Victors

BCK1
Victor ID	5271
Gene Name	BCK1
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23888137
NCBI Protein GI	799340830
Locus Tag	CNAG_04755
Genbank Accession	CP003829
Protein Accession	XP_012052184
Taxonomy ID	235443
Chromosome No	10
Gene Starting Position	486246
Gene Ending Position	492744
Gene Strand (Orientation)	-
Protein pI	7.11
Protein Weight	188481.6
Protein Length	1793
DNA Sequence	>gi\|799350850:486246-492744 Cryptococcus neoformans var. grubii H99 chromosome 10, complete sequence ACTTTTCTCTCGCGTGTAACCGCTGAGGCAACAACACCTGTTTGTTAGTCTCAGGCTTCTCACTTGTATT ATTAAGCGCCCTTCCAACCACACTTCTGGCCCGATTGCTGCTAAAAAGTTGCTGTCGGCAACCCATCGCA CAACACACAACATAACATATCATACATGTCTTACTTCAACCCATTGATGTCTATAAAAAAAAATACTCGT CTTATGTCAAACGCGTCAAGCGATCTCCCGTGTCGTTAGATTTTCGTTATGATCATACTCGTCATACTTT TCCCAGCAGATGCCCCTTTCTCGAGCACATACCAATGCCAAATCATGCTTTGGGTCTTTTCGCTCCCCTC TTTGCAACAGCTTTCCCAATTTTGCTATCTTTAAAAGTCCAAGTCAAGTCCCTATCTTTTATGAACTCGT GTTGAAGAAGGTCGCGCGCCATGGGCCGACTGCGAGGGTCTGTAGCGAGACACTTTTCGTTGAGGAAATC AAGAGCAACAGAAGAAAGATTAATATCAGGCGGAAGAGGCGGTCTAGATCGTTTGTTGAAGAGCTGTTCG TCAAAAAGTCAGTCATTCGCACGAGATATAAAACTTTGACCTGGACACACCTCAAACATTGCAGCAAATT GCTCCATGTCGCCCCAAGGCCTTTTTCCAGACCACATCTCAAGCACAACACATCCCAAACTCCAGATATC AACCTTTCCGGAGTATGAGCGTTCGGAATAAGAATGAATAACCTCAGGCGCCATCCAAAAGACGGACCCC TTCATATTGGTAGCTTGGCCAAAGGAATCATAGGCATCGGCTACAAGTCGAGCACTGTCAGTCCAACTTC TACGGATTTGTTCGCTTAATCCTACCTGTCTGCTTAGAAATACCGAAGTCTGAGATCTTACATATGCCCT GCGCATCCACCAAGATGTTATCACCTTTGAGATCCTGATATCGCTTATCAGCCCTGATCTATGTTCCCAA CAATCTACTCACTCGATGCCAAATATTCTTCGAATGCAAGTACGCTAACCCTTCTAGAATCTGTTCAGTA AAGAATCTGACGAGCTGCGGCTCGAAACGGGCTTGGTTAGGGGCGCGGTAAATTGAGGCAATGGTACCAC CGGGGACATATTCAAGGAAACTATGCGGATGTCAACAATTGCCGATGGGCTACGCTTGTTTATAAGCTGG ACCCACATGGACAAATACTCGGGGCTTGTCTCGTATCCTATTAAGGCGTCAGCGTCATGTAAAGCCTACG TCAAAACCAAAACAAAACAACTCACCCAAATACGCCACAATGTTCTTATGCTCTAAACCCTTCAGCAATT CGATTTCATCCCTCAACGCTTTGACCATCCCTTGCTGCCTTGAGTCATGCCTTTCAATTTCTGTCGCCGG