Victors

BLP1
Victor ID	5272
Gene Name	BLP1
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23888137
NCBI Protein GI	799340830
Locus Tag	CNAG_04755
Genbank Accession	CP003829
Protein Accession	XP_012052184
Taxonomy ID	235443
Chromosome No	10
Gene Starting Position	486246
Gene Ending Position	492744
Gene Strand (Orientation)	-
Protein pI	7.11
Protein Weight	188481.6
Protein Length	1793
DNA Sequence	>gi\|799350850:486246-492744 Cryptococcus neoformans var. grubii H99 chromosome 10, complete sequence ACTTTTCTCTCGCGTGTAACCGCTGAGGCAACAACACCTGTTTGTTAGTCTCAGGCTTCTCACTTGTATT ATTAAGCGCCCTTCCAACCACACTTCTGGCCCGATTGCTGCTAAAAAGTTGCTGTCGGCAACCCATCGCA CAACACACAACATAACATATCATACATGTCTTACTTCAACCCATTGATGTCTATAAAAAAAAATACTCGT CTTATGTCAAACGCGTCAAGCGATCTCCCGTGTCGTTAGATTTTCGTTATGATCATACTCGTCATACTTT TCCCAGCAGATGCCCCTTTCTCGAGCACATACCAATGCCAAATCATGCTTTGGGTCTTTTCGCTCCCCTC TTTGCAACAGCTTTCCCAATTTTGCTATCTTTAAAAGTCCAAGTCAAGTCCCTATCTTTTATGAACTCGT GTTGAAGAAGGTCGCGCGCCATGGGCCGACTGCGAGGGTCTGTAGCGAGACACTTTTCGTTGAGGAAATC AAGAGCAACAGAAGAAAGATTAATATCAGGCGGAAGAGGCGGTCTAGATCGTTTGTTGAAGAGCTGTTCG TCAAAAAGTCAGTCATTCGCACGAGATATAAAACTTTGACCTGGACACACCTCAAACATTGCAGCAAATT GCTCCATGTCGCCCCAAGGCCTTTTTCCAGACCACATCTCAAGCACAACACATCCCAAACTCCAGATATC AACCTTTCCGGAGTATGAGCGTTCGGAATAAGAATGAATAACCTCAGGCGCCATCCAAAAGACGGACCCC TTCATATTGGTAGCTTGGCCAAAGGAATCATAGGCATCGGCTACAAGTCGAGCACTGTCAGTCCAACTTC TACGGATTTGTTCGCTTAATCCTACCTGTCTGCTTAGAAATACCGAAGTCTGAGATCTTACATATGCCCT GCGCATCCACCAAGATGTTATCACCTTTGAGATCCTGATATCGCTTATCAGCCCTGATCTATGTTCCCAA CAATCTACTCACTCGATGCCAAATATTCTTCGAATGCAAGTACGCTAACCCTTCTAGAATCTGTTCAGTA AAGAATCTGACGAGCTGCGGCTCGAAACGGGCTTGGTTAGGGGCGCGGTAAATTGAGGCAATGGTACCAC CGGGGACATATTCAAGGAAACTATGCGGATGTCAACAATTGCCGATGGGCTACGCTTGTTTATAAGCTGG ACCCACATGGACAAATACTCGGGGCTTGTCTCGTATCCTATTAAGGCGTCAGCGTCATGTAAAGCCTACG TCAAAACCAAAACAAAACAACTCACCCAAATACGCCACAATGTTCTTATGCTCTAAACCCTTCAGCAATT