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CBK1

Victor ID 5279
Gene Name CBK1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23887056
NCBI Protein GI 799335528
Locus Tag CNAG_03567
Genbank Accession CP003827
Protein Accession XP_012051006
Taxonomy ID 235443
Chromosome No 8
Gene Starting Position 1296381
Gene Ending Position 1298942
Gene Strand (Orientation) +
Protein pI 7.6
Protein Weight 59429.17
Protein Length 556
DNA Sequence 
>gi|799350780:1296381-1298942 Cryptococcus neoformans var. grubii H99 chromosome 8, complete sequence
AGAAGAAGACAACCATCGATGCAATAAAGATCGTGGTGTCCGCTGCAGTGTTTCAACTCTAGGAGGATAG
AGTTGTAATGGCTGAAAGTAGATTTGTAATGAGAGGATTATAAATTGGACCCCCGTTCTACTATAATTGA
ACCCTGACGCGTTAAAACCAAACGAGTGTGCTTGCGAGGAAACGCGCATTGTTCATATTTCTCTTTTACA
TCTTATCGCGTGGCCTCAGACGTCGACTGGCTTCGATTACCATTTCCACAGCATGTCGTATCGCCCAATC
CAGGGACAACAACCAGGCCCATCAAATTTTCAACAACAGCAACAGAATATGCTGAACCCTCAAAACATGG
CAGGTCCAGGCCGTACATCACCCATGCCCAGCGTTCCACAGGTTTCTCAACCCAATATTGGTCAACCGGG
CTCCATGAGGCCCGGAGAAGGGCCCATTCCTGCCGCAGCGCAAGCTAATGCCGGTGGACAAGTTCAAGGC
AGTGGTGCAGAGGGCTTGGGATCACTCGCGAGTGATAAAGGACCCGACTACGTGTATTTTGAGCGAAAGC
CTGGGCAATTCTCAGAAGCTGTTCAGGGAAAGGCAATGGGTGCGAAAATGAAGTTGGAGCTGTTTTACAA
GGAGGCCGTTGAAGGTGTGGTTGGGAGAAAGGAGAGGTGAATATTGTGGAGACATTAAGTTTTTGAATTA
TTCGCTAATTTGTCATCTAGGCGAACGGCCCTCGAAAAGCAGCTTGCAGCCGATGCTCTCACTCCTGATT
CCTTAAAGGCCCGTCAATTAATCAATCTCGGCCGTCGAGAATCAAAGTGAGCTTTTTATCATCATCGGTT
CATCGTCCGCTTACATATAATAGCTATCTCCGTCTTCGACGTACCCGGATTGGCCTTGACGACTTCCGTA
CCGTCAAGGTTATTGGTAAGGGTGCATTCGGTGAAGTCAGACTCGTACAAAAGGCCGACACTGGTAAAAT
TTACGCTATGAAGACTTTGAGGAAGAATGAAATGTTCAAAAAGGACCAGGTAGGTGTTAATTTTTAATGA
TTTGGTCTGAAAGCTTATGTGGAGACAGCTTGCGCATGTTCGAGCTGAAAGGGACGTCCTTGCCGAGAGT
AATTCCCCTTGGGTCGTGCAACTGTACTACTCTTTCCAGGACACGCAGTATCTTTACCTTGTCATGGAAT
TCCTCCCCGGTGGTGACTTGATGACTATGTAAGCTTCAAAAGGAAATGCAAAGTTTAAGCTGACCATAAA
TAGGCTCATCAAATACGACACTTTCTCGGAGGACGTCACCAAGTTCTACATGGCCGAATGTATCTTGGCT
ATTGAGGCTGTGCATAATCTTGGTTTCATCCATCGTGACATTAAACCCGATAACATCCTCATTGACTCGC
TGGGTCACATCAAACTCTCTGACTTCGGCCTTTCCACCGGTTTCCACAAGCAACACGACTCTGCCTATTA
CCAGCGTCTTCTCGGCGGCGGCGACGTTTCTGGCAACAATCGACAATCTCAAGCTGCCGCTGGGGCTCGG