CAATTCGACCTGTTTGACCGCCATCATATCTCCCGTTGTAACATTGAGCGCGATATACACCCTACCATAA GATCCTTTCCCGATAAGCTCGCCTTTGACCCAGTTCACAGTGCCAGGCTTGCCATCAGAGGCAGGTGATT CAGGGATATCGGCTTCGCGGTTGGCCTGAGCACGCGCGAACCTGGTAACTTCCACCAGCTTATGATCCCA CATGCTTGAGCTTCGTCTGTTGTCCTTCTTTCTCTGCTCCTCACTTCTGGGGTCGACAACTTGATCATCC ATGGCAGAGTTGACCTCTTCAGCACCGATGTCGTATTCTGGTGGAAGGTCTTCGTGTTGGGATATCTGAC GCTGAAGGGTGCGGCGTTTGTGATCGGCAACAACTCGAATCGACCGGCGATTCTCCGCTTTATTGAACTT TGATCTATTGAACGTTCCAGGAGGTCCCGAAGAAGGCCCTGGTGCTTGAGGCGCCCTACCCAAAGGTCCT GATCCGGCCTGGGGGCCACCTTGTCTACCAGGTGCTGCACCTGCGGGCAATGGTAGCCCACCGATGATCT CCACTCGACTCGGCGACTCAATCCCGGGTGTTGACGGTATCGACTCAGCTCCTTGCACAATGGGTCTATC CAAATCAATCTGCGGGAAAACCCTGTCGAGATTTTCATACAGTTGCTCGGGCTCCGGACGGAAGTTCCAT TGGTTGGGGTCTCTGGGGCGAGCAAAGGATTTGCCGCGCTTGATGTTGGACCCCTCAACCTCACCATCAC CTTCACCTGTGCCTTCAGACTCAGTTGCGCTATCTGGTGGCGTGCTCGCCGAAAGTACAGGGTTGACTTG ATGATACGCCTGCTGGCTCAAAGAAACAGTGTTGACGATGAGATTAGGTTTCGAAGGTGACGGGCGTATC GCGCTTGTGCGAGATGGAGACGTTTCTGGTGCCCGGACAGGCGGCGTGATAAACAGTGTTGCTTCATCTT CTTCTTCCTCCTTCCTTGGTCTCACGGTCCCTTCTCCGCTTCCTGGTCCCATTTTTGCAATCATCTCCTT CAAATGTCTGTCCCATTGCCCAGCCTTAGCCGTGTCTCCCGAGTTTGTGTCGTTGTCTTCACCCACGCCC TTTCCTGGCCGAACTGTCGCCTCGCTGCTGACTGTGCCAGCTACTGACAAAGTATCAGAGTCGCTCCGAT TAGCAACAGCCCTGGAAACTGATAACCACGAGGACTGTGGGCTTGCGTTATGAGCATAGGGCAACTGTGA GTCGGTGTCGTCAAATGCATTTGTCTCACTGATCCTAGGTTGTTCGACCGGGACAGGTGATGCAGTACGG TATGGAGTCGATGCGCTACCGCTTCCAGCTCGATCGGCCCAAGGGAATGGTGAAGATGGCCGACGAACAG CTGCACCATCTTCGAACATAGTGCGGGCATTGTCTGGAGGGTGAACTTCATCGTAATACGTAGAAGGTCG GCGAGGCGGAATTGTGGTTTCAGGTGAGGTGGGAGGAGGCGGAGAGCGGTCGTAATGGACAGTGTTGGGT CGTGTGATATCGAATGTTGGACCGCGAGCCGATCTTGGTACAGGATTAAACTGCTGCGGGTAGCCTCGCC AGGAATTCGAAGATGTCGCGCTGCTCGGGTGCGGTGACGGGAATGGGACAAGACCTGTGTCAATTATAGC TGGTGCCATGGGTGTCGCCCCCCTAGACGAGGAATGCAGGGGTTCCGGATATCTCCCATCTCTGGCTCTG TCCGATGATGGACTGCGATACGACGTGCTTGTGGCTGCAGGTTGAATATTGCGATGCTCTGCGAATCCTG