Victors

CFT2
Victor ID	5285
Gene Name	CFT2
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23886502
NCBI Protein GI	799320449
Locus Tag	CNAG_02959
Genbank Accession	CP003822
Protein Accession	XP_012047832
Taxonomy ID	235443
Chromosome No	3
Gene Starting Position	335472
Gene Ending Position	339487
Gene Strand (Orientation)	-
Protein pI	5.33
Protein Weight	44852.87
Protein Length	437
DNA Sequence	>gi\|799350639:335472-339487 Cryptococcus neoformans var. grubii H99 chromosome 3, complete sequence TTTTCCGTACGTATTGCATGGTATATCTATTAACGTATATCGCTCAGGCCAGGACAATAGTGAGCCGTGT CAAAACAAGTACCCTTCCATTTCTTTTGCTAATCGTTGACAAGCCTCGCTATCGATTGTGAAATGGTTGG TATCGGCCCCAACGGCATGGAAAATACCCTCGCCCGAGTATCCATTGTTAATTATCACGGCGCGGTCATT CTGGATACTTTTGTGCAACCCCGTGAACCAGTTACCGATTACCGTACATGGATCTCTGGAGTCAAGCAAT CAGATTTGTTGGGAGCACCCCAGTTTGAAGAGGTACATAAGCAGGTGGCAGATTTGCTTCATGATAAGAT CTTGATTGGGCACGCTATAGATAATGATCTGAAGGTATGTATGCTTGCTAGGGAAAGAAGCGAAAAGCTG ATCAACAGAAAACAGGTCTTGATGTTGACTCACCCTGGGCCCCTCACTAGAGACACTCAAAGATATAAGC CCCTGCAAGAGATTGCCAAAAATAAGAGACCAGGCTTGAAGAAACTGTCAGAATTACTGCTTGGAATTCA GATTCAGACCGGAGCCCATAGTTCTGTAAGCCATTTCCATTGCGCCTATTCTATAGCCCCTTACCTCCCC TCCCACTAGCTTGTTGATGCACGAGTGACCATGGCCCTATACCGACTTCATAAAAAAGAATGGGAGCGGT CTGTCTGGCGTCAAACAGAAGCATACCGGAGTACTTCTTCCGTCAACAAACTTAAGCATGTCCTGGGAAA GCGTGGGCATGATGAAAAAGAAGTTGAGGATGGAGAAGAAACTGGGGGAGAAAGCAAAAGCAAGAATAGG AAGAAGAGAGATATTGGCGGTGGCCCCCAACAATTCCCTGGTGGTGGGAGAAAAGGGATCAGTAGCGGTT TAGATGTCATTGTGAGGAGAAATGGGCAAAGAGTGGATGGGAATGGGAGAGGGGACGGAAGCAGTCGCAG AAAGGCTGGCAGGGATGAAATGTCGACTGTTGCTGGAGGCGAAAATTGGTGGGAGCAGCCAGCGGCATGA TCTGGATTTGTCCAGTGGGATTAGAACCCCTATGTATTACCACTGATATTGTTGTAATAAACATTACGGC AGGAATCTGCTTTAAGGTCAGTCCCGGGCCCCTAAAAGGGGCATTATGACCATAAAGGAAGTTGGAAGAT AGGGAAATGATCTGCTTATGGCTGCATACGATCAATAATCAACCAATATAATACCGAAACCATATCTGTA CGAAACACATTACGAAAGCAATGTAGCATGACTCCCAAATTAAAGACTATTCTTAGTCATGGGAATGAGA GCGTCCTCGGGATCCTTATTCTTATTGAGATGAGCTGTGTTGCGGGCGGTGCCCTCCTCAGAAGCGTCTT CGTCCTTCTCAGATCCTTCTGAAGCTTGGCCCTCGGCCGCCTGGGCGTCGGCCGCCCTCTTAATTTCAGC CCTTGCTTGGATACGGCCATGGGCTTTAGAGCCTCCACCAAAGATTGTAAGACGGCCTTCGTACCACTTC ATGATAGCCAAACCAATAATGACCGCAATCCAATAGAAACAGTAAGAGAGGATAGATCCGAGAGAAGCGG TGTTATTCCAACCTTAGCATGGGGAAAGATCAATGCTGAACCCGATATTAACAAATTATTTTGGATAACT TACCCAAAATGGCGTTGAAAACCTGCCAACCACCGTTGGTGCCGACAGCTCCGGGCTCAGGATTTCCGTA CTCAAGATGCCAGCTACGGTGATATCTGTCAATGATAGGCTCTAATGGAATATTTAAGCATGCTTACACG TTACCAGCAACTTGGAATGAACCAGGGCCGTTACCAGACTCAGCAACATCACCACCAACAGCAGAAGAGA ATCGCTAATGGGAAGGATGAGCAACGAGAAATTATAGATGTATGCGGACACTTACGTAGTATTCAAAATC GTAAACACCTTTCTGCATGGCAAAGACACCCTCTTGGTTAGTCCTGATTGTCAAGGGCGAGAATGCAGCA GACACCTACGCTGAACAATCCCGAACCGATGAGGAACAAGAAGCAAGTAGAAACAATCAAGAACCAGTGA AGAGCAAGAGTAGAGCCAGTGCGGTAGATACACCATCCTGATCGGATAGATGAGCCGAGTAGCCATGACA TGATGAACATATTTAGCTTACCAACGAAGATACCGGCGATGAGGCCGACAATCGCAGCAATGGGGATAGA