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ARG1

Victor ID 5267
Gene Name ARG1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23889694
NCBI Protein GI 799347129
Locus Tag CNAG_06500
Genbank Accession CP003832
Protein Accession XP_012053527
Taxonomy ID 235443
Chromosome No 13
Gene Starting Position 681340
Gene Ending Position 683215
Gene Strand (Orientation) +
Protein pI 4.29
Protein Weight 44814.82
Protein Length 435
DNA Sequence 
>gi|799350950:681340-683215 Cryptococcus neoformans var. grubii H99 chromosome 13, complete sequence
CCGTTAGTCCAGTACATCTAGGCACCGCATAAACAAACCCCGTAAAAAATAGGTGGGTTACGTAACATCC
CTACACCTCCTTTCAAACAGTCCACCGCAGTCCTCTCCAGTGTACACTGCATGCTAGCCCACAATGGACC
TGCCCCTCACCCTCGACGACCACATCCCATTCTCCCACCAGGTTGCAGGCCACCCCGGTGTCATGTCGGA
TCCCTCCGGCAGCCTCGTCATCAAGCCCGCCCTCCCTCGCGAAATCGCCTTTTATCAGCTGCTGTCCAAC
TCGGATCCGGAGGATATAGTGTGGCCGCTGAGGAAGTTTGTACCGAAGAATTATGGCACACTGAGGCTGG
AAGGGAGGATAGGTGCGGCGGGTGGGGTTGAAACGGATTTAGATGTGCAGGATGAGGTGCCAGAGGTGTG
TGTGTCTGTGTTCCGATACGTAAATTGACTAGACAGCCGGCTGATCACCTTCGGGATAGAGCGTGGTACT
AGCAAATCTTGCTTATGCGTACACTCGTCCGAACATTATGGACGTCAAACTCGGTACTGTGCTGTACGCT
CCCTACGCTACAGACGAAAAGAGACAACGGATGGATCGACAGGCGAGGGAGACGACGACGTATGAGACGG
GGATACGCTTAACAGGCTGCCAGGTGACTCTATCTCCATCTCTGCTCAAAAAAAGGGGCGGGACTAATGT
TAAACTGGAAAACCTAGACATGGCACGCCCCTACACAAAGCTACATCTCTACACCCAAATCATTCGGCAA
ATCTATCACGCCTCCCCAACTCTCTCAGGGCATGGTCCGTTTCTTCCCTCTTCCAACCGACTCTATCCCT
TCCCTTGTCACTCTTCCTTCCCCACCTCCTACAGCTGTAGAGGTCGTTTCTACCGTTGCGGCGAGCCAAT
TACCAATACCGGCCCAGACGTCTTGTGCTTCCGTTATCCAATCTTCCACTTCCATTCCCATTCCCCCTTC
TACTCCCATCTCCCCCGACCCTGCCGCTATCGCCAGCATTTTCCCCGCCTCCACCGACCCCGAAAACTCA
CCAACGTACGAAAACCACTCCATCCCCCCTCCTACCCTCGCTCGTCTCTTAACCCTCCTCCTCCAAAAGC
TCGACCAACTCACAGCCGTGCTTTCCACCCTTGAAATGCGATTTGTGGGTGCTTCGCTGTTGGTGGTATA
TGAAGGTGATCCGATAAGGCTCGAAGCGGCGCTGGATAGGGAGGAAGCGAAAGTGCAGGAAGAGAGTGAA
GAGAAGGAGAAGAGAGATGGGGAGAGGTCAATGTTTAGTGATGATGGGTCGATCGACTTTTCAGACTCGG
ACGCGGACTCGGACGAGGATGATGAAGAAGAATATGACTCGGATGACGAGTTGGATGGAAAGAAGAAGGA
CGAAAGACGAGCGAGCAAATGTCCGGCGTTAACACTAAAACTGATCGATTTCGCGCATACCTGGTTAGCA
CAGGGGGAGGGACCGGATGAAGGGGTGTTGAAAGGGTTGAAGACGTTTAGGAGTCTGGTGGAAGGACGGT
TGGAAGAGGTTGAACGGGGTTGTGTTTGAATAGGACTCTTGCCATGGGTAAATTCATAGCCAATTGTAAA
ATAAGGAATAAAAGAAAAATGTGCATCCTACCATCCATTATGTATCGAGATCGGTGGAAGGTAGGGAGGG
AGAGGTGGGCTGAGATGGAAATGGCTCCATTCGATGCCGGTAGAGAGGAGTTTGTATCCTTCGTTTTGTC
GAATTTTTGGGATGACGAAGATGGTATGGCCATGGCGAGTTGGTACAATCCAAAAGTTGAAATAAGTAAA
GCAAGCCAAACCGAGAACGGAGGAATGAACAGCCAAAGGAACATGAGGGGTTTTGC
Protein Sequence 
>gi|799347129|ref|XP_012053527.1| arginine metabolism transcriptional control protein [Cryptococcus neoformans var. grubii H99]
MDLPLTLDDHIPFSHQVAGHPGVMSDPSGSLVIKPALPREIAFYQLLSNSDPEDIVWPLRKFVPKNYGTL
RLEGRIGAAGGVETDLDVQDEVPESVVLANLAYAYTRPNIMDVKLGTVLYAPYATDEKRQRMDRQARETT
TYETGIRLTGCQTWHAPTQSYISTPKSFGKSITPPQLSQGMVRFFPLPTDSIPSLVTLPSPPPTAVEVVS
TVAASQLPIPAQTSCASVIQSSTSIPIPPSTPISPDPAAIASIFPASTDPENSPTYENHSIPPPTLARLL
TLLLQKLDQLTAVLSTLEMRFVGASLLVVYEGDPIRLEAALDREEAKVQEESEEKEKRDGERSMFSDDGS
IDFSDSDADSDEDDEEEYDSDDELDGKKKDERRASKCPALTLKLIDFAHTWLAQGEGPDEGVLKGLKTFR
SLVEGRLEEVERGCV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Ãˇâ€¯arg1 mutants had impaired thermotolerance, compromised cell walls, reduced capsule production and melanization, defective cell separation, and the inability to form mating filaments and attenuated homeostasis and virulence in the Galleria mellonella infection model (Lev et al., 2013).
References
Lev et al., 2013: Lev S, Desmarini D, Li C, Chayakulkeeree M, Traven A, Sorrell TC, Djordjevic JT. Phospholipase C of Cryptococcus neoformans regulates homeostasis and virulence by providing inositol trisphosphate as a substrate for Arg1 kinase. Infection and immunity. 2013; 81(4); 1245-1255. [PubMed: 23381992].