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APH1(Cryptococcus neoformans var. grubii serotype A)

Victor ID 5265
Gene Name APH1(Cryptococcus neoformans var. grubii serotype A)
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886492
NCBI Protein GI 799322149
Locus Tag CNAG_02944
Genbank Accession CP003822
Protein Accession XP_012048240
Taxonomy ID 235443
Chromosome No 3
Gene Starting Position 377609
Gene Ending Position 380446
Gene Strand (Orientation) -
Protein pI 4.2
Protein Weight 55486.42
Protein Length 551
DNA Sequence 
>gi|799350639:377609-380446 Cryptococcus neoformans var. grubii H99 chromosome 3, complete sequence
TGAAGAGACCAATTTCATTATTATATGCATGTAGACACTTCCCTATATACCCATTCTCTATTTGCAATCT
AGAATTACTTTTGTTTTTCCCTTCAAATAAATACTCAGAAATTATACTATCCTTTTTTGATGCCCCGTTT
CCAGAATATATTCTCTCGGACTTTTTGATCCTCCTCTGTTTCGGATCTTCACCTGCCATCTCTTCAACCC
CTGTTATGACTGAATTTCCATTTCCACCTGCGTCCTTCCATCTTCCTCCCAACCTTCTGGTGTTGTGGTA
TGATAGTTTGACCCTTATGCTCGAGGAGCACGCCCATTATAATCATGTCCAGCCTCAACAGTGCTAATTT
TCCCCCGTAACCCATCAGCCAAAAAAAAAAGAATCTGGGCTGGTATAATAAGCAAAAGGAAATCAGCCAC
TTACTAGTCTCCATGACAGTCATAGTCATAGTCGATTTCAGCGATACGTTTCTGAAGAGCAGCAACGACC
GTGTCGAAAGCGCACATCCCGTCCTTGTTCCATCCGCACCCTTCGTAACTCTTGTCGAGAGGGAGAACAG
CATCGTTACTGGATTAAGTGAGGGGGGGGGTTTGAACAGTCAGCTTTTGTAACAAGACGAGACGAAAAGG
GAATAGTAGCTAAAAAAAATAAAAATAAAACACTCACATCATGAATCGCATCTGCTTGCTAGGCGTCTGG
TCCGCACACTCAAGAACTTGAACAACCATGTGCGTAGCAAAAGGCACCACCTGCGAAGCCACAAACGAAG
ACCCTTCCGCACGCTTGTCGACAGGCAATGGGCCCGTACTGAAAAGCGCACTCAAGTTGAAGGCGGTAAA
CGTATCGAGTAAGACAACTTCATGCGTCGCATCCGCATAGATGGATTGGTTGAGTGGGAAGTAGGTCGAG
TTGCTGTCGAGGTTGGTGTTCACGCTAGAGTTGGAAGAAGTGATAGGCGTCTGGGTGAAACGGGCGACAA
ACTCTTCGAGGAAGCCTTTACCTTGCGCAGCCGCCACGGGGGAACCGGCACCATTGTTGTAGTAAAAGTT
GAGATCGAAATAGTACTCATAGTTTTTGAAATCTTCCTCGGTGAAGACGCCGCAGAACGCAGAGTAGCCG
AGCGCATCAGTCTCATAAGAGCATAGCTGGAGCATAGCAAGGACATCGGTTGTGTCAAACTCGACACCGT
TAATGTAGCTTTGGAGTCGGGAGACGGTACCGTTGAAAGCGTCCGTGGCGAATGAAGAAGCAGCAGTTGA
ACCGAGGGAACCGCGGGAGGCAATGTTGGAGTTGGGACACGTTTCGTATGGTGCACCCGTGTTGTTCACG
CCACTTGTCTCCACCATGAGCTCAATGCTGACTTGGTCGAGGTACTCGGGGACTCCAAAGAAGCCAGCAG
CAAAGTTTTCGGCCGTCTTGACCATACGATCCTGTTAGAAAAAATTGTCAGCTATCCGTGTACCACCTTC
ACCTCGTTTAAGTAAGGGGCCGAAAACTTACTTGACTCTCAGTTCTGAATACAGGCAAAGCACCCTGCTC
CGTAAAGTTGTTCAACAACTCTCCATACTGCTGTCGGAAAGTCACTCCAAGCTCAAAGTTTTGTAACCTT
CCAAAAGGAGTCAACAGCTCAGCGCCAAGCTTATAAGTCCACTTGTTGAGGAAGTCGAGATCACCTTTGG