GGCACCATCTTGGCCTAAAGCAACCTGCGGAACAGTGTCAGTGGCAGACGTTCTCAACACACCAAAGCAA GATAATGGGAAGGGGAGGGCCTCAACTTACACCACCAACGAAGACAATAGCTTCCAAACCCTCTCGCACG ACAGTGATGAAAGGCAGGAAGAAGATGGCATACTTTCCACTTCGAGCCTTCTTCTTCATGGCTTGCTCTT CGGCGAGCTCCTCCTGGGTGAGTGCCCTGTCAGGCTCGCCATCTTCCTTGTTACCGCCGAAACTGAAGAG GGCCTTGCCGGCACGATGAGCGAAAGCTTCGGAAAGCTTGATACGCCATTTAACTCGAGATTGGTCCATC TTCAAAAAGGTGAGACCCATGACATAGATGATGATGCAAGCTATGGAACCAGACCCGTTATCAGTTATGC GAAGAGGAGATTGACGCAACTACGTACCGATAAGACTGAAAATACCCTCCCATAATTCTTCTGTATTGGA CCACAAGTCGGTCAAAGTCTATTAAGTCGCAAAATATTAGCCAGCGAGCCCTTAGAGATCCCACCAATTA GATGCACTTACAGTATACCACTACAGCACGAGAACCAAGATGGAACATATTAACGGCATACTTCTAGAAA CAAGGATAGTTTTTTCCTGGACTTACGACTATTACGATGGTCAACGTCAGCGCAGTTGGATCTTTCGCCA AATAAATAGTGACTCACCAGCAATGAAAGCAGCGCCGACAGCAACGGCAATGACGAAACCGGTCAAAGTA CCCGCCCAAATCTACACAACTGTCTCAGGATTTGTCACTTGGAAGAATAGTTGGAATAATACACTCACTT GGATACGCATTCGCCGAAGAATTCGTTTCGTTTTCTTTATTTCCTCCTCCTCTGAAAGCTGGTCAACTTG GGCATCACCATTTCTGAGGCCTCCAGAAGTCATAAGCTGTTCCACGAAGGACAGCAAAACCCTTTACGCA AGAACGTTGCTCAGTCAGCGCGTTCCCTGAGGACCAGACCTGAAGAGAAGACTTACGAAACGATGATGGC CGCTTCGACCGTCTCACGGAAGACTATGAAGAAGATGGTGACCGAGAATAGGTCCTTCGCCATAATGGAA GTTTGGCCGTAGAGTTAATAGGCAAAGAACACTGAATGAAAGTCACAGACTTTTGAGGTGATAAAAAAGT AAGCTGATGGTCCAGGATACTATTATTTAGTACGCATTATGCCCTCTTTTATTTTTGTCGGCTCTTTCTA CCCGAAAAATCACCAACTTTTTGTAATAGGCCGATCTGATTACGGGTCGCTGCTGCGAAGGACATCCTCC CGTGTTCTATGTTCCATATCCCGTCATTCCACCATCGAAACGGTCACAATAACGACAGGAAGAAAACAGG ATCGGGCAATTCGGACGAAGTTGAAAAGATGGAAAGAGACTGTGTCCTGTAGACAGGCACCCTTTTCACA AGCCTTATTGGTCAGATTCTGCGAGTTTTATTTGCGCTACTATAGGCTGTCGGCCGTCGAACTGGGAAGA CACTAGTTAAGAGTCGAGATAAGACAAAAATGATAACAGGGACTCTACTCTATTTTGGGCTTACCATGTT TCTTGTGGCTTGAAGCAGCTGCAGCAGTTCCTGCAAAGTGAAGAGCGTTGTACAGCCAGCAATTGATCGT AATGGTACACGCAGTATGACACCTGAATCTAGGTTCGTTAGTTAGGGGAAGTCAATGTCTTCGGCTGTAG AAAGAATGCACTGACCATCAAGCTGT
Protein Sequence	>gi\|799320449\|ref\|XP_012047832.1\| high-affinity iron transporter [Cryptococcus neoformans var. grubii H99] MAKDLFSVTIFFIVFRETVEAAIIVSVLLSFVEQLMTSGGLRNGDAQVDQLSEEEEIKKTKRILRRMRIQ IWAGTLTGFVIAVAVGAAFIAVWYTTLTDLWSNTEELWEGIFSLIACIIIYVMGLTFLKMDQSRVKWRIK LSEAFAHRAGKALFSFGGNKEDGEPDRALTQEELAEEQAMKKKARSGKYAIFFLPFITVVREGLEAIVFV GGVALGQDGASIPIAAIVGLIAGIFVGWCIYRTGSTLALHWFLIVSTCFLFLIGSGLFSKGVYDFEYYRF SSAVGGDVAESGNGPGSFQVAGNVWHLEYGNPEPGAVGTNGGWQVFNAILGWNNTASLGSILSYCFYWIA VIIGLAIMKWYEGRLTIFGGGSKAHGRIQARAEIKRAADAQAAEGQASEGSEKDEDASEEGTARNTAHLN KNKDPEDALIPMTKNSL
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: CFT2 played no apparent role in iron acquisition;cft2 mutant was attenuated for virulence (Jung et al., 2008).
References	*Jung et al., 2008:* Jung WH, Sham A, Lian T, Singh A, Kosman DJ, Kronstad JW. Iron source preference and regulation of iron uptake in Cryptococcus neoformans. PLoS pathogens. 2008; 4(2); e45. [PubMed: 18282105].


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CFT2