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CDC43

Victor ID 5284
Gene Name CDC43
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886315
NCBI Protein GI 799321549
Locus Tag CNAG_02756
Genbank Accession CP003822
Protein Accession XP_012048111
Taxonomy ID 235443
Chromosome No 3
Gene Starting Position 835625
Gene Ending Position 837219
Gene Strand (Orientation) -
Protein pI 4.68
Protein Weight 31575.13
Protein Length 294
DNA Sequence 
>gi|799350639:835625-837219 Cryptococcus neoformans var. grubii H99 chromosome 3, complete sequence
ATGTGGAAGTGTTGTAATGGTGAATATACATGGATAAACATTGTTGGTATGCTAGGTATAAATGCAAATG
TTGTTATCATTATCATAATCATTCTTGTTCCTTGACCCTGGTGATCTCTCTTTGCAGCCATTCTGCAGTT
TCAGCGCTGACATTCCACCTCACATCCAGTGTTTTCAAACCAAAACTGTTTTCTTTGTCGTCGCCGAAGC
GATTCAGTGATAATGAAAGTGCAGCAAGAGCAAGATAAGAGTGATAAGGATCAGGATAGTCCTCTGGCTC
CTTTCCAAAGCCGCCCAAAGGTGACTGTGCCGATAGAAGAAACGCCTTATTGGCATCGTGATCAATCAGA
TCGTCTCGGCCCAAAACCTTTCCAGGCGTCAGCTGGACATTTGTTTATATGACATAAAGTATGTGAAACG
CTTACAGAAAGAGTTCCTCCACACCAGAATGAATAACAAACATCCTCGAGCTTGCCTGGTCGCCCTTGGA
AGCCTCCTAGCTGTCTAGAGACTAGCCACCGCAAGGTATCAGTTTGAAAGATTCGGTCGTTCAAAGGTGA
CGGAGAGTTATCAAAGTCAGACATGAAGGAAAGGGTTGTCAGAGAGCAATAGGTTGTCCCGCCTAAAAGT
ATATTGAGACGCAGTTCAGTAATGGAATTTTGACCTACCTTGGGCCTCAATCACTCCAGGTCTGGAAGCA
TAGCCGCCCTCCCAGGTCTTTTACTCCGTCAGCGGCTGTGTAGTATCCCGACAATTGATACTCACTCTGC
ACTTTCGTATCCACTCCTTCAGTTTAGATAGATTCATACCCGAAGAGTCCTGTATTATGTGGGATATAAC
ACTTGCTATGTAGGCCATGCGAGCGTCAGACTGAAAGCCTTCCAAAAGGTATGGTTCGGCAGGAAGAGGC
GAGAACCTTTACGCGTACGTCAATTCTCTCACTAACTCCACAGATTAAGCAGCACGTACGATCCATCTTC
CGCTTGACATGAATTTAGAAAGTATAACAGTCCTGGAATGTTCAGCCGATCTAATGGTGCTCTGAGAAGA
GCTAGACACAAAAGGGCAGTATAAGTTGAAGGGAGATGGGGGGGCGATGTGGTGGGGTTCTGATGGTTTC
CAGTCAGCCATGCAAGCCATCAGAGAGCATGCATCTCACTGGTGTGTCCATGTATGTGGACCCCTTGAAC
CCTCCGGACGCTGTTTGTATGATAACAGATGTCAGTCGTGACACTTCTCGCTGTGAAGGGACCAACTTGC
GAACTTGTAGAGACCATATCCATTCCGCCCATTCTGCACGCTGTTTTTCTGTTGTCTTCTCTCGCAAAAC
ACCCAAGACGTCAAGGGCACATAAGCAAAAGTAGGCGATGGTCACACTTGTATAGGCCGACGTCAGTTGC
TGCGGGTATTACAGTCCATGGCGTTCGCGTACCGATTTGAATCGTGTCCTTCGGCAGCTGTAGGAAGGGC
CGTGAGGCAGCGCACAAAGTAGTTGACATGTGCATTGCGCTTGAAGGTGGCCTGGTGTGGGTGCATGGTG
AAAGCTCGCTGTCGCTGCCGTTGTTGTCGTCGCTACCGTTGTGGTCGTTGTTGCC
Protein Sequence 
>gi|799321549|ref|XP_012048111.1| geranylgeranyl transferase type-1 subunit beta, variant [Cryptococcus neoformans var. grubii H99]
MGGMDMVSTTSGGFKGSTYMDTPNPTTSPPHLPSTYTALLCLALLRAPLDRLNIPGLLYFLNSCQAEDGS
FSPLPAEPYLLEGFQSDARMAYIASVISHIIQDSSGMNLSKLKEWIRKCRTWEGGYASRPGVIEAQGGTT
YCSLTTLSFMSDFDNSPSPLNDRIFQTDTLRWLVSRQLGGFQGRPGKLEDVCYSFWCGGTLSVLGRDDLI
DHDANKAFLLSAQSPLGGFGKEPEDYPDPYHSYLALAALSLSLNRFGDDKENSFGLKTLDVRWNVSAETA
EWLQREITRVKEQE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Cryptococcus neoformans CDC43 is important for thermotolerance, morphogenesis, and virulence (Selvig et al., 2013).
References
Selvig et al., 2013: Selvig K, Ballou ER, Nichols CB, Alspaugh JA. Restricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence. Eukaryotic cell. 2013; 12(11); 1462-1471. [PubMed: 24014765 ].