Victors

CDC24
Victor ID	5283
Gene Name	CDC24
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23887681
NCBI Protein GI	799338496
Locus Tag	CNAG_04243
Genbank Accession	CP003828
Protein Accession	XP_012051688
Taxonomy ID	235443
Chromosome No	9
Gene Starting Position	383435
Gene Ending Position	388823
Gene Strand (Orientation)	+
Protein pI	6.73
Protein Weight	118541.92
Protein Length	1112
DNA Sequence	>gi\|799350821:383435-388823 Cryptococcus neoformans var. grubii H99 chromosome 9, complete sequence TGTCTTCGGAGGTGAACACACCTTATTGTCTTTTCACGCGTCCAGCTTTTTTCCTTCGCTTGCTTGTTGT CGCTATCTTCAGTCGGTCAATAATTTGAATCCTTCTTCCATTCTCGATATCCTAATACCTAGCGAGCTTC AGCAATATTAAGCTATAGACTATAAGCTCGTCCTCGTTTCGAGAACGGCGGCGACAAACTTCAAAGTCAT TACGGTATTTCAGCCAGACAAGGCATTTTTGGTTACCGAAATTGCTGGCTGTCGCCACGGACGCGTTCCC CACATACATTTGGATACCTACATTCTCCCAAAATTCCCATACTAAAACCATTACCTCCTACATCAACGTC CTCAACCTCTCAAGGTTTTTTGCCCTATCTTTCTTCTCCAACGACATTTCTGCCACAGCGTCTGCGAACG AGAAGGACAAAAGGCGAAGACGGAAAGGACATTGTGGAACGGACATTTGCAAGGGAAAGGCGTTTCAAGA AAGACGCTCGGACGCCGGATTATTTGAGCTCGCGTCGGTGTCTCTGGCGGATTGCTGTGGAGATATTGCA GCGAAGGTCTGAGAGAAGCTGGTGGATTGGAGTACATCCAGATACAGCTCTTGTTGCCTGCACTCAGAAG AAGGAATTGGAGGAGAAAGACGGTATCGACGATCCACTGGCCATCGCCCACGTCCATCAATCTCCTAGCA CACACAGTAGCGGTCCGTCGCGACCTGAACTCTTCGGGCTGCACTCCAAACTGCAGACGGTCGGTGCTCT TACTCCCACGAGCCACGACAAGGTCCAAGCTACGGTCCACTGTTCTTCACTTGTTACCGAAGCGACTTAT CCAAGCGACGGGCGACACCACCTTCGGGTTTCGACGCCCTCTCTTGTCTTGCTTGTAGCGGTACTTGTCA CCAACAGTCATTCAACCAACCTGATAACGGTCATCCTTTGACTTTTGACAGCTGCGCCCTGCATTTCGAC TATCGCTTTCTATTCCAGTTCGATAATCGCTCCATATTCCAGCCACCAATTGACTCGTTTGCCTTTGCCC GGCCTTGATATACCTTTATATTGCCATCATCCTTCCTAAAAGGCCTCAATTCGAGTCCCATCCTGCAAAG GCGATCGTCGTCCTCGAAAACTGGTCTGGCCATCTCTACACAGGACCTTCCTTTGTAGCTTTCCTCGACC ATTCACCATCGCTCGCTACCTTGACCTCCCACTATACAAACGCAACAACATCTTTCTTCATTAGCTTGCT GCTAGATTGAACTGCGACATCTTCGAATCCCCTCTATATTACCAACTCGGTATATTTGGCCAGTGCTTTC TTGACCAGGTGATCCAGGCAAGTCAAGCACGGCCCGTAAACTCATCACAATCATCCCATACATCAGCCTA