTGAGAAATCCAG
TATTGAACAAAAGGATGTCCTCAATGTTGGCAAAGATGACAGTAAGAGCTTTCTCGTCCAGCAGAGGCAA
AAGAGAGGCGTAAAACACCTGTGAGAGGGCAATGAGCATTTTAAAATAGATAGAATAGTGGTTCTTACCT
CCACGATCAATTGCAAATCTCTATTATAACCAATCTCAGTAGCGATGAATTCAAAAATCGCTTCTTGCCT
CTTTCTCTCCCTCTTATCCATCGTTTCTAAAACACTTGGTTCTACCAGACTAGACCAAGTCTTACCAAAC
CCAGCATCTACTTCTTCACTTGAGGTGAAAATACCTGATCCAGGTGCCGGGGAGGCAGGAGGTTCATCTA
CCCTCGTAATCGTAGGACCGCTAATGGATGGACGTTTAGGTTCATGTCCATGTGGCGCCATCATGCTCTT
GAAAAAACCGGTGATTTTTCCGCCTGTCTCCTTACCGAGTGACAGGGTGGAAGTGGGAAGAGAAGTTGTG
GTTGATGCAGAAGATAGAGCAGCTCCCTCTGCAGGCCCAGTAAGTTGAGGAGAAAGAACCTGGGATGACG
GCCGAGATTCGGCCCGAACTGGTTCAGGTCGAGGTAGAGGTTTGGATTGAACCTGAGCAGACTGGGCGAG
GAATGCCTCGTACCGGGCGTACGCATCTCCTGTCTCCAATCTGCCTGACTGAAGTTCTTTCGATGAAAGG
CTAGGTAGTTTTTTGCTTTTACCTTCGGGCACTGCTGGGGCGTGTCTTTTCTTTCTGCCTGGGACGTTAG
GAGCTGGTCTTCTTCTGGATACAACTCGCCCAAATCTTTGCGCGGGCGCTCCGGATGGCTCACGCTTGAG
TTGAAGGCCAGTGGCAGCAAGAATAGCCTGGCGTTGTTCTTCACGCTTTTTACGCTCAACTTCCTTTTCA
GCGTCGGTTTCCTTTTTGGGAGGTTTGGGCGCCGCACGGCGTTCCTTCTTTGGCTTCTCAATGTCGGCCA
CCCTATCATCTGTAGGTGGTTCCTCTTCAGGTTCATTCACATCTTCAGATTCAGAACTAGACTCGTCAGA
AGACCAAAAGCTAAGTATTGAGTCATCAGATGAAGATTCCCCTTCATCCTCTTCATTGTCCGTGATGAAC
GATGGTGTGTGCGACATGGCCGTGCTCGCTATTGAGAGCGTTGAAATGGCTCTAGGACGGGAGCGAAGCG
GAGGCGGGATACTGTGAACGCTCAGTCTATGTGAATCCTCAGTGGGTTGCAGTGAGTCCGAGATTTCGGC
TCCCTGGTATCCTTCAGCTGGCAGCTTGAGTTGTTCCATGGCGTTGGTGACTTCCGGAATCGTGGACATT
GGTTGCGCGTCAGTGTCAGTAGGAGCCGCTGGCTCAGGACTGACGCCTAAGTTACCGTCTCTTGCACCAT
GAGCAGACACGACTCCTGAAGCTTCGTTAGCTATATTACCGACCAGACGCATAAAGTCGTGCATAAAGTC
GCATTCCAAAGTAGAGATTTTTTTGATATTTTGGAGTTTTTGTTATAATGATCAAGCATGAAAAGAAAAA
TAAGAAACACAGTTTCAGCCTGCGTCAAACCACAACGGTAAACGAGCGATCCTTTGAGGAGTGGGGGTAT
AAGAGGAAAAGTAACTAACCATCGATAACTTCTAAGTATGCAGCAGGCACAAGGAAGATGATGCCAGTGT
TTTCGACCTTCCACCAGTCATTTTCGGATCGGTCAACGACTTCGAGGATGTCCCCTTCAGCGAAGGGCAA
TTGGTCGGGGTCGCCAGCGGCGTAGGAATAAATGGCTTTCGCGTGCACAGCTATAAATCATTTAGTGCTT
GTCCTGACGTTTATCAGAAGCATGGAAACGCACCCTGAATGTGCTCGACATAGTTCTTGGGGAACCAACC
CTTACTGCCGTCTTTCACCACGGTGCCATACCACCAGGGGCTGGACTCATCCTTTGCAGGGTGAGCCTCA
ATCACCACATCCTCCTTGAAGCTAAGGTCCACGTCTCGGGTGCCGACAAATTCGTAGAGTGCTCGCACTC
GGATGGCTGTGCTCTTTCGTCAGTAGAGACAATAATGGGTCCAAACATTATCGCAACTTACTGGTAGCGA
