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CCP1

Victor ID 5281
Gene Name CCP1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23884881
NCBI Protein GI 799327664
Locus Tag CNAG_01138
Genbank Accession CP003824
Protein Accession XP_012049342
Taxonomy ID 235443
Chromosome No 5
Gene Starting Position 1101941
Gene Ending Position 1103696
Gene Strand (Orientation) +
Protein pI 9.11
Protein Weight 40301.39
Protein Length 377
DNA Sequence 
>gi|799350697:1101941-1103696 Cryptococcus neoformans var. grubii H99 chromosome 5, complete sequence
ACTTGGCCCCCCCCTCATTGTTCATATTTGTTCCCACAATCTTTTTATCTTCAATTGCCCACATATTTAT
ATCATCATGTCTTTTAGAGCTCCCAATTTGATACGATCAACTGTTGGCCGAAGAGCCGGTCAAACTTTGA
ACCTGCGTTCTCAGGTTATTCGACGACGATTTGCAACTGAGGGTGGACCGGAGATTGTAAGCAGCTTTAT
CAGCCTTGTTGACTGCAACATTTTACTGAACAGACGCAGACCAAACCATCTGCTCCACGATCGTCCAACA
CTGGCTATATCTTCGCAGGTCTCGGTGTTGCTGCCGTCGGAGCTGCATATTACTTCTACGGCACCGGCAG
GACCGAGCACGATTCTACCAATAAAGCTGATACGGTAGTGCGTGAAGCTGTTGCCACGGTCGAGGCCAAG
ACGGGTCTCAGAAGAGGCAAGGACGAGTATCAAAAAGTCTATAATCGAATTGCAGAGACTCTCGACAAGG
AGGGTTACGACGGTTAGTTTTCAATCACTTGCTGAATGCGGTACCAGAGCACGGTGACTGATAAGGAAAT
ATCAGACGGTTCTTTGGCTCCCGTCCTTCTTCGCTTGGCTTGGCACGCCTCCGGCACCTATAGCAAAGCG
GATGGAACTGGAGGATCGAACTTTGCTACCATGAGGTTCAAGCCCGAGGCTGAGCACAGCGCGAACAATG
GCCTAGTGGGTGTTGATGCAAATGGACATATTTCTTGAGCTGACCATATCAAAGCATGTTGCCAGGGAGC
ATATGGAAAAGATCAAGCAGGAGTTCCCCTGGATCTCTTATGGGGACCTATGGACCCTCGGTGGAGTCTG
TGCCATCCAAGAGTCAGGCGGCCCTACCATCCCTTGGAGGCCTGGTAGAATTGACGGATACGCCGCTCAA
GTCACTCCCGATGGCAGGCTACCTGATGCCACTCAAGCCCAAGACCATTTGAGGTTTATCTTCAACCGCA
TGGGGTAAGTCACCAGGTTTAGTAAAAAGATTAGGAAAACTTACAGCACTGTAATAGCTTCAATGACCAA
GAAATTGTTGCCCTTAGCGGAGCTCACGCCATGGGACGATGTCATCCTAGTAAGTTTTTTTTTTTCAATG
ATCAACATGAAATGTCTGACAGATCTTTAGACCGATCGGGCTTTGATGGCCCTTGGACTTTCTCCCCTGT
AACCTTTTCCAACCAGTACTTTGCTCTTCTCCGCGACGAGCCTTGGCAATGGAAGAAGTGGTGAGTACTC
TATTATATCACCGGAAACGGTCAATGGCCTTATCCTAGTATTACAGGACCGGACCTGCCCAGTTCGAAGA
CAAGAAGACAAAGACCTTGATGATGCTTCCGTAAGCTGAGACCAGAGTCTCCCGACACGCCGAACTGACC
TTGATGTTGACCCATTTATACAGTACGGATATGGCGCTCGTTAAAGACAAGTCCTTCAAGAAGTACGTTG
ACATTTATGCCGATAACGAAGAGAAGTTCTTTAGCGAGTGAGTGCCTGGTAATGATAAAGCGTTTGCTGG
CAGTCGCTGACCCGACCATAGCTTCGCGAAAGCATTCTCCAAGCTCATTGAGCTTGGTGTCCCTGAGAGG
CAATGGGCTGGGGAACCTTGGACTATGGCAACCAGCGATTAACTTTGGTATACGTACGATAGTAACTCGA
GTCAATACGTGATAATGAGAAATAATGCAGCCAATTATTTTCACTGCGTTAATGTCCTTGCTGTTCGTTG
TTTGAC
Protein Sequence 
>gi|799327664|ref|XP_012049342.1| cytochrome c peroxidase, mitochondrial [Cryptococcus neoformans var. grubii H99]
MSFRAPNLIRSTVGRRAGQTLNLRSQVIRRRFATEGGPEITKPSAPRSSNTGYIFAGLGVAAVGAAYYFY
GTGRTEHDSTNKADTVVREAVATVEAKTGLRRGKDEYQKVYNRIAETLDKEGYDDGSLAPVLLRLAWHAS
GTYSKADGTGGSNFATMRFKPEAEHSANNGLHVAREHMEKIKQEFPWISYGDLWTLGGVCAIQESGGPTI
PWRPGRIDGYAAQVTPDGRLPDATQAQDHLRFIFNRMGFNDQEIVALSGAHAMGRCHPNRSGFDGPWTFS
PVTFSNQYFALLRDEPWQWKKWTGPAQFEDKKTKTLMMLPTDMALVKDKSFKKYVDIYADNEEKFFSDFA
KAFSKLIELGVPERQWAGEPWTMATSD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Ccp1 is a mitochondrial antioxidant that catalyzes the degradation of hydrogen peroxide. The mutant showed attenuated resistance to exogenous oxidative stress in vitro but does not diminish the virulence of C.neofromans in a murine model (Giles et al., 2005).
References
Giles et al., 2005: Giles SS, Perfect JR, Cox GM. Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans. Fungal genetics and biology : FG & B. 2005; 42(1); 20-29. [PubMed: 15588993].