GAGCAGGGGTGATTGATGTTCTGGGAGGCCCGTAAATCTGACTTTGACGTGAAGTCACACCAAGTGGCCC GCTGGTCATCCTCAAATTATCTACAGATCTAGCAGTGGACAGTGCAGGAGCTTGAAGACGCTCATTACTT GGTTCATGAGCAGCGTAGCTGAAAGGATGTCGAATTCGCTGAGATTCCGGGCGAGGGGTATTGGATGTCC GTCCGCGCTGCCCCGAAGCCGGTGCACGTCCCGTCGCCTGTTGCAATCGAGGGTCATGTAATCGCTCTTG AGCATGTGAGGTTTCAGCGTAAGAAGTATTGGGAAACCCAGATGGTCCGCGGTGAGAGTAGGCGAAATCC GGCAGATACTGTGACTGCGATGGCTGATAAATAGGCTGACTGCTTTGCCGTGGCGGTAGCGCTGGAGACT GAGTCTGATTGGTTCTCGGCGCCGATGTCTGCACCATGGGCACTCGTCCCTCTGAGGGCCTTCTTGAAGA AAGCGACCCTTCTGTTGAAGGGCTGACCATCCAAGTAGACTCCCATGTGGCCGAGTCATCCAAAGGAGCC CCCATCCTAGCTCTGTTCTGAAAGAACTGCTGCCTCTGACGCCTATCTTTCTCAAATGTATGAAATCGAC TTTCCTGTTGCTCTCGCTGCTCTCGCTGCTCTCGTTGTTCCCTTTGTTCCCGTTGCTCCGCCTCCCATGC CGTACGGGCTGCTTCTAGTGCTTGCCTTTGCTCTTCTTCGTGTCTCTGCTCCTCCTCTACCTGCCTCTAC ATTGGTCTTCAATACCGAATCGAAACATATATAGATACTACTCACAGCTCTGGCTTCATCTTCCGCGATT TGCGCTTGTTCTCTTTGCCTCTGCTCCTTTTGCATTTGCTGCATCATCTCCCACAGTTCTCTTTCGCTCT GCTGCTCTCTCTTTGCCAACTCTTCATCTGCTTCGAGTTGCCTTCTTCTCTCTTCCTCCTTCTTTTGCGC CTCCTGTTCCTCCCTTTGGAATTGCTCTATCAATGCGCGAGTCTCTGGGTCAATGTCATCATCCAAAGTA AGCCCGAGTCCTTGGCTGCCTTGCTCTTGACTCATTGCTGGATGGCTAGGACCGGAAAATGCGTTTTCGT TTTGATATGAGTCATTTATTGGTGTTCCAGAACGAGGAAAGACAGAGGTAGCATTGGAAGGCTTGAAGTG ATCGAATTGCGGAGGTAAAGAGAGTTCGTTAAATTCGTAATGTCTGCTAGACGGTCGACTAGACGGGGAA GAACGAATGGAAGGTTCGCCAGCCTGTAATGAGGTGGAATGAGGAGGTATAGGTGGTGTGGGCAAAGCTG GAGAGCTCGTACCCAAAGAAGCCGAGTGTTCTGTAACAGGTGATCTCGATCCACCCGTTGAAGTCGATAG TCGCACACCCGCATTCTGTAACACAGATTTCCTTGTGCTCCTTGACAAACCGGGCGCTGACCAGTCCTCT GCTTCATGTCCTAAATCACTCCAGTCACTGGCACTAAGCTCCCCCCGATTGAGCATTTCTCCGCTGGCAC TACTTACACTACCTTCTTTTGAATGACGACTTGAGACACGGTAAAGTACTGGATTAGACAAATCCGTCGT TATTGGGGGAATCCCTGCACGTCGGGGGTCCGCCGCCGCGCGAAAAGGATGATAATCGGTTTGAGAGACG GGTGGAATGACAGATGCGGCGGACGACGGTGGAACATCGGTTTGCTTGACTAGGAATTTGAGGCTAGCTC GAGAGTCTCCCAGGGTGCGGCAAATGTTGAGAAGTGCAGCAGGTAATATAGGTGTTTCATCTGCCGGTTC TCCAATTTCGGTACGATACATCGACAGAGTTGGGTAATCTTCATCTCTAATACGCAGCTATGAACAATGT