Victors

URE2
Victor ID	5269
Gene Name	URE2
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23888844
NCBI Protein GI	799347829
Locus Tag	CNAG_05540
Genbank Accession	CP003833
Protein Accession	XP_012053644
Taxonomy ID	235443
Chromosome No	14
Gene Starting Position	596590
Gene Ending Position	600483
Gene Strand (Orientation)	-
Protein pI	5.91
Protein Weight	89554.72
Protein Length	881
DNA Sequence	>gi\|799350995:596590-600483 Cryptococcus neoformans var. grubii H99 chromosome 14, complete sequence ACTTTATTCAATATCATGTTTGTACATTAGCATCCATCTACATTACGAGTTCAGCATCTGGACCAATCGG TTTTGGGAGTAAAAGCATGTATCGATAGTTAGGTTAAAGGTATGATGCTTTAAAATTCAACGGCAGGCCG TCTGCCCTCACCACCTGTCATGACGGATTCTATGTTTTGGTTTTAGATTCTGGGTTGACTCAAGTCATTC AATCTGATACCTGAAAAAAGGCCTTTAGGGGTTCCTGTTTGAACTGTCGGTTGCAGGACAAAAAATGGCA GTCCAAATTTATTCCGAAGTACTCACTTATGATCTGCAACAAAATTGGCAATGTCAACGAGTGAAATTGT GAACGGTCTTTTTGACCTATCAGATCCTAGCCAAGGGCCAAAATTCATCGATTCATCTCCGTTGACCATT TGTACAATTTCATAACTTATCCTTGAGACTCCATTGGAAGATAACTAGAGGTTTATTAGAGATTTATTAA ATATATATACAGTTGTTCATGAATAATGGAGAAATGCACTGATACTTAGTAAACGAAGTATCTCCTGGTC AATGGGAGTTTGTCCGCGGGTGGGACGTCGCAAAGGACTCCGTCGGCGCGCACGTCGTAGGTCTCCGGAT CGACTAAATGGAGCTTGAGTAAGTGACTCGTTCACACAGTGGTTACTGTCACTCACCAGTCATCTTTGGC ATAGTGTCGTTCCACTTCATATCCTTCTTTCCAATCGAACGGCAGTTCTTGACAGCCTCTGCCCTCTTCT TAATGTTGAATCTCTTAACGAGGTCTAACAATCCATCAGCCATACCCATTTGTAGACAGCAGAAAAAAAA ACGAAGACCCACCCTTGTCAAGAGATGCCTGGCTGACCCAAACAATTGAATTGAGTGCAGCGGCCTCAGG CTGAGAGCCCCACATGGGCCTGCCAAGGACGGGCTGCACAGTGGGGATCGAAGCGTTCGCATCGCCCACC GCAGCCCAAGCAATAACACCGCCCTTGAGGATCATCTCCGGTCTAGCACCAAAGGACTCTGCCGTCCAGA AGACCAGATCTGCCAAACAGCCCACAGCAACTTGACCGATGAGGTGCGACATACCGTGGGTGATGGCGGG GTTGATAGTGTACTTGGCAACATATCGCTTCACCCTGTTGTTGTCTCTCGTGGGCTCATCGCCCTCAAGC GGACCACGGAATTGCTTCATCTTCGCAGCCGTACGCCATGTACGAGTGACGACTTCACCGATACGACCCA TAGCTTGACAGTCAGATGAGATCATGGAGATCGCGCCTGTGTCCTGTAAAACATCTTCGGCTGCAACGGT TTCAGAACGGATACGAGAGTCGGCAAAGGCAATGTCCTCCGGGATGGACTTATCAAGGCCGTGACAGATC ATAAGCATCTGACCTGTCATTAGCATTGCATTGAAACATTGCTCGAAGAAAAAGGACCCACGTCAAGATG