GCTTTCCGATGTCTGTATCCGGTCCCATCTCCAGGAGACGTATAGGCTCTGTGAGTCAAAGAGGAAATGA AAGTTTACCGCAGCTGGACATTCAGAGTATTCAAATGCCGTCAAATCCGTAAGCACTTGCCCTATTATTG CAGAATTGTAGCTGATAACACATCAATGACTCAGCCAAAACGCCCTTGCTCTCAAAACAGCGGCGCTGTC AACTTCTACTAGGTCTCTACACCAAATTTGCTCCATTTTGAAAAAGAGATTATTATGTGTGGATGGTTTT AAGGCATTTTTAGGTGCGTCATGCGATGTGGCCTGCGCGTTGATGGCAAACAAGCTGATCAATGTTACGC GCTACCGTAGAACAACCACCTAATGCCGAACCATTGGATGTCGTTTCACATATGTGTCATCTTTTCCGGC TTGGTTCACCTCTTTGTCACCTTTACAACCTCCTTATCCCATCCTTCGTCGATTGTTTATCACCGCTATA TGCCGACTTGCCAGCACCTGCCAAAATCGAATATGACTTTCCTCAATTCTACGACTCTCCTAATGGTGTC CGCAATTGGGCCAAGCGACCAGAAAATGCCAAACCCTGTCAAAGATATATAGCAGCCTTTTGTATGGCGA TGAAGAAGCGAATAGAGGAAGGAAGATGGACATCTGATATGTGGGCGTTGCATGAGCTGTGGGGCAAGTC GACTGGGGAGGACATCGAAGCGTACGACTCAACGGGTTTGATGAAGGTGTTGAGCACGGTAGAGGAAATG CTGGACAATCTGCCAGAATCCGCCATGTCTCCTATATCACCTCAAACTCCTTTCACAGCATCGGGTTCCA TTGCTCAGCGTGCACAGTCTAGACAATCTTACGACTTACCATTTTCCATGGGTGGAATAGGCTCGGGTGC GAGTGCGGTGGCTAATATGGCGGCGACCATGAACGGTGGGGTGCATGTCGAAACTGGTCCAAGTGAGAAC TCTCCAACTGCAGCGGAGATGCAACGCGGCCTGTCAACATCATTGGCTGAAGCCAACGCCTTCAAATCAG TCGAGGAGTTGGTTGCGAGTGAGAAAAGTTATGTGCAGGAGCTGGAAATTCTGGTGAGATGTTCACAAGA AATGCTGGAGGCCCAGTTGGTGTCCACCGAAACGAATCATCAGATTTTCTCAAATCTATCAAAGATTTTA GATTTCCACGTGAGCAAACGTTTGGATAAAGCACATATGCAATAATGCTAACCCACTTTCGAAGCGTAAA TTCTTAATCAAACTTGAGACGGAGTATGAGCCTATTCAAGAGCGAGGACCCGGCGCTTGGGCAGAGGGTG TATGGGGCAGACCGTTCATTTTGAGCGAGGCGGAGTTTGACTGCTACGGCCCATACTGTGCCAATTACCT CGACGCGATCACTGTGGTGAATGAGCAGATGCCAATACTTATGGTGAGCGGAGCCCTGCAGGTTATTGGT GACTCAAATTGACTATTTCCGCAGCGAGGACAAGAGTTATCACCGGGAGAAAGGCCGTGCTTGGACCCCC AACGGGAACTGCAGGCGTTCATGATCAAGCCTATCCAGAGAATCACCAAATATGGTCTTCTTCTTGACGT ATGTCATTATGCGCAGGTGAATGAATAAAACTGCTAACAGTGACATTCAGGCTATTCTCCACGCCACAGC CAAGCATGAGTATCCGTTCCGACCAGAATTGGAAGAGGCTTCTGCTGCGGTCAAGCGTATTGCCGCCGGC ATCAACGAAGTTACAGACTTCAAGGCCAAGCAAGCCACTGTGCGCGAACTTATCGAACGGGTTGATGATT GGAAAGGTCACGACGTAGACAAGTTCGGACCGTTACATATCGACGACCACTTCACGGTGACCAAGGCTGA TCAGCCACGAGAATACCACGTTTTCTTGTTTGAAAAGATGATGCTCTGTTGCAAAGAGATCACACCAGAA