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ALL1(Cryptococcus neoformans var. neoformans serotype D)

Victor ID 5264
Gene Name ALL1(Cryptococcus neoformans var. neoformans serotype D)
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Gene ID 3258361
NCBI Protein GI 58268496
Locus Tag CNF04420
Genbank Accession AE017346
Protein Accession XP_571404
Taxonomy ID 214684
Chromosome No 6
Gene Starting Position 1283096
Gene Ending Position 1284192
Gene Strand (Orientation) +
Protein pI 6.42
Protein Weight 23466.87
Protein Length 234
DNA Sequence 
>gi|58272423:1283096-1284192 Cryptococcus neoformans var. neoformans JEC21 chromosome 6, complete sequence
ACGACAATCAAGACACTTTCCACTCCAATCCATCAACCCAAACCAACGAACACAACAAGCAACAATGTCC
GGCGTTACCCAAGGTGTCAAGGAATTCTTTTCTAAGTCTAGCAAGCCCGAAACCACTGAAGTGCGTCTTT
GTCATTTTCTTTTAGTCGATGTATCCTTAACTTTCGACAATAGGTCTGCACAGACACCGCCCCTGAGGTC
GTTCAGGAGCATATCAGGCCTCAAGAACATGTTGAGACCGCTGAAGCCGTCGACCGCGAGCGACATGTTC
ACCACCTCCAAGTATGTCTTCCTTACTCCCATGTCAACGATCATGACATATGATTTACATATCAACTTTA
GCACCGACTCCAACCCGTTGAGGACAAGCAGACCCTCAACGCCAAGCATATCAACACCACCGAGCCTGTG
ATCACCCGAGAACACAAGGAGGAAATGCGTCCTGAACACCAGGAGGCTCTTGCCAAGCAGAGGAACTTGG
CTCGCGACACCCGATCTACTGGTGAGGTCGAGAAGