Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

CAN2

Victor ID 5277
Gene Name CAN2
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888486
NCBI Protein GI 799324835
Locus Tag CNAG_05144
Genbank Accession CP003823
Protein Accession XP_012048738
Taxonomy ID 235443
Chromosome No 4
Gene Starting Position 545387
Gene Ending Position 546951
Gene Strand (Orientation) +
Protein pI 5.15
Protein Weight 24021.13
Protein Length 239
DNA Sequence 
>gi|799350666:545387-546951 Cryptococcus neoformans var. grubii H99 chromosome 4, complete sequence
ATTTGTGGACAGCTTTTGTCGCTGCGTCTTCTTCAGCTCGTCCAGCTCTCCGCTCCCAGCCACCTTTCCC
GGCCCCGCTTCCTCCGATCAACCACCTGTACCGCACGCGGTGCATATAACCACGATACCCCCTCCAGCGA
GCCTCTGTTGCCCGCTGTCCGTCGCAAAAATACTCACATCTCACGTCAGAGCCATCTCCCCCGTCGCACA
GTCGCTATATAGAACTCGGCTGGCCTCATACAGAGCCCACATTGCACATAGCCTTCCAAGACCCGCATCC
GGTCTGCGTCCGCGTCCCATCATTTGTTCCTCCAGATCTATAAACACTACCAGCGTCGCCAACATGCCTT
TCCACGCTGAACCCCTCAAGCCCTCCGATGAGATTGACATGGACCTTGGGCACTCTGTAGCTGCCCAAAA
GTTCAAGGAGATTAGAGAAGTCCTCGAAGGCAACAGGTACTGGGCCAGAAAGGTCACTTCTGAGGAGCCC
GAGTTCATGGCCGAGCAGGTCAAGGGTCAGGTGAGCAGCTCCTAATTTTGGAACCGTCGAAACGCATCGC
AAAGCTAATCCATGGTAATGCAGGCCCCCAACTTTCTCTGGATCGGATGCGCCGACTCTCGTGTTCCAGA
GGTCACAATTATGGCTCGTAAACCCGGAGATGTGTTCGTTCAGGTATGTTTCTACCCTCGCGGCTTTCGG
TCGGCTTTCGGTTATCGTTGCCCGCGCACAGGATGCGCTGCGGAATGGAGGGGCTAACAAAAGCTTGGTT
GCCTATAGAGGAACGTTGCCAACCAGTTTAAGCCCGAGGACGACTCTTCTCAGGCTCTTCTCAACTACGC
CATCATGAACGTTGGTGTCACTCACGGTCGGTATCTTTCGCCTATGTTAGTATTGCCAAGCCTTCATAGA
CTGACTTGGAACGCCATTAGTCATGGTTGTTGGTCACACCGGTTGTGGTGGCTGTATTGCTGCGTTTGAC
CAACCTCTTCCGACTGAGGAAAACCCTGGTGGGACTCCTTTAGTGCGATATCTCGAACCCATCATCAGGT
TGAAGCATTCTTTGCCCGAAGGAAGCGATGTGAACGACTTGATCAAGGAGAACGTCAAGATGGCCGTAAA
GAACGTTGTTAACAGCCCTGTAAGCTTGTCCCTCATGTGATTAGGGCTATGGGTCGCTCATAGCAAATGT
AGACCATTCAGGGAGCTTGGGAACAGGCCAGGAAGGGCGAGTTCCGAGAAGTTTTCGTCCACGGCTGGGT
GAGTTGCATTCTGTAACTATGAGATGGCTAATTGGCTGACGCCCGTGTAGCTCTATGACCTTTCTACCGG
CAACATTGTTGACCTCAACGTCACCCAGGGCCCTCATCCTTTTGTTGATGACCGAGTGCCTCGAGCGTAG
ATAGAAATAGTTGTAGAAGTAGACTGTCGTACGGATTATCAAGGGTGTATTAATAGACAGGGAATTACAG
GCTCAGTCATTACAGCATAGATGAGATGAAGTTTTTTCTCGTTATTTTGTCAGTATGTGAATAGAATAGA
ATGCATACAACAACAGTATACGCAT
Protein Sequence 
>gi|799324835|ref|XP_012048738.1| carbonic anhydrase [Cryptococcus neoformans var. grubii H99]
MPFHAEPLKPSDEIDMDLGHSVAAQKFKEIREVLEGNRYWARKVTSEEPEFMAEQVKGQAPNFLWIGCAD
SRVPEVTIMARKPGDVFVQRNVANQFKPEDDSSQALLNYAIMNVGVTHVMVVGHTGCGGCIAAFDQPLPT
EENPGGTPLVRYLEPIIRLKHSLPEGSDVNDLIKENVKMAVKNVVNSPTIQGAWEQARKGEFREVFVHGW
LYDLSTGNIVDLNVTQGPHPFVDDRVPRA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Can2 is the main carbonic anhydrase and suggest a physiological role for bicarbonate during C. neoformans growth (Mogensen et al., 2006).
References
Mogensen et al., 2006: Mogensen EG, Janbon G, Chaloupka J, Steegborn C, Fu MS, Moyrand F, Klengel T, Pearson DS, Geeves MA, Buck J, Levin LR, Mühlschlegel FA. Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryotic cell. 2006; 5(1); 103-111. [PubMed: 16400172 ].