TTCATCAAGAGTGTTAACAGCATAAGGCCTAGTTGGGTTAGTGGAACTAGGCAAGACGTTTTCATATTCA CAGACAACGATGATGTCTGGAGCATGTCCGCCACCAGCTCCTTCAGTGTGGTAACTGTGAATGGTCCTAC CTTTGATGGCGGCCAAGGTACTCTCGACGTATCCACTTTCGTTAAGAGTATCGCTATGGAGGTTGATCTA CAGTCGAGTAGTTATTATCACTATGCAAAGACATAGCCAGGCGGATAGGCAACTCACCTGTACGTCGTAC TCGTCGGCCATACTCAGAGCCCTGTCAATGACTTCTGGCGTCGCGCCCCAATCCTCATGCACCTTCAATC CACACGCTCCGGCCTCGATAATGTCCCTCATAGCATTTGTGCCAGAATCGCTGCCCTTCCCGGTGAAGCC AAAGTTAAGAGGAATAGTGTCGGTTGCTTTGATCATGTTTTGCATGTAAAAGGACGAAGACGTGCAGGTG GTGGCGTTAGAACCGTCTGCAGGACCTGTACCACCTCCAATAACCGTGGTGATACCGGATGCCAAGGCCT TGACAATTGAATCAATTGCTGATCCCCATCCTACTAGAGAAACTTACCTCAGTCATGAGTTGAGGAGAAA TGTAATGAACGTGGACGTCGAGAGCTCCCGCTGTGGTGATCAACTTTTCGCCAGAGATAACTTCAGTGCT TGACCCCACGATCATCCCATCTGTGACTCCATCCATCATATCGGGGTTACCAGCTTTACCAATACCAACA ATAATGCCATTTTTCACACCAATATCGGCCTAAAGAGACGTTAGCGACACAGAGCAGACAGTTGGGCCTG TTGCAATCACCTTGTAGATGCCAGTCCAGTCAACGATAAGGGCATTGGTAATAACGAGGTCAAGGACCTC ATGATCATGCCTACCAGATGCTTGACCTCCGCCATCTCGAATGACCTTACCTATACCGGATGTCAATTCA AAAGCCAAAGACAGATTACTGATCACTCACCTCCACCGAATTTGCATTCATCGCCGTAGACAGTGTAATC TTTTTCGACCTCGATCCACAGATCCATGTCAGCGAGTTTGATCTTATCGCCAGTTGTTGGTCCGAACATG GAAGCGTACTACGATAAAAGTTAACGACGTCCGACTATTTCAAATGGGTCACACGAGACATACCACTTCC CTGTTCATTTCAGTTACCGGTCCCTCTTCTATCTTTTCTTGTTCCTTATGACCGAATCCACCTTTCTCAA CCATCTCCTTAACTTTAGTTTCCCTTAAATTCTCGTCGAAAGATCCGTTTCCCAATCCACTTCCACCGTG GAAGATCTTCTTTCCGCCGAATTCCACCATTGTTACAGTCTTCTTCTCCCCGGGCTCAAACCTGACCGCC GTACCAGCGGGGATGTCCAAATGGTAGCCATAGGACAAGAGTCTGTCGAAGATGAGAGCCGGGTTGGTTT CGAGGAAATGGTAGTGGGAGCCAACTTGAACGGGCCTGTCTCCAGCATTCTTGACTTCAAGCCTAAAGCG TCGTCGGGAAGCATTGATTTTAACTGTCTCCTTGCGACAAATAAGTGCTCCTAAGAGGGTATCGGCTGGC TCGGGTGCAGCAGGGAAGACGTCTGCCGAAGGGATTGGCAGGAAAGAACCGTAAAAGGCATTGTTCACTG TTTTCATAATAGTTAGCATTTGGTGATGTATTTTGAATGCTTCAGACTAACAGTCGCCATCATCTGAGGA GATGGGATCATCGACTGTGACCAAAAATACACCATCGGGGAAAGTGCCTTCCACCTGAATAGTGTGAATT GATTCTGGAACACCTTTCCTGACGTGTCGCCTGCCCAGCATCTTCTTCCCTAAATCCATGAGCTCTGCGA CAGAGTGGCGTCCATCTCGAACGAATTCCTGCAGCTGCGAGGAGATGAGAGCAATAGTCTCAGCACGGTT