CGATTTCATCCCTCAACGCTTTGACCATCCCTTGCTGCCTTGAGTCATGCCTTTCAATTTCTGTCGCCGG CAATTCGACCTGTTTGACCGCCATCATATCTCCCGTTGTAACATTGAGCGCGATATACACCCTACCATAA GATCCTTTCCCGATAAGCTCGCCTTTGACCCAGTTCACAGTGCCAGGCTTGCCATCAGAGGCAGGTGATT CAGGGATATCGGCTTCGCGGTTGGCCTGAGCACGCGCGAACCTGGTAACTTCCACCAGCTTATGATCCCA CATGCTTGAGCTTCGTCTGTTGTCCTTCTTTCTCTGCTCCTCACTTCTGGGGTCGACAACTTGATCATCC ATGGCAGAGTTGACCTCTTCAGCACCGATGTCGTATTCTGGTGGAAGGTCTTCGTGTTGGGATATCTGAC GCTGAAGGGTGCGGCGTTTGTGATCGGCAACAACTCGAATCGACCGGCGATTCTCCGCTTTATTGAACTT TGATCTATTGAACGTTCCAGGAGGTCCCGAAGAAGGCCCTGGTGCTTGAGGCGCCCTACCCAAAGGTCCT GATCCGGCCTGGGGGCCACCTTGTCTACCAGGTGCTGCACCTGCGGGCAATGGTAGCCCACCGATGATCT CCACTCGACTCGGCGACTCAATCCCGGGTGTTGACGGTATCGACTCAGCTCCTTGCACAATGGGTCTATC CAAATCAATCTGCGGGAAAACCCTGTCGAGATTTTCATACAGTTGCTCGGGCTCCGGACGGAAGTTCCAT TGGTTGGGGTCTCTGGGGCGAGCAAAGGATTTGCCGCGCTTGATGTTGGACCCCTCAACCTCACCATCAC CTTCACCTGTGCCTTCAGACTCAGTTGCGCTATCTGGTGGCGTGCTCGCCGAAAGTACAGGGTTGACTTG ATGATACGCCTGCTGGCTCAAAGAAACAGTGTTGACGATGAGATTAGGTTTCGAAGGTGACGGGCGTATC GCGCTTGTGCGAGATGGAGACGTTTCTGGTGCCCGGACAGGCGGCGTGATAAACAGTGTTGCTTCATCTT CTTCTTCCTCCTTCCTTGGTCTCACGGTCCCTTCTCCGCTTCCTGGTCCCATTTTTGCAATCATCTCCTT CAAATGTCTGTCCCATTGCCCAGCCTTAGCCGTGTCTCCCGAGTTTGTGTCGTTGTCTTCACCCACGCCC TTTCCTGGCCGAACTGTCGCCTCGCTGCTGACTGTGCCAGCTACTGACAAAGTATCAGAGTCGCTCCGAT TAGCAACAGCCCTGGAAACTGATAACCACGAGGACTGTGGGCTTGCGTTATGAGCATAGGGCAACTGTGA GTCGGTGTCGTCAAATGCATTTGTCTCACTGATCCTAGGTTGTTCGACCGGGACAGGTGATGCAGTACGG TATGGAGTCGATGCGCTACCGCTTCCAGCTCGATCGGCCCAAGGGAATGGTGAAGATGGCCGACGAACAG CTGCACCATCTTCGAACATAGTGCGGGCATTGTCTGGAGGGTGAACTTCATCGTAATACGTAGAAGGTCG GCGAGGCGGAATTGTGGTTTCAGGTGAGGTGGGAGGAGGCGGAGAGCGGTCGTAATGGACAGTGTTGGGT CGTGTGATATCGAATGTTGGACCGCGAGCCGATCTTGGTACAGGATTAAACTGCTGCGGGTAGCCTCGCC AGGAATTCGAAGATGTCGCGCTGCTCGGGTGCGGTGACGGGAATGGGACAAGACCTGTGTCAATTATAGC TGGTGCCATGGGTGTCGCCCCCCTAGACGAGGAATGCAGGGGTTCCGGATATCTCCCATCTCTGGCTCTG TCCGATGATGGACTGCGATACGACGTGCTTGTGGCTGCAGGTTGAATATTGCGATGCTCTGCGAATCCTG