AATCAAACTCCTCCAGGTCATCTTCACCCTCGATTTGGACGTGCGGCTTCTCAATTTGCTCGTATCCATC
TTGCTCTTTCTCTTCTTCCTCCTCCTGAGGGGGCTCAAGCATGGATGTCTCGCCCACGCTGGCAGCCGGG
TGGGAGGCATCGGCAGCGAGACCAGCGTACCAGTCAATCGACTGACGGTTAGGGTTACCACTGACGAACG
AGTCCTCCGAAGGTGGGGCGGGGGAAGGAGCTCGTTCTTCCACAGGAGCAGGAGCAGCCTCGGGAGATGG
TGGCGCGTGCTCTCGGGGAGTTTCCTGGATGTGAGAAGGAGGCGCGGCGTCACCAATAACCTTGCCGACA
CCGGGAGGTCCAGATTTGTCAACGGTTTGAGCCTTTTTCAACCTGGCACCACCCTGAATAGCGGACAATA
ATGCACCCCTTCCTTGCTCGGGGTTTCCACCGCCAAGATTAGCAAGTGCCTTGGGGGGCTCCTTTGGTGC
TTGAGGAGCCGCGGAGCCTGGACGGGAAGTAGAAGGAGATGAACCACCCATAATGTTACCGAACAAAGCC
TGTGCCAGGCCTTGACGACCAGCACGAGAAGTAGTATACTCGTCGTCGGAAGAATCGGACTCGTCGACTT
GCTTCTCGGTGATATCCTCCCACTCGGGTTCGCTGGGAGGAGATCGGGTGGTTCGAGGAGGCTGNNNNNN
GTTTGAAGAAGGGATTGAAGCCGCCAGCAGGGGCGGCTGGAGAAGGAGTAGCACCAGGAGCACCACCGGG
CTTTCGGAAGGGGTTGTAAGAAGACCCAGACTCCGCGGGAGGCGCTGGGGGCGCGGGTGGGGCAGGTGGG
GCGGCAGGCGCAGGAGGTGCAGGGGAAGGAGCAGCAGGTGACCTAGCTTCCTCCTTGGGTGTCTCGGCCG
CAGGTGGAACCGGACTAGCCCCAAGACTCCTATTCTTTCTAACTGCGAGCAAAGCCTCTTCTTGTCTTCG
CTCCTCTTCCTCTTCCCTTTGCAGAGCTTCCAACCTCGCTCGACGCTCGGCTTTGGCTTTGGCAGCGGCT
TCTTCGCGACGTCGGAGCTCGAGCTCTTCAGGATCGTCTTCCTCGGGTTTGGGCGTAGGAGGCTGAGGGG
TGGGAGGAGTGGGAGCGGCAGGGGGGACGGGAGCTGTAGGGGCAGGAGGAGCAGGATGGGCACGAGAAGG
TGGAGGCACAGGTGCGGCCTTGCTGCGGGATGTGGGTGCAGGAGGAGGGGCGGCGGGCTTCTTCATGGCA
CTCTTCAAAGGAGGCGCAGGTTCAGTGGGCTTTTCCTCGCTCTTAGGCTCCGCAGCACCACCGCCAGCCT
CTGCCAATCTCCTCCTCCTAGCTTCATCTCTTTCCTTTTGCGCTTCTTCTGCCTTTCTACTCTTCTCTTC
GGCTTCTTGCTTCTCCTTCTCCAATCTGTCCTGCACGCTGGTATCAACTTCCTCCTCTTTATCCTCGGAG
GAAACACCTAGAGCTTTGAGACGCTCTTGGATACGTCGTTGAGCCTGCTCACGGATGTAAGCTTTTCGCT
CCTCAGGAGTCATACTCTTTGTAGAAGGGACGGAGGAAGAGGATGTTGGAGCTGGGGGAGGGGGAGGGGC
AGATGTGGAGGTAGCAGAGGCGGATGGGGGAGGAGGTGCAGGGGGTGGGGAGCGCGCGCCGGTAGGTGAT
CGAGGTCGCTCACGGTCATACCTGTCGCGGTCATCCCGCCTATCGCGATCATACTTGTCATACCTGTCAT
ACCTGTCACGAGACCTATCTCGCGATCTGTCTCGCCGGTCCCTGTCATAGTCATACCTATCCCTCTCCCG
ACTTCTGTCCCTCTCCCTATCATATGTCCCGCGGTATCTCTCATACTCATCCCTGTCTCTGTCTCGATCA
TCAAATCTCCCATGAGTCTTGTTTCTTTCGTCTCGTCTCCTTACACCGGCACGCTCCTCCATGGCCTTTT
CTTCCCTCCTCCTCTCCTGCCTCCGCTCAAGCTCGGGAAGCTTTTCGTGCATGAGATAAAGCAATTCTCT