AAGAATAAGGCCTCGGGCAAGACGACGTTGAGCAAGGGTGCCCAAGGTGGTGAGGATGAGTTTGTCCTGA GTGGTAGTCAGTCAGCTTGTAGTGTGGTGCTGGGAGTGGAGGACTTGCCGTTTCTCTCGGGAGGAGATGC ATGATGTTCTTGGTGTGGTGAGGAGGAAGAAAGGGAAAGCAAAAAATAAAAAAGAGGAGCAAGGAATCAA AAACGGGACGGAGGGGATGTGGGAGCTGCGTGCCTTTGTGGGGCTAATAATGACGATACGAGCCATCCAG ACAATCCAATCAGCTATCAGCCCAGGCACCCGTTATCCTCGCGTCTCTTATCAGCAGACACTCACCTATA CGTACCTTAGTTTCCCATCCGGTTCCATCCGTGCTCATGTATCCGGGCTCGTGTATCCGTGCTCGTGTCC TCCCATCCAAGCAACTGTGTGTTTGATGGCCTTCCCATAAGGAA
Protein Sequence	>gi\|799347829\|ref\|XP_012053644.1\| urease [Cryptococcus neoformans var. grubii H99] MSTDGTGWETKPHKGTQLPHPLRPVFDSLLLFFIFCFPFLPPHHTKNIMHLLPRETDKLILTTLGTLAQR RLARGLILNRAETIALISSQLQEFVRDGRHSVAELMDLGKKMLGRRHVRKGVPESIHTIQVEGTFPDGVF LVTVDDPISSDDGDLNNAFYGSFLPIPSADVFPAAPEPADTLLGALICRKETVKINASRRRFRLEVKNAG DRPVQVGSHYHFLETNPALIFDRLLSYGYHLDIPAGTAVRFEPGEKKTVTMVEFGGKKIFHGGSGLGNGS FDENLRETKVKEMVEKGGFGHKEQEKIEEGPVTEMNREVYASMFGPTTGDKIKLADMDLWIEVEKDYTVY GDECKFGGGKVIRDGGGQASGRHDHEVLDLVITNALIVDWTGIYKADIGVKNGIIVGIGKAGNPDMMDGV TDGMIVGSSTEVISGEKLITTAGALDVHVHYISPQLMTEALASGITTVIGGGTGPADGSNATTCTSSSFY MQNMIKATDTIPLNFGFTGKGSDSGTNAMRDIIEAGACGLKVHEDWGATPEVIDRALSMADEYDVQINLH SDTLNESGYVESTLAAIKGRTIHSYHTEGAGGGHAPDIIVVCEYENVLPSSTNPTRPYAVNTLDEHLDML MICHGLDKSIPEDIAFADSRIRSETVAAEDVLQDTGAISMISSDCQAMGRIGEVVTRTWRTAAKMKQFRG PLEGDEPTRDNNRVKRYVAKYTINPAITHGMSHLIGQVAVGCLADLVFWTAESFGARPEMILKGGVIAWA AVGDANASIPTVQPVLGRPMWGSQPEAAALNSIVWVSQASLDKDLVKRFNIKKRAEAVKNCRSIGKKDMK WNDTMPKMTVDPETYDVRADGVLCDVPPADKLPLTRRYFVY
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: URE2 gene product is involved in the utilization of urea by the organism. The mutant had reduced virulence in mouse infection models (Varma et al., 2006).
References	*Varma et al., 2006:* Varma A, Wu S, Guo N, Liao W, Lu G, Li A, Hu Y, Bulmer G, Kwon-Chung KJ. Identification of a novel gene, URE2, that functionally complements a urease-negative clinical strain of Cryptococcus neoformans. Microbiology (Reading, England). 2006; 152(Pt 12); 3723-3731. [PubMed: 17159224].


Search: for Help

URE2