GAGCAGGGGTGATTGATGTTCTGGGAGGCCCGTAAATCTGACTTTGACGTGAAGTCACACCAAGTGGCCC GCTGGTCATCCTCAAATTATCTACAGATCTAGCAGTGGACAGTGCAGGAGCTTGAAGACGCTCATTACTT GGTTCATGAGCAGCGTAGCTGAAAGGATGTCGAATTCGCTGAGATTCCGGGCGAGGGGTATTGGATGTCC GTCCGCGCTGCCCCGAAGCCGGTGCACGTCCCGTCGCCTGTTGCAATCGAGGGTCATGTAATCGCTCTTG AGCATGTGAGGTTTCAGCGTAAGAAGTATTGGGAAACCCAGATGGTCCGCGGTGAGAGTAGGCGAAATCC GGCAGATACTGTGACTGCGATGGCTGATAAATAGGCTGACTGCTTTGCCGTGGCGGTAGCGCTGGAGACT GAGTCTGATTGGTTCTCGGCGCCGATGTCTGCACCATGGGCACTCGTCCCTCTGAGGGCCTTCTTGAAGA AAGCGACCCTTCTGTTGAAGGGCTGACCATCCAAGTAGACTCCCATGTGGCCGAGTCATCCAAAGGAGCC CCCATCCTAGCTCTGTTCTGAAAGAACTGCTGCCTCTGACGCCTATCTTTCTCAAATGTATGAAATCGAC TTTCCTGTTGCTCTCGCTGCTCTCGCTGCTCTCGTTGTTCCCTTTGTTCCCGTTGCTCCGCCTCCCATGC CGTACGGGCTGCTTCTAGTGCTTGCCTTTGCTCTTCTTCGTGTCTCTGCTCCTCCTCTACCTGCCTCTAC ATTGGTCTTCAATACCGAATCGAAACATATATAGATACTACTCACAGCTCTGGCTTCATCTTCCGCGATT TGCGCTTGTTCTCTTTGCCTCTGCTCCTTTTGCATTTGCTGCATCATCTCCCACAGTTCTCTTTCGCTCT GCTGCTCTCTCTTTGCCAACTCTTCATCTGCTTCGAGTTGCCTTCTTCTCTCTTCCTCCTTCTTTTGCGC CTCCTGTTCCTCCCTTTGGAATTGCTCTATCAATGCGCGAGTCTCTGGGTCAATGTCATCATCCAAAGTA AGCCCGAGTCCTTGGCTGCCTTGCTCTTGACTCATTGCTGGATGGCTAGGACCGGAAAATGCGTTTTCGT TTTGATATGAGTCATTTATTGGTGTTCCAGAACGAGGAAAGACAGAGGTAGCATTGGAAGGCTTGAAGTG ATCGAATTGCGGAGGTAAAGAGAGTTCGTTAAATTCGTAATGTCTGCTAGACGGTCGACTAGACGGGGAA GAACGAATGGAAGGTTCGCCAGCCTGTAATGAGGTGGAATGAGGAGGTATAGGTGGTGTGGGCAAAGCTG GAGAGCTCGTACCCAAAGAAGCCGAGTGTTCTGTAACAGGTGATCTCGATCCACCCGTTGAAGTCGATAG TCGCACACCCGCATTCTGTAACACAGATTTCCTTGTGCTCCTTGACAAACCGGGCGCTGACCAGTCCTCT GCTTCATGTCCTAAATCACTCCAGTCACTGGCACTAAGCTCCCCCCGATTGAGCATTTCTCCGCTGGCAC TACTTACACTACCTTCTTTTGAATGACGACTTGAGACACGGTAAAGTACTGGATTAGACAAATCCGTCGT TATTGGGGGAATCCCTGCACGTCGGGGGTCCGCCGCCGCGCGAAAAGGATGATAATCGGTTTGAGAGACG GGTGGAATGACAGATGCGGCGGACGACGGTGGAACATCGGTTTGCTTGACTAGGAATTTGAGGCTAGCTC GAGAGTCTCCCAGGGTGCGGCAAATGTTGAGAAGTGCAGCAGGTAATATAGGTGTTTCATCTGCCGGTTC TCCAATTTCGGTACGATACATCGACAGAGTTGGGTAATCTTCATCTCTAATACGCAGCTATGAACAATGT