CAGTGAAACCCCCATCCTGCGCGGTAGCATCGGCAAGCTTGGCTGCAAAAGTGGATGGACCTGCGCCCGA
GGTGGGGTATCGGGCACCATGTCGGTATAGCAAATGTACTTGGGTAATGGAGCAGCTGTCAGGGATGAGA
GGAGAAGTATCGTTGAGGCCGTAAAAGCTGGAAGGGACAGAGTACCAAGGAGAGAGGTTACCCCAGTACT
TGAACACGTCAAAGCCTTCAGAGCCGTTGCCCGTGGGCTGATCGGCGACAAGAGGGAAACTGTTAGATGT
GCCATCGTTGTAAGCGTAGGCGGCAGCGGTAACCGCAGCAGCAGGCTCAGCACCAGTCACAGTCGCTCCA
GGGTAGCCAACGACAGATTCAGCAGGGAAGAGCTTGGAGTTAACGCTGGCTACAAGTTTGGTGTCAGCTA
GTTAATTACTTCTACCTCGAGAGTCCCAACAAACAGCAAGAAGATGCAACTTACTGCCAGCTGGAGGAAA
GACATCCGAGGTGGTTGATCCGACGTTGGAGTCGGCAGTGCGTCTCTCCACAGCAGCAGCGTTGGCGAGA
ATAGGGAGCAAGGCAAAGAGAGCTGCAGATCGCATTTTTGAGGGGAGTAATAAGGTCGGTTGACGGTGTT
TTTGGGTGAGTGGGTTCCGAATCTCTCTTCATCTCACAGCAACCTTATATACTCAACTGCGACGCTTTCC
TCTTTATACGTAGCATAGGCTGGCACACCTTGTGATCCTGATCAAAAATAGCAACGTGCTATCATCCGCT
GTCATGTCGTCGTATGTTTCGGGTTCCTGAGATATGCCGAAAAGATGTATATTGTCTATCATCGTATCAA
AAGCCGCGATATGGTTAGCGTGCAGGGTTTGTGTACTGAAAATAGCATATGTCGGTCTGTAGAACGGGGC
CTTGGCAGATTCGTAAAGAACGAAACATGAGAAATTAAGGGAAGGATGTGAAGGTTAATCGATTTATCAA
CGGTGGTTACGCACGTTTGTCATCCCCCCGCCTTCACGATTTGGTGGTTGATGGTGTATTGACGGTGTCT
AAGGGTCATCCATCGGCTTATACATGACTTGCCGAAGTTAGAGCACTGATAATTAGATAGTATTAGAAAC
CCGTGAACATTGTAAATGGTTGTACGTGGCGGATGTTA
Protein Sequence 
>gi|799322149|ref|XP_012048240.1| acid phosphatase [Cryptococcus neoformans var. grubii H99]
MRSAALFALLPILANAAAVERRTADSNVGSTTSDVFPPAGTSVNSKLFPAESVVGYPGATVTGAEPAAAV
TAAAYAYNDGTSNSFPLVADQPTGNGSEGFDVFKYWGNLSPWYSVPSSFYGLNDTSPLIPDSCSITQVHL
LYRHGARYPTSGAGPSTFAAKLADATAQDGGFTAKGDLDFLNKWTYKLGAELLTPFGRLQNFELGVTFRQ
QYGELLNNFTEQGALPVFRTESQDRMVKTAENFAAGFFGVPEYLDQVSIELMVETSGVNNTGAPYETCPN
SNIASRGSLGSTAASSFATDAFNGTVSRLQSYINGVEFDTTDVLAMLQLCSYETDALGYSAFCGVFTEED
FKNYEYYFDLNFYYNNGAGSPVAAAQGKGFLEEFVARFTQTPITSSNSSVNTNLDSNSTYFPLNQSIYAD
ATHEVVLLDTFTAFNLSALFSTGPLPVDKRAEGSSFVASQVVPFATHMVVQVLECADQTPSKQMRFMIND
AVLPLDKSYEGCGWNKDGMCAFDTVVAALQKRIAEIDYDYDCHGDYTVEAGHDYNGRAPRA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The Ãˇâ€¯aph1 mutant had reduced virulece in both Galleria mellonella and mice model (Lev et al., 2014).
References
Lev et al., 2014: Lev S, Crossett B, Cha SY, Desmarini D, Li C, Chayakulkeeree M, Wilson CF, Williamson PR, Sorrell TC, Djordjevic JT. Identification of Aph1, a phosphate-regulated, secreted, and vacuolar acid phosphatase in Cryptococcus neoformans. mBio. 2014; 5(5); e01649-01614. [PubMed: 25227465].