CAGCTATGTCTAACGGGTATAAACAGAACTTACTTTTGAGAATACTTTCTCACGTATACCTTCAGCAGTA TTTATCCCTGTAATATCTACCAGATGAAACGCTTCGTTATCAGTCGTCACTTGCAGTCTGACCTGTTGTC CTTGCACTGAACCCGACCGATTTCTGTGCCCTATTCCCACACTCATGATGCTCCCATGTTCGCTGCCAAT GGCAGGGCTTATCACATCGTCGGGACTTGCCACTCTTGTTGGATTATGGGGATGATACGCAGGAGGAGCA GAAAATGGTTGCCCATGCGCGGTTGACGGGGATTGGGAAACGGGGGAAGGCATTGTAGACTGCCGAGTGA TGGGTGATGGTAATGGGGGAAGAGCACGCGATGGAGAGTTGGGAACTTGTTGGTGGAATGATGTTGCACC TGTGCTTGAAGGATGAGGTTCTGGGAAGAGTCGAGGTGTATGTTCCGGAGTTGGTGTTGTAAACGCCCGT TGAAGATGCCGCTGCGGTTGAGGGGGCGGTTGTGGTGGTCCTGACGATATCTCTGGAGTGTGACCATATG CTGTTGGCGCAGGCGATGGCGTTGGTACCAACGGCTGTGGACTTGGGAACGCCGATATAGAGGGTAAAGG GGAAGATTGAGGTGCAGGAATTGAAGGATAAGGCAAGCCCCCTCGTTCTTTGATACTATGGGATGGTGAT GCTGGCTGAGGGATGGATACTGAACTGGGACCACCTCTCCCGGAGCTCGATGAGACACTGATAGGTGATA CTGCTGACGGTGATTTTTGACTCCCAGCTTTGGGCGGAGAGTTTTCCTCATCAGAGTTGTCTGGGTTTGC GATGAATAGTCCAGGCATAACACCGCGCCGACGCGCACCTTGAGGACGACGAGGGAGCGTCGGAGTGGAT GGCCCAGCACCGGCAGACCCAGTCGAAACTGAGAGCTGCGGGTGATGAGACATCTCGAGGTTATGCGGAA AAGGGTTACTTGTGGGTTGACCAGATTATGTGGAAGTAGGAATACAATTATGGTGGTGAAAAGGTGAATG GCCGCGAGAGGGATGACGAAGAAAAAGTCTGCGTGGGGAAGACAAAGGTGGGTTGATAATCGCACGAGTT CGGAAGCGCGAAGGTGGGGGTTGTTGTCAGCTCAAATCTACGCATTTCGGCAGCTTTCTTGATCTATGGC GCCGTGGACAGTGGGCAGAATATCGACTCACAGCACTTGGCTCTCTATTTCATCTCTCCTGCTGGCTTAT TCGCTGTCCAGTTTTTCTTGTCTCGGCCGCGATTGTCAGTAGTGGCGTGCCAAGCCGGCATGGGACGGCA GGAATGAAGGAGGTAAAGAATGTTATGGAGATGAAATATGTACGGAAGACATGCATGTA
Protein Sequence	>gi\|799340830\|ref\|XP_012052184.1\| STE/STE11/BCK1 protein kinase [Cryptococcus neoformans var. grubii H99] MSHHPQLSVSTGSAGAGPSTPTLPRRPQGARRRGVMPGLFIANPDNSDEENSPPKAGSQKSPSAVSPISV SSSSGRGGPSSVSIPQPASPSHSIKERGGLPYPSIPAPQSSPLPSISAFPSPQPLVPTPSPAPTAYGHTP EISSGPPQPPPQPQRHLQRAFTTPTPEHTPRLFPEPHPSSTGATSFHQQVPNSPSRALPPLPSPITRQST MPSPVSQSPSTAHGQPFSAPPAYHPHNPTRVASPDDVISPAIGSEHGSIMSVGIGHRNRSGSVQGQQVRL QVTTDNEAFHLVDITGINTAEGIREKVFSKLRIRDEDYPTLSMYRTEIGEPADETPILPAALLNICRTLG