AATAGTGTCATGGTAAATGCGATCAACTTGACGATGACTAGCAAGCAAGATATTGCCACCTGGAAGGCGA
ACAGGAGGAAGTTGGCTTATTCTACTGTCGGAACCCCTGACTATGTGAGCTGCATAATCGGTACCAAAGT
AACAACTCTGCTAACTCTTGATAGATTTCCCCGGAAATCTTTTTGCAGCAGGGTTACGGGAAGGAATGTG
ATTGGTGGTCCCTTGGTGCAATCATGTTTGAGTGTCTTGTCGGTGCGTCCCATCATCCTTGTTATGATTG
TCTACTTAAGAAACATGCTTAGGCTATCCTCCCTTCTGTTCTGAGAATGCCCATGATGTCTACAAGAAGA
TCATCGACTGGAGAAATTACTTGTTCTTCCCTGATGATGTTCATCTCAGTCGAGAAGCCGAGGACCTGAT
CAGGCGGTCAGTATCCTATACGTATCCCTGATTTGGAACGGTTCATTGACTATTGTTTAGGATGCTTTGC
GAGGCCGACCGAAGATACACCGTCGAACAACTTAAAGCCCATCCCGTGAGTTCCAGCTCCCTTCTATTTG
AATGAAATTGACACAACCCTCTGCAGTTTTTCTACGGTGTCGACTGGGCAACCATACGGGAGATTGATGC
TCCCTTCGTTCCCCACCTCCGATCTATCACCGATACTTCCTACTTCCCCACCGATGAACTCGACCAGGTC
CCGGATATCCCAGTTGGGGCCGAAACTGGGAGCGATGCGAAGAAAGATTTGGCGTTCTTGGGTTATACGT
GAGTTTTCCTTGGCAGCGGCACAATACAGAACGGACAACTGACGGGCACATAGCTTCCGACGATACGAGA
TGCTGTAGAAAACTTATTTCTTTGCCGCTTTTTATGAGATTGTGTATGATACAGGTTGTGGTTTTGGCAT
CTTTTTTTTTGTAGAACTGAACATGAGCATGAAAAATGAGTATTTGCATGCGCTGGGAGGTATTTCGCGT
TTTATTTTTAAGGAGTGCGATGGATGAATGGTCCACGATAGG
Protein Sequence 
>gi|799335528|ref|XP_012051006.1| AGC/NDR/NDR protein kinase [Cryptococcus neoformans var. grubii H99]
MSYRPIQGQQPGPSNFQQQQQNMLNPQNMAGPGRTSPMPSVPQVSQPNIGQPGSMRPGEGPIPAAAQANA
GGQVQGSGAEGLGSLASDKGPDYVYFERKPGQFSEAVQGKAMGAKMKLELFYKEAVEGVVGRKERRTALE
KQLAADALTPDSLKARQLINLGRRESNYLRLRRTRIGLDDFRTVKVIGKGAFGEVRLVQKADTGKIYAMK
TLRKNEMFKKDQLAHVRAERDVLAESNSPWVVQLYYSFQDTQYLYLVMEFLPGGDLMTMLIKYDTFSEDV
TKFYMAECILAIEAVHNLGFIHRDIKPDNILIDSLGHIKLSDFGLSTGFHKQHDSAYYQRLLGGGDVSGN
NRQSQAAAGARNSVMVNAINLTMTSKQDIATWKANRRKLAYSTVGTPDYISPEIFLQQGYGKECDWWSLG
AIMFECLVGYPPFCSENAHDVYKKIIDWRNYLFFPDDVHLSREAEDLIRRMLCEADRRYTVEQLKAHPFF
YGVDWATIREIDAPFVPHLRSITDTSYFPTDELDQVPDIPVGAETGSDAKKDLAFLGYTFRRYEML
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: One of the five components of the homologous RAM-signaling pathway in C. neoformans, deletion of CBK1 gene leading to morphological change of this fungi (Walton et al., 2006).
References
Walton et al., 2006: Walton FJ, Heitman J, Idnurm A. Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi. Molecular biology of the cell. 2006; 17(9); 3768-3780. [PubMed: 16775005 ].