TTCAAGCTTTCGGCGTTCCTCGTCCTTTTCAGCCGTACGACGACCCTTGGAAGTATACTCAATATCCTCT
TGGATACGCTTCACACGGTATTGCAAAGTCTCAATCTCCTCTTCAAGCTCTTCGTCCTCTGCAGATTTTT
CAGCAGACTTCTCGAGTAAGGAAGAGGTGTTCTCGAGCTTTCGTCGAATGTCTTTCAAGCCGGCATCGGG
ATCTTCGCCGGCATAACGCACAGACTTGCGGTCGAGGTGCCTGGAAGAGGGCTTGTATGTGGAAGGCACT
TCGTCAGAGTGCTTGTAAAGAAGAGCGTCCTTGGAAGCACTGGCAGGGGTCGAGTACGCAGGGGAGGCGG
TGCCCGGCCGAGAAGTAGACTCGTGTTTGAGAAGATCTTTCATGAAGTTGACCGTGGAGTCAATGTCTCG
CATAGAGGCAGGGACGAGCTCCTCGGGAAGCTTGTCAGGGATCTGGTTGCCATTAAGGGCTTTTTCGGGT
TAGCTTATGTACTTGTGTAGGGTAAATGCGAGACTCACCTCGGTAAATAAGACCCATCGCAACGTGGAAC
TCGGGCAAGTTGAGTTTGCCTCTGTTATCAACATCGGAGAGGTTCCTAGGTTGTTGTTAGACTTGATTCG
CTTCAAATCGCGCGAGAACCTACCAGATCTTCATGAGATCGTCTTGACTCAAACCGCTCTGACCAAAGAC
GTTCCTGGCCATCTCACCAGAAATGAATCCATCACCCTTGGTATCCCAAGCCCTGAAGATTTGGTCATAA
TCCTTCTTCTCTTGACGAGAGAGAGTCCACGGAATCTTGGGGGTATTGACAGAAGGATTTTGCAAAAGCG
ATTGGAAAGTCTGCTGCAGAGGCTGCGATGACTGAGCAAACTGGGGAACGCCCGAAGAAAATGGCTAGGA
AGGGTCAGCAGATGCGTATACGACGCGTCGAAAGTTCACTCACCTGGGACATATTGCTAGGCATGAAGCT
CTGCATCATAGTTTGCAGTCTTGGATCATGAGGCATACCAGTAGGTTGAGCCTGCAACCTGCCAACGCCG
GTGGGCTGCGACATCAAGCCAGCACCACCCTGCCAACCGGTCTGTTGCGGAGTCAATCCCATCCCTGTGG
GTTGAGACATCATTCCTGTTGGCTGAGACATCATACCCCCTTGAAATCCAGTCTGTTGAGGCATCATCCT
ACCAGCGTTCGCAGTAGCATTGAACCCAGTCTGTTGGGGCATCATTCCTGTCTGCTGGGATACCATGCCT
GCACCGCCCGGAAACCCGGTCATCTGCGGAGCAAGTCCATTCCCCCTGAAATTGCTCGAAGGAGGCTGAC
TGAGGAAGGCATAATTCTGGCCTGGTTGAGCTCCTACGATGCCTGTCTGTTGCGGACGCTGTTGCTGAGG
GAAGCCGGTCTGCATGGGCTGGAGACCAGCCCCAGGGAAGCCTGTTGGCTGGGAGTTGATGAATGAGGGT
TGCTGTTGCTGGCTGTAGGGGTATTGCCCCCACTGGTTCGACTGCA
Protein Sequence 
>gi|799336891|ref|XP_012051371.1| multidomain RhoGEF [Cryptococcus neoformans var. grubii H99]
MQSNQWGQYPYSQQQQPSFINSQPTGFPGAGLQPMQTGFPQQQRPQQTGIVGAQPGQNYAFLSQPPSSNF
RGNGLAPQMTGFPGGAGMVSQQTGMMPQQTGFNATANAGRMMPQQTGFQGGMMSQPTGMMSQPTGMGLTP
QQTGWQGGAGLMSQPTGVGRLQAQPTGMPHDPRLQTMMQSFMPSNMSQPFSSGVPQFAQSSQPLQQTFQS
LLQNPSVNTPKIPWTLSRQEKKDYDQIFRAWDTKGDGFISGEMARNVFGQSGLSQDDLMKIWNLSDVDNR
GKLNLPEFHVAMGLIYRALNGNQIPDKLPEELVPASMRDIDSTVNFMKDLLKHESTSRPGTASPAYSTPA
SASKDALLYKHSDEVPSTYKPSSRHLDRKSVRYAGEDPDAGLKDIRRKLENTSSLLEKSAEKSAEDEELE
EEIETLQYRVKRIQEDIEYTSKGRRTAEKDEERRKLERELLYLMHEKLPELERRQERRREEKAMEERAGV
RRRDERNKTHGRFDDRDRDRDEYERYRGTYDRERDRSRERDRYDYDRDRRDRSRDRSRDRYDRYDKYDRD
RRDDRDRYDRERPRSPTGARSPPPAPPPPSASATSTSAPPPPPAPTSSSSVPSTKSMTPEERKAYIREQA
QRRIQERLKALGVSSEDKEEEVDTSVQDRLEKEKQEAEEKSRKAEEAQKERDEARRRRLAEAGGGAAEPK
SEEKPTEPAPPLKSAMKKPAAPPPAPTSRSKAAPVPPPSRAHPAPPAPTAPVPPAAPTPPTPQPPTPKPE
EDDPEELELRRREEAAAKAKAERRARLEALQREEEEERRQEEALLAVRKNRSLGASPVPPAAETPKEEAR
SPAAPSPAPPAPAAPPAPPAPPAPPAESGEPEWEDITEKQVDESDSSDDEYTTSRAGRQGLAQALFGNIM
GGSSPSTSRPGSAAPQAPKEPPKALANLGGGNPEQGRGALLSAIQGGARLKKAQTVDKSGPPGVGKVIGD
AAPPSHIQETPREHAPPSPEAAPAPVEERAPSPAPPSEDSFVSGNPNRQSIDWYAGLAADASHPAASVGE
TSMLEPPQEEEEEKEQDGYEQIEKPHVQIEGEDDLEEFDFATTIRVRALYEFVGTRDVDLSFKEDVVIEA
HPAKDESSPWWYGTVVKDGSKGWFPKNYVEHIQAVHAKAIYSYAAGDPDQLPFAEGDILEVVDRSENDWW
KVENTGIIFLVPAAYLEVIDGVVSAHGARDGNLGVSPEPAAPTDTDAQPMSTIPEVTNAMEQLKLPAEGY
QGAEISDSLQPTEDSHRLSVHSIPPPLRSRPRAISTLSIASTAMSHTPSFITDNEEDEGESSSDDSILSF
WSSDESSSESEDVNEPEEEPPTDDRVADIEKPKKERRAAPKPPKKETDAEKEVERKKREEQRQAILAATG
LQLKREPSGAPAQRFGRVVSRRRPAPNVPGRKKRHAPAVPEGKSKKLPSLSSKELQSGRLETGDAYARYE
AFLAQSAQVQSKPLPRPEPVRAESRPSSQVLSPQLTGPAEGAALSSASTTTSLPTSTLSLGKETGGKITG
FFKSMMAPHGHEPKRPSISGPTITRVDEPPASPAPGSGIFTSSEEVDAGFGKTWSSLVEPSVLETMDKRE
RKRQEAIFEFIATEIGYNRDLQLIVEVFYASLLPLLDEKALTVIFANIEDILLFNTGFLSALEERQKAAR
LYIDRIGDVLSFLNEAGVYMTYCVNQHQAIKLLQSLREEKPELDAHLRHIQATNSSIRGLDLSHYLLIPM
QRITRYPLLIKQIIAYTPYDSSDLPPLQSVLHAVEGIVSRINESVREAEGQERLRVLSENLWIGGEGRLD
LTAPTAFLGPRKLIKEGPISKAKSGRKLSMVLCNDIIVLLEDKSLYRMPLALHEVEVRQTRDSTGFALKA
DQRRGGDTIALRAASASDAKDWMRKIDKARKRVLTTNRKTRARR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Disruption of the CIN1 gene had a pleiotropic effect on growth, normal cytokinesis, intracellular transports and the production of several virulence factors. Additionally, Cin1 interacts with cryptococcal Cdc42 and Wsp1 (a WASP homologue) proteins in vitro, suggesting a conserved role in the regulation of the actin cytoskeleton (Shen et al., 2010).
References
Shen et al., 2010: Shen G, Whittington A, Song K, Wang P. Pleiotropic function of intersectin homologue Cin1 in Cryptococcus neoformans. Molecular microbiology. 2010; 76(3); 662-676. [PubMed: 20345666].