DSRASLKFLVKQTDVPPSSAASVIPPVSQTDYHPFRAAADPRRAGIPPITTDLSNPVLYRVSSRHSKEGS VSSASGEMLNRGELSASDWSDLGHEAEDWSAPGLSRSTRKSVLQNAGVRLSTSTGGSRSPVTEHSASLGT SSPALPTPPIPPHSTSLQAGEPSIRSSPSSRPSSRHYEFNELSLPPQFDHFKPSNATSVFPRSGTPINDS YQNENAFSGPSHPAMSQEQGSQGLGLTLDDDIDPETRALIEQFQREEQEAQKKEEERRRQLEADEELAKR EQQSERELWEMMQQMQKEQRQREQAQIAEDEARARQVEEEQRHEEEQRQALEAARTAWEAEQREQREQRE QREQREQQESRFHTFEKDRRQRQQFFQNRARMGAPLDDSATWESTWMVSPSTEGSLSSRRPSEGRVPMVQ TSAPRTNQTQSPALPPRQSSQPIYQPSQSQYLPDFAYSHRGPSGFPNTSYAETSHAQERLHDPRLQQATG RAPASGQRGRTSNTPRPESQRIRHPFSYAAHEPSNERLQAPALSTARSVDNLRMTSGPLGVTSRQSQIYG PPRTSITPAPGFAEHRNIQPAATSTSYRSPSSDRARDGRYPEPLHSSSRGATPMAPAIIDTGLVPFPSPH PSSATSSNSWRGYPQQFNPVPRSARGPTFDITRPNTVHYDRSPPPPTSPETTIPPRRPSTYYDEVHPPDN ARTMFEDGAAVRRPSSPFPWADRAGSGSASTPYRTASPVPVEQPRISETNAFDDTDSQLPYAHNASPQSS WLSVSRAVANRSDSDTLSVAGTVSSEATVRPGKGVGEDNDTNSGDTAKAGQWDRHLKEMIAKMGPGSGEG TVRPRKEEEEDEATLFITPPVRAPETSPSRTSAIRPSPSKPNLIVNTVSLSQQAYHQVNPVLSASTPPDS ATESEGTGEGDGEVEGSNIKRGKSFARPRDPNQWNFRPEPEQLYENLDRVFPQIDLDRPIVQGAESIPST PGIESPSRVEIIGGLPLPAGAAPGRQGGPQAGSGPLGRAPQAPGPSSGPPGTFNRSKFNKAENRRSIRVV ADHKRRTLQRQISQHEDLPPEYDIGAEEVNSAMDDQVVDPRSEEQRKKDNRRSSSMWDHKLVEVTRFARA QANREADIPESPASDGKPGTVNWVKGELIGKGSYGRVYIALNVTTGDMMAVKQVELPATEIERHDSRQQG MVKALRDEIELLKGLEHKNIVAYLGYETSPEYLSIFLEYVPGGTIASIYRAPNQARFEPQLVRFFTEQIL EGLAYLHSKNIWHRDLKGDNILVDAQGICKISDFGISKQTADAYDSFGQATNMKGSVFWMAPEVIHSYSE RSYSGKVDIWSLGCVVLEMWSGKRPWGDMEQFAAMFELFNKRSRPPLPPDINLSSVALDFLNEKCLATDP RSRPMARDLLQHEFIKDRDLTWTFKDSKIGKAVAKRGAKRPKA
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: bck1 mutant had defects in cell wall integrity and high temperature endurance (Gerik et al., 2005).
References	*Gerik et al., 2005:* Gerik KJ, Donlin MJ, Soto CE, Banks AM, Banks IR, Maligie MA, Selitrennikoff CP, Lodge JK. Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans. Molecular microbiology. 2005; 58(2); 393-408. [PubMed: 16194228 ].


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BCK1