AAGAAGAAGCAGAACAAGAATTCGAGCATGTTAAGGAAAGATCGAGGAACCAGCAAGAGTGGACCGCTTG ACAAGAAGAAACTGGCATTGAAGGGTAGAATATTTGTCTCAAACATTAAGGAAGCCACCATATTGCCCAC TGAGCCCGGAGGTGAGTTAAATTGTTGGTTTCAAATGACCATAACTAACCATATTATCAAGATGCATATG GCGTCGCTCGATTATTGATCGGATGGACTATTCCTCTTCGAAACCAGGACGGTTACCACGATGATCAGGA AGATTCTTTCGTGATGATCGGTAAGAGTGAAGAACAAATGAGAAAGTGGTCGGAGAAGGTTATGGAGCTT GCCAACAACGAGCGCAAGATTCAAGAGGACATGCGAGCGGCAAGAATGAAGGCTGGTCGATTTTCTGGTT CTGAAAGGCAGTACTACCAACATTCTTTCTTCGGTCCCCCTACTCCTGCCACAGAACATCCTCCTATGAC ACCCTTCAACATGCCTCCACTTCCAAACGGGTCGGCTACTCCTTATTATTCTGAAGACGAAGACCCCGAA GGCCTCCGCAGCGGTCGTACAACTCCCAGCATTCTCGGGCATCATCCGTACGCTTATTCCGGTCAACCTT CCGCCAGTAGGCGAGTGCAGAGTCAGCAATCAATGACTTCTGTCATGCCAACAGAGCTTCGCGCTCGGGC TATGACAGAAGATCAGTACGGTCCCAGCATGACACAGTGGCGTACTCAACAACCGATGGCCCCTCCCCTT CCTCGCTTAACGTCTGCCATGTCGGGTATGTCGGTGGCCTCGGAACTTTCCTTTGGCTCTGGACCGAATA ATATAGGTATACGAACTGGTATGGTCCGGCAGATGAGCTCTACGAGATTACCGCGCGCTACTGAAGTGGA CGAAGCAGAAGAGAATCCGGTCGATACTCGGGATTCATATGGGAGGTACGGGTCGCTTAGAGGGATAATG CGCGCTCCTAGTCACGCCATGCCTAGTGTGCCCCACCCTCCACCCCTCCGGAATCGCAGTGCCTCCTCTC CCAATGTCTATCAGCAACCAACTGTCACTGGTGCTGCATCTCTTCCTTATACCGCTGGGCCCAACGGGAC TTGGACCACTTCTCCTCTTGCCTCTACTCTTCAGATGAGCACGCATCCTTACGTCCAAAGTACCCCTGTA CCTGGGTTTGGACCTAGTAGCTCAACGACTCTTGTGGGTGGAACAGCATATTTCAATAAGCGAATGAGCA ATGAGAAGAGATCAAGTGGTGAGAGTCATCACTCCACGACCACCACCGATACTTCAGACCAGACCAGTCC TGCTACGCCATATGGCAGCGGCAACGGAGATATTCGGGGCCCATCGAGACAAAACAGTGGCGACAATGTT TCAGGAAGTGTGTTAGTCAAACTGCGGTTTGGCAATGTGAGTAATTCGTACAGCTTGATACGACAAACAA ACTAATGTGTGTTTAAAGGATCAATTTATTCTCGGCGTCTCACAAGGGATCGACTTTATCACTCTCTATC AGAAAATCCACAAGAAGATTCGCCTGTGCAGCAGCTCTAACCGACCGACGAATGAGCATGACAAGCTTCA GATCCGCTATGTCGATAATGACGGAGATGAGATCCAAGTCAAGTTTGATTCAGATGTGGAGCTGATGTTT GAGGATGCGAGAGATCAGGCTGGACATATCAATTTGATTGCCAGGTGGGCTGAGGACCGACGAGGTACCC CACAAGGAGAGATTTATTGAGGAGAGAGACGTTATTTAAATATAAAGAACAGAGAGAAGTTCGATCATGG CTTATTTTATTTCTCATTCTATTTTCAAAGAAGTTTGTCAGTTTCGTATATTTATTCTTCTATGTTTCCT TCTTTCATGTTTTCTATCTTAGATGGCTGGATTTGGGGTTTGGGTAGTGTCTTCTGTCGTGTTCATCTCT TTTATGATCAGAAGTAGAGTACATTTTGTATCAAGTACGTACAGTATGAAGAAATCTCATGAGTCCCAG