CAGCTATGTCTAACGGGTATAAACAGAACTTACTTTTGAGAATACTTTCTCACGTATACCTTCAGCAGTA TTTATCCCTGTAATATCTACCAGATGAAACGCTTCGTTATCAGTCGTCACTTGCAGTCTGACCTGTTGTC CTTGCACTGAACCCGACCGATTTCTGTGCCCTATTCCCACACTCATGATGCTCCCATGTTCGCTGCCAAT GGCAGGGCTTATCACATCGTCGGGACTTGCCACTCTTGTTGGATTATGGGGATGATACGCAGGAGGAGCA GAAAATGGTTGCCCATGCGCGGTTGACGGGGATTGGGAAACGGGGGAAGGCATTGTAGACTGCCGAGTGA TGGGTGATGGTAATGGGGGAAGAGCACGCGATGGAGAGTTGGGAACTTGTTGGTGGAATGATGTTGCACC TGTGCTTGAAGGATGAGGTTCTGGGAAGAGTCGAGGTGTATGTTCCGGAGTTGGTGTTGTAAACGCCCGT TGAAGATGCCGCTGCGGTTGAGGGGGCGGTTGTGGTGGTCCTGACGATATCTCTGGAGTGTGACCATATG CTGTTGGCGCAGGCGATGGCGTTGGTACCAACGGCTGTGGACTTGGGAACGCCGATATAGAGGGTAAAGG GGAAGATTGAGGTGCAGGAATTGAAGGATAAGGCAAGCCCCCTCGTTCTTTGATACTATGGGATGGTGAT GCTGGCTGAGGGATGGATACTGAACTGGGACCACCTCTCCCGGAGCTCGATGAGACACTGATAGGTGATA CTGCTGACGGTGATTTTTGACTCCCAGCTTTGGGCGGAGAGTTTTCCTCATCAGAGTTGTCTGGGTTTGC GATGAATAGTCCAGGCATAACACCGCGCCGACGCGCACCTTGAGGACGACGAGGGAGCGTCGGAGTGGAT GGCCCAGCACCGGCAGACCCAGTCGAAACTGAGAGCTGCGGGTGATGAGACATCTCGAGGTTATGCGGAA AAGGGTTACTTGTGGGTTGACCAGATTATGTGGAAGTAGGAATACAATTATGGTGGTGAAAAGGTGAATG GCCGCGAGAGGGATGACGAAGAAAAAGTCTGCGTGGGGAAGACAAAGGTGGGTTGATAATCGCACGAGTT CGGAAGCGCGAAGGTGGGGGTTGTTGTCAGCTCAAATCTACGCATTTCGGCAGCTTTCTTGATCTATGGC GCCGTGGACAGTGGGCAGAATATCGACTCACAGCACTTGGCTCTCTATTTCATCTCTCCTGCTGGCTTAT TCGCTGTCCAGTTTTTCTTGTCTCGGCCGCGATTGTCAGTAGTGGCGTGCCAAGCCGGCATGGGACGGCA GGAATGAAGGAGGTAAAGAATGTTATGGAGATGAAATATGTACGGAAGACATGCATGTA
Protein Sequence	>gi\|799340830\|ref\|XP_012052184.1\| STE/STE11/BCK1 protein kinase [Cryptococcus neoformans var. grubii H99] MSHHPQLSVSTGSAGAGPSTPTLPRRPQGARRRGVMPGLFIANPDNSDEENSPPKAGSQKSPSAVSPISV SSSSGRGGPSSVSIPQPASPSHSIKERGGLPYPSIPAPQSSPLPSISAFPSPQPLVPTPSPAPTAYGHTP EISSGPPQPPPQPQRHLQRAFTTPTPEHTPRLFPEPHPSSTGATSFHQQVPNSPSRALPPLPSPITRQST MPSPVSQSPSTAHGQPFSAPPAYHPHNPTRVASPDDVISPAIGSEHGSIMSVGIGHRNRSGSVQGQQVRL QVTTDNEAFHLVDITGINTAEGIREKVFSKLRIRDEDYPTLSMYRTEIGEPADETPILPAALLNICRTLG DSRASLKFLVKQTDVPPSSAASVIPPVSQTDYHPFRAAADPRRAGIPPITTDLSNPVLYRVSSRHSKEGS VSSASGEMLNRGELSASDWSDLGHEAEDWSAPGLSRSTRKSVLQNAGVRLSTSTGGSRSPVTEHSASLGT SSPALPTPPIPPHSTSLQAGEPSIRSSPSSRPSSRHYEFNELSLPPQFDHFKPSNATSVFPRSGTPINDS YQNENAFSGPSHPAMSQEQGSQGLGLTLDDDIDPETRALIEQFQREEQEAQKKEEERRRQLEADEELAKR EQQSERELWEMMQQMQKEQRQREQAQIAEDEARARQVEEEQRHEEEQRQALEAARTAWEAEQREQREQRE QREQREQQESRFHTFEKDRRQRQQFFQNRARMGAPLDDSATWESTWMVSPSTEGSLSSRRPSEGRVPMVQ TSAPRTNQTQSPALPPRQSSQPIYQPSQSQYLPDFAYSHRGPSGFPNTSYAETSHAQERLHDPRLQQATG RAPASGQRGRTSNTPRPESQRIRHPFSYAAHEPSNERLQAPALSTARSVDNLRMTSGPLGVTSRQSQIYG PPRTSITPAPGFAEHRNIQPAATSTSYRSPSSDRARDGRYPEPLHSSSRGATPMAPAIIDTGLVPFPSPH PSSATSSNSWRGYPQQFNPVPRSARGPTFDITRPNTVHYDRSPPPPTSPETTIPPRRPSTYYDEVHPPDN ARTMFEDGAAVRRPSSPFPWADRAGSGSASTPYRTASPVPVEQPRISETNAFDDTDSQLPYAHNASPQSS WLSVSRAVANRSDSDTLSVAGTVSSEATVRPGKGVGEDNDTNSGDTAKAGQWDRHLKEMIAKMGPGSGEG TVRPRKEEEEDEATLFITPPVRAPETSPSRTSAIRPSPSKPNLIVNTVSLSQQAYHQVNPVLSASTPPDS ATESEGTGEGDGEVEGSNIKRGKSFARPRDPNQWNFRPEPEQLYENLDRVFPQIDLDRPIVQGAESIPST PGIESPSRVEIIGGLPLPAGAAPGRQGGPQAGSGPLGRAPQAPGPSSGPPGTFNRSKFNKAENRRSIRVV ADHKRRTLQRQISQHEDLPPEYDIGAEEVNSAMDDQVVDPRSEEQRKKDNRRSSSMWDHKLVEVTRFARA QANREADIPESPASDGKPGTVNWVKGELIGKGSYGRVYIALNVTTGDMMAVKQVELPATEIERHDSRQQG MVKALRDEIELLKGLEHKNIVAYLGYETSPEYLSIFLEYVPGGTIASIYRAPNQARFEPQLVRFFTEQIL EGLAYLHSKNIWHRDLKGDNILVDAQGICKISDFGISKQTADAYDSFGQATNMKGSVFWMAPEVIHSYSE RSYSGKVDIWSLGCVVLEMWSGKRPWGDMEQFAAMFELFNKRSRPPLPPDINLSSVALDFLNEKCLATDP RSRPMARDLLQHEFIKDRDLTWTFKDSKIGKAVAKRGAKRPKA
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: BLP1 gene knock promoted the phagocytosis of Cryptococcus by macrophages in vitro (Chun et al., 2011).
References	*Chun et al., 2011:* Chun CD, Brown JC, Madhani HD. A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans. Cell host & microbe. 2011; 9(3); 243-251. [PubMed: 21402362].


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BLP1