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APP1

Victor ID 5266
Gene Name APP1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23889762
NCBI Protein GI 799334003
Locus Tag CNAG_06574
Genbank Accession CP003826
Protein Accession XP_012050708
Taxonomy ID 235443
Chromosome No 7
Gene Starting Position 162954
Gene Ending Position 164008
Gene Strand (Orientation) -
Protein pI 4.71
Protein Weight 19160.47
Protein Length 181
DNA Sequence 
>gi|799350762:162954-164008 Cryptococcus neoformans var. grubii H99 chromosome 7, complete sequence
AGTTTGCTTATACGATGCTTTATCATGGGTTAATAGATTTTTATGTATGCAGCGATTACTGCTATTGCTA
ATAGGACACCACAGTACAAGTGCTATAAGAGTACATCGCAAACTACTGCTGTGAACAAAATAGACCCATT
GAATAGTACAGAGATATACGACACACAACGACAGACAAGGAGAAAGGAAAGGAGCGCAAAATATCACTTG
CGATCAGCTCAAATCATCAATGTTCGCAGCTCCTTCAATGTGATGGATGCCACACCAGCTCTCCAGTCCC
CTGCCCAACGAAGTTCACAGGCCTCTAGACACCCTATAACCCTTGCGAGCTCCATCATTTGCTTATCATT
TTGCAGCGTTTCGGCTGCCTGCAGGCCAAGTATAACTGATTGGGCCCATCTAATGCTGCTTTCCCCATTC
ACATGGTCGAGTCGACCGAGAGCAGCCTCAATGACGATCTTATGGTTTGAGACTTTGGTTTGTGGTTTGT
AGGTTTTCAGAGCGGCCATCTCGCAAGTCATGTTGCAAAGTTGTACCTCGGGTTCCTCCTGGATGAACAG
AATCAGGATTGTATCTGAAGTAAACGTAGTCTTCTTGAATGGATGGCTTACCAACTCATCGTCGTCATCA
GTATATACCTTCTTCTCGTAATCTTTGCTTGCGGCCATAGTGCTGAGTAACGCAGTTTGGACTTCAATAT
GATTCTCGATTCTGGTTAGCCTTTCTAAGATCTCGGGTCTCTGTTAAGTATAGTCAGTTTCCACTGATAG
GTCATCGAATGTATAGCTGAAAGTGAATGTAAAAGGTCTACTACTGACGGTGACCGACTTCGTCGTCCCC
TTGGGAAGCATTTCAACACAGTTGGCACAGTCAAAGCAAAGTTCAGCAGTGGCAGAGGACATCATGTATT
ATTTGTTGGGTTGGCTTACAGATAACTCAACGGAAGAATGTAATGCCTGGGAAAAGATGCTTTTATATCT
GGAACAGGTCATGAGACAAGATGCCAGATGGCGCGCGCGATTAGAAAGTACGACTTTTGACGTCATGACA
GGTGA
Protein Sequence 
>gi|799334003|ref|XP_012050708.1| antiphagocytic protein 1 [Cryptococcus neoformans var. grubii H99]
MMSSATAELCFDCANCVEMLPKGTTKSVTRPEILERLTRIENHIEVQTALLSTMAASKDYEKKVYTDDDD
ELEEPEVQLCNMTCEMAALKTYKPQTKVSNHKIVIEAALGRLDHVNGESSIRWAQSVILGLQAAETLQND
KQMMELARVIGCLEACELRWAGDWRAGVASITLKELRTLMI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The ̉app1 mutant strain showed a decreased virulence in mice deficient for complement C5 (A/Jcr), but it was hypervirulent in mice deficient for T and NK cells (Tg̵26) (Luberto et al., 2003).
References
Luberto et al., 2003: Luberto C, Martinez-Mariño B, Taraskiewicz D, Bolaños B, Chitano P, Toffaletti DL, Cox GM, Perfect JR, Hannun YA, Balish E, Del Poeta M. Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. The Journal of clinical investigation. 2003; 112(7); 1080-1094. [PubMed: 14523045].