Protein Sequence	>gi\|799338496\|ref\|XP_012051688.1\| cell division control protein 24 [Cryptococcus neoformans var. grubii H99] MSVSGPISRRRIGSVSQRGNESLPQLDIQSIQMPSNPQNALALKTAALSTSTRSLHQICSILKKRLLCVD GFKAFLEQPPNAEPLDVVSHMCHLFRLGSPLCHLYNLLIPSFVDCLSPLYADLPAPAKIEYDFPQFYDSP NGVRNWAKRPENAKPCQRYIAAFCMAMKKRIEEGRWTSDMWALHELWGKSTGEDIEAYDSTGLMKVLSTV EEMLDNLPESAMSPISPQTPFTASGSIAQRAQSRQSYDLPFSMGGIGSGASAVANMAATMNGGVHVETGP SENSPTAAEMQRGLSTSLAEANAFKSVEELVASEKSYVQELEILVRCSQEMLEAQLVSTETNHQIFSNLS KILDFHRKFLIKLETEYEPIQERGPGAWAEGVWGRPFILSEAEFDCYGPYCANYLDAITVVNEQMPILMR GQELSPGERPCLDPQRELQAFMIKPIQRITKYGLLLDAILHATAKHEYPFRPELEEASAAVKRIAAGINE VTDFKAKQATVRELIERVDDWKGHDVDKFGPLHIDDHFTVTKADQPREYHVFLFEKMMLCCKEITPEKKK QNKNSSMLRKDRGTSKSGPLDKKKLALKGRIFVSNIKEATILPTEPGDAYGVARLLIGWTIPLRNQDGYH DDQEDSFVMIGKSEEQMRKWSEKVMELANNERKIQEDMRAARMKAGRFSGSERQYYQHSFFGPPTPATEH PPMTPFNMPPLPNGSATPYYSEDEDPEGLRSGRTTPSILGHHPYAYSGQPSASRRVQSQQSMTSVMPTEL RARAMTEDQYGPSMTQWRTQQPMAPPLPRLTSAMSGMSVASELSFGSGPNNIGIRTGMVRQMSSTRLPRA TEVDEAEENPVDTRDSYGRYGSLRGIMRAPSHAMPSVPHPPPLRNRSASSPNVYQQPTVTGAASLPYTAG PNGTWTTSPLASTLQMSTHPYVQSTPVPGFGPSSSTTLVGGTAYFNKRMSNEKRSSGESHHSTTTTDTSD QTSPATPYGSGNGDIRGPSRQNSGDNVSGSVLVKLRFGNDQFILGVSQGIDFITLYQKIHKKIRLCSSSN RPTNEHDKLQIRYVDNDGDEIQVKFDSDVELMFEDARDQAGHINLIARWAEDRRGTPQGEIY
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: Cdc24 is a Ras1 effector in C. neoformans to mediate the ability of this fungus to grow at high temperature. Ras1-Cdc24 signalling cascade functions specifically through one of the three Cdc42/Rac1 homologues in C. neoformans (Nichols et al., 2007).
References	*Nichols et al., 2007:* Nichols CB, Perfect ZH, Alspaugh JA. A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. Molecular microbiology. 2007; 63(4); 1118-1130. [PubMed: 17233829].


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CDC24