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CDA1

Victor ID 5282
Gene Name CDA1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23889088
NCBI Protein GI 799333267
Locus Tag CNAG_05799
Genbank Accession CP003826
Protein Accession XP_012050538
Taxonomy ID 235443
Chromosome No 7
Gene Starting Position 908094
Gene Ending Position 910638
Gene Strand (Orientation) -
Protein pI 4.17
Protein Weight 45877.18
Protein Length 470
DNA Sequence 
>gi|799350762:908094-910638 Cryptococcus neoformans var. grubii H99 chromosome 7, complete sequence
TGTGAAGCCATCCATTGAAAGCTTGTTCGCGAGGTATGCACAACAACACGTTCAGATCGATCGAATGAAA
AGTACATGGATGTTCAAAACGTTCAAAATGTCCATGATATTCATAATGGATCAAACTTTGAAAGATCAAA
AAGACAAATGGTTCACAATGAAAGACGGTTCAACGAAAGATGGTTCAGCTATTAATACTTGATGGATTTG
AGGCAAAGTATAGCCCAAGTATAGCCCCATTAGACACACTTCCCTCCCCCCCCACCACCCATCCCCATCC
ATCGTTACATTGAAAGCCTTGAAATACTTAGGCGACATATACCATACCAACCGCAACAGCGGCAAGAGCA
ATGAGGGCACCACCCATGGTGGCTGATCGACCAGACCCGCTGGAAGAAGTGTTAGAGGCGGCGCCTGTAG
AAGCGCTGGCGCCAGAACCACTAGTGGTGGAGGCAGCAGAGCCAGCGGCAGTGCTGCCAGTGGCCTCAGA
AGGTGCAGAGACTTCAGCACCGGTAGCAGTGCCAACAATGGGCTGGAAGAAGGTAGACTGGGAGCCGGTG
GCTGCAGTGATCTGAGTAGTAGTCTGGTTGGATGAAGTCTCAATGTATGCTTCGGAGGCTGTGTATCATC
TTAGCCCACAACCTTTTCTGATTAGCGGAGGCAACTTACTGTCCTTGCCCAAACAGTTGATGATGGATTT
GAGCTGATAGGTACCGTTGGCGAGAACTTGGGGCAAAATGTAACCAACAGCAAGGTCAACACTCTGCTGG
TAGACTGTAAAGGTATACGTCAGGATTATTATTGCAAGACGGATAGACAAGACTTACTGTCGTGCTCAAG
AGTGATGAAACCAGTGTCCAACTTTGGGGCGTATTCGGTGAGAATCTTCTCAAAGGTCTCATAAGAAGAA
GCGCCGGTGGCGGTACCACCACTGATGTGCCAGTCGTTCTGTCATTTCGTTAGTAAGATTATTGCGAAAG
TCAAGATAAGCCTACAGTGTCAAAGTTAACAGTGGTTGAGCCATCAGTGTAAGAAGTCCAGATAACAGGG
GTCAAGCCCATCTGAGCAGCAATAGCTCGAACACGGTCATCAATGTCACCATAAGGGGGTCGGAAAGTGT
TTGGGGTGACGCCAAGGGTGTCCTTGATGACCTTCATTGTCCAACCAAGCTCGGCAACAATTTCCTCGTT
GGTAAGAGTAGTAAGTGCGGGGTGAGACCAAGTGTGGATAGAGATCTGGTGTCCAGACATGTATTCGGTT
TGGAGCATCTCGGGTCGAGAAAGGACACGAGAGCCGACAACGAAGAAGGTGGTCTTGATGTTCTTCTCCT
GAAGGTAATCAATTAGGAGAGGGGTGAAGGGAGAAGGCCCATCATCGTAAGAGAGACCCCAAACATTCTT
GTCAGGACACTCGACAATGTCGGTTTCCCGAGTGCAACCACCACAAGTCCACCAGCATCGACCGTCGCTG
ATAGCAGCCGCGTCAGTAGAACAATCGCCCGTTGTCACATTATAACTGGGCACCTTGGACAAGTCGATCT
AATCCAACTGTTAGCTCTTCTGGTGCCTTTTCGGACTCAAACACAACTCACCTTGGCCATCCAGTCCTTA
ACCAAAGAGGAGTTGGTAGGAGGGGTGACATCTAAAGCTGGATAATCGGCGATGGTGAGGGCACTGGTAG
GGAGGACAGGGGCACCAGAAACGGTAGGTGTGGCACCGGCCGCGAAGGTAGAGTAGAGGGCCACAGTAGA
GTCAGTGGGGGCACCAGACGTGAGCTCGCTCAAAGCACTAAAAACGCACTTGTCAGCATTTGGCCTCTAA
AAGCTACGTTTGGTTAAAGGAATTAGTGGGAGGATAATGATGGGCACGGTTCGCGTGGGCGCTTGGCTCA
TTGTTCGCTATGGCCTGTGGCGAGACTGGAGGTTGACGGAAAAGTCGAGAGTACTCACGGAATGGAGAAA
CCAGAGGGACCGGTAGAGTCAGCAGTCTTAGTTAAGATGCTACTGTCAACCGATGTGCCTGTAGTCTGCG
CCACCACACCAGCGAGGGAAATTAGAAGAGCAGAGAAGGCAGCGAATGTAAACATGGCGAAATTCCGCTT
TTGGAGCGAGAAGGAAGAGAAGTTGACAAGAGATGAAAGAGTGATAGAGTTGATGCTGAAGAGCTGTTTG
AAGTTGGATTTTTGCTGCTGACAAGTAAGCTGTGCTGCTCAATGTGGCAATGTGACAAAACGCCAAGAAA
ACGAAAAGGGGCGTCGGCTATAGCGGGAAGACGCGTCTCAAGTCATCGTGTGGGAATGGCAGCGGCGGGC
GTCGCACTCACCGGGACGGAGGAAAGAAATGAAGAGGCTGCTTGAATGCGAGGAGGAAGAGATGGAATCA
CAGAGCGTGGGTGCTGAGGAGGATAAAAGTTAATGATGAAAAGAAGAGGGCACGCGCTTTTATCCTTTGG
CTGATGGCTGGAAGCGCCCAGGGCCTGGAAAGTAAATCGCGATAACGATCTACCAAGGCACGCTAGAAAT
GCTCTCCCTGACCTGCGCTGTTCGG
Protein Sequence 
>gi|799333267|ref|XP_012050538.1| chitin deacetylase [Cryptococcus neoformans var. grubii H99]
MFTFAAFSALLISLAGVVAQTTGTSVDSSILTKTADSTGPSGFSIPALSELTSGAPTDSTVALYSTFAAG
ATPTVSGAPVLPTSALTIADYPALDVTPPTNSSLVKDWMAKIDLSKVPSYNVTTGDCSTDAAAISDGRCW
WTCGGCTRETDIVECPDKNVWGLSYDDGPSPFTPLLIDYLQEKNIKTTFFVVGSRVLSRPEMLQTEYMSG
HQISIHTWSHPALTTLTNEEIVAELGWTMKVIKDTLGVTPNTFRPPYGDIDDRVRAIAAQMGLTPVIWTS
YTDGSTTVNFDTNDWHISGGTATGASSYETFEKILTEYAPKLDTGFITLEHDIYQQSVDLAVGYILPQVL
ANGTYQLKSIINCLGKDTSEAYIETSSNQTTTQITAATGSQSTFFQPIVGTATGAEVSAPSEATGSTAAG
SAASTTSGSGASASTGAASNTSSSGSGRSATMGGALIALAAVAVGMVYVA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Cda1 is one of the four putative chitin/polysaccharide deacetylases in C. neoformans. The chitosan production was abolished only in the cda1ÃŽâ€cda2ÃŽâ€cda3Άtriple-deletion strain however CDA1 single deletion was not sufficient to affect the chiitosan levels (Baker et al., 2007).
References
Baker et al., 2007: Baker LG, Specht CA, Donlin MJ, Lodge JK. Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans. Eukaryotic cell. 2007; 6(5); 855-867. [PubMed: 17400891 ].