Victors

CHS3
Victor ID	5287
Gene Name	CHS3
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23889683
NCBI Protein GI	799346398
Locus Tag	CNAG_06487
Genbank Accession	CP003832
Protein Accession	XP_012053352
Taxonomy ID	235443
Chromosome No	13
Gene Starting Position	645024
Gene Ending Position	649237
Gene Strand (Orientation)	+
Protein pI	8.46
Protein Weight	98765.69
Protein Length	944
DNA Sequence	>gi\|799350950:645024-649237 Cryptococcus neoformans var. grubii H99 chromosome 13, complete sequence TCGACTCATACTCATACTTCATTCATCCATATACCCACCACATCGCCCATGCCAAACATATCACGCAAAC CTCCTCCGCGCTTCTACTCTCCTTCTCACTCCCCTTCGCCTTCACTTTATGCTCCCATACAATCACCCCC GGCCCCCTCTTATGACTACCACGCCAACCCCAGGACGTTGAATCCATTCTCCGACGCACGTGAAGTCGGT GGATATGCTCAACTCCAAGGGGAAGATCAAATGACTGGCGCACCTTTATACCAGCCTCCGTATGCTCCTC AACTACTCGTTGCTCAACCAACTCCTGTTTCTTCCCGCCTCCCGTTTTTCGAAGCTGCGCTTGCCCGCGC GCGCGGTATCCAAACGCCCAGCTTACCAGAAGCCCCGACTCCAGCTTATGCCCAACCTTTACCTTCCTAC CTCCCGCCTCCCGACCCCAATCACCCTGATCTATCTGTTGGTTTGACTCAGGCCAATACAGTTCGCTACG CCATCAATCCAAGATCTCAGTTGAAGGAAGGATCCCGTTCGCCTTCACCGTTCATGGATGACAGTTTCGT TTACAATGATGCTGCTCACCTCTATAACGTTGAGCCGGACGTCGAAAAAGCTTTGCTCGGAAGTGGACTG GGTTATGAATCGGAGAAGCGTGTCGAATCTTCGATGGGCTTCAATGACAATGATGGCGACCTCTCAGTCC CTCAGTCGTTTGGTGGCCGACCTCCTTCATGGGAGCCGAGCGGCATATTGGATGAAAAAGGGGAAATGTC GACTACAAAGCATTTTGGGCCTGCACCTGCGGGTCGAGTCGGTCGGCGAGCGCACAACGCTGCAGGGTAC CGCAGGATCAAACAATCAGCGACCCTCGATGAGAATGGTTTCTTTGCTATCGAGATGAACATCCCCACCC GACTGGCGCAATTTCTACCCATCAAGGGAGTTGAAGAGCAAAAGACTACAAGGTAGGGCAGCGACTTTTG CAAGCTTGAGACCCCGTCTATTCGCTGACTCACACATAGGTATACTGCGATTACCACCGACCCAGATGAT GTCCCAGCAGCTGGCTTCCGTCTTCGCCAGAACATGACTTCTCCGCCCCGACAGACTGAACTTTTTATCG TGATCACTATGTACAATGAGAACGCCGAGCTCTTTTGTCGAACACTTTATGGTGTCATGAAGAATATAGC CCACCTATGTGGGCGTAAGAACTCAAGGGTCTGGGGCAAGGATGGTTGGCAAAAGGTGGGTGATCTTATA TCTCCGCATATGTGTTTCAATATTGATGTCAAGGTATTCAGGTTGTCGTTTGCATTGTCGCGGACGGACG TAAGGCGGTTAACCCCCGCGTCCTCGATTGTTTAGCAGCTCTTGGAGTTTACCAAGAAGGTCAGGTTATC TTCAACAGTACAAAGCGCATTGCTGACATTTCGATACTTTGACAAATAGGCGCAATGACGAACACAGTAA AGGATCGACCGGTCACAGCGCATGTTTTCGAATACACGACCAGCTTTGCTCTTGACGGTGATTTACACTT CAAATATCCAGACAAAGGCATTGTCCCCTGCCAGATTATCTTCTGCATGAAAGAGAAAAATGTGAGCTTG GGGCTCCATCATGTATGCGTCATGTATTCGTAGCTGATTACTTCTTCTTTAGGCCAAAAAGATCAACTCC CATCGATGGTTTTTCAACGCCTTCGCGCCCTTGCTATCAGTATGTATCACTCATTCGTTCGACCCAATGA ACGCATCACTGACCATGTATGTAGCCAAATGTCTGCATTCTTCTTGATGTGGGAACCCAGCCAGCTCCGA AATCCATCTATCATCTTTGGAAAGCATTTGATGTCAATTCTAATGTTGGTGGTGCCTGTGGAGAAATTGC GACCTTCAAGGGCAAAACTTGGAGGAGTTTATTGAACCCCCTTGGTAAGTCAGCAACCGCCGCACTAATA TTCTACATGGTCAGCTAAACGCTGGTTTGTTGCCTACTAGTCGCGGCCCAAGCCTTTGAGTACAAGATGT GAGTACAACATGCAAATTTATTTGTGTCGAATCTGACGCTGATAATGACCATAGGTCCAACATCCTCGAC AAACCTTTGGAGAGTCTCTTCGGATACTGCACTGTGTTGCCTGGTGCCTTCTCGGCTTACAGGGTGAGTT GCAACAGCTGAGCATCTTTAGTTTCCAGGACTCACAGCAGACGGTGATATGCAGTGGATCGCTTTGCAAA ACAATGGGGATGGGAGAACGGGACCTTTGGCGAGTTATTTTGCTGGTGAACAGCTCAATACTGGAAAGGC AGACACATTCACTGGTAATATGTGAGTCAAAAATTGTAGAACTCAAGCGTTTTACTGACTGCCTCGTTCT TCATCAGGGTATGTTTCATAGCGGCGCTTGATGTTTCTTTTTGATTATCTTCTAATCAGCTGCTATAGTA CCTGGCAGAAGATAGAATCCTGTGTTTCGAAATCGTGTAGGCACCACTTCACGGTAATAATACATGTCAT TGTTGCTGATCCAACACGGCGTATAGGGCCAAACCCAAGGCCAACTGGGTGCTGAAATTCGTTAAGGCTG CTGTTGGAGAAACAGATTGCCCTGATACCATCCCAGAGTTTATTGCTCAAAGAAGAAGGTGAGTAATTCT TTTTATCGGGGAAAAAAGAAAAAGGGGGGGTATCTGACATTCTTCGTCTTCTAGATGGCTTAACGGTTCC TTCTTTGCAGCTGTGAGCGCCGCACGGATTTGGCATTGAGTTTCACGCTTACATATCTTCAGGTCTATGC GTTGATGCACACGAACCAAATTTGGCGATCCGACCATTCGTTCGCGAGAAAGTCAGCCCTGATGTTGGAA TCAGTGTACAACTTTCTGAACCTGATATTCTCGTGGTTCGCTTTGGCAAACTTTTACATTTTCTTTGTGG GTACAGCCACTGTTGTATGTTTATACGGATACCCTAATAAGCAAAAAAAAAAAAAAAAAAAAAACAGGTC ATCCTTACGAGCGCTTTGGAGGGCAGCGCTTTCAATGTCCCTCATATCGATGTGCTCAATACTATTGCAC GAGTACGCTGTTTTCATCCGTATAAGACATTAGCTCATTCGATGTTAGTATGGTTACCTTGGTGCTTTGG TTGGTTGTTTCATCTTCGCAATGGGAAACAGGCCACAAGGGTATGTGTTCATTTCTCTGGACAAGAGGGA CAGCCAGCCGACGCTTTTCATCTTTCTTCAGTTCGCCTTGGAAGTATAAAGCAGCAATCTACTTTTTCGC CCTTTTGACTACCTAGTGAGTCGTCACAAGTGGTGCTCAGGGGTCAAGGATAATCACTAAACGTTTTTTA ACACAGTATGCTGGTCGCAGCAGTGCTTTGTACGGTACAGGCAATCAAAAATATAAACAGCCCAATTTTT GCCAAGATGGTAGTATCACTCATATCAACCTATGGTATTTATGTGATTTCCAGTTTCTTGGCCCTTGACC CTTGGTAAACTGGTCCCCTTCATCTCTTAAAGCTTCTCTGTGACTGACAATCTATAGGCACATCTTTACT TGCTTTATTCAATATGTTCTCTTCTCACCTAGTAAGTTTGATGAACCTTTTGTGAGATAGTTACTGATCT ACTTCTCCTGAAGCTTATATCAATGTTGTGAGTCCTCTTTGCTCATTTAGGTATGCGTTACCATGTATTA ATAAAATACTCTGCAGCTTAATGTTGTAAGTGTTGGGGTTGTTATTCTGAAAATGAACTATCGGCTAACC TATACAATCAGTATGCCTATTCCAACCTGTAAGTCAAGGTACAACTCTTCCTATTCTTCGCAGCTACTGA CTGCATCATATAGTCACGACTTGTCATGGGGTACAAAAGGCTCTGATGCAACCCAGGCGTCGGATTTGGG TGCTGTTTCCGGAGTGGGAAAGCACGTCGAAGTGGAACTTGTAACTGCCCAGCAAGACATTGATATTGCC TATCAGGATGCTTTGGACAATATTAGATTAAGAGGATCAAAAGTTGACTCTGCTGAATCTGAGCCCAAAA AGGAGCAATCTGAACAAGCCCAGAAGGATACTTATGTGAGTGCTTTTGCTATCAACTTGTGAGTAGCAGC TAATGTGTTGCAGGCCAACTTTCGTACCAATGTAAGCATTGCCATCATGCTAGTACAAAAGAAAAGGGAT GACGCCAAATCATA
Protein Sequence	>gi\|799346398\|ref\|XP_012053352.1\| chitin synthase [Cryptococcus neoformans var. grubii H99] MPNISRKPPPRFYSPSHSPSPSLYAPIQSPPAPSYDYHANPRTLNPFSDAREVGGYAQLQGEDQMTGAPL YQPPYAPQLLVAQPTPVSSRLPFFEAALARARGIQTPSLPEAPTPAYAQPLPSYLPPPDPNHPDLSVGLT QANTVRYAINPRSQLKEGSRSPSPFMDDSFVYNDAAHLYNVEPDVEKALLGSGLGYESEKRVESSMGFND NDGDLSVPQSFGGRPPSWEPSGILDEKGEMSTTKHFGPAPAGRVGRRAHNAAGYRRIKQSATLDENGFFA IEMNIPTRLAQFLPIKGVEEQKTTRYTAITTDPDDVPAAGFRLRQNMTSPPRQTELFIVITMYNENAELF CRTLYGVMKNIAHLCGRKNSRVWGKDGWQKVVVCIVADGRKAVNPRVLDCLAALGVYQEGAMTNTVKDRP VTAHVFEYTTSFALDGDLHFKYPDKGIVPCQIIFCMKEKNAKKINSHRWFFNAFAPLLSPNVCILLDVGT QPAPKSIYHLWKAFDVNSNVGGACGEIATFKGKTWRSLLNPLVAAQAFEYKMSNILDKPLESLFGYCTVL PGAFSAYRWIALQNNGDGRTGPLASYFAGEQLNTGKADTFTGNITWQKIESCVSKSAKPKANWVLKFVKA AVGETDCPDTIPEFIAQRRRWLNGSFFAAVYALMHTNQIWRSDHSFARKSALMLESVYNFLNLIFSWFAL ANFYIFFVILTSALEGSAFNVPHIDVLNTIARYGYLGALVGCFIFAMGNRPQGSPWKYKAAIYFFALLTT YMLVAAVLCTVQAIKNINSPIFAKMVVSLISTYGIYVISSFLALDPWHIFTCFIQYVLFSPITDLLLLKL ISMFHDLSWGTKGSDATQASDLGAVSGVGKHVEVELVTAQQDIDIAYQDALDNIRLRGSKVDSAESEPKK EQSEQAQKDTYANFRTNVSIAIMLVQKKRDDAKS
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: One of the genes involved in melanization of Cryptococcus neoformans (Walton et al., 2005).
References	*Walton et al., 2005:* Walton FJ, Idnurm A, Heitman J. Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans. Molecular microbiology. 2005; 57(5); 1381-1396. [PubMed: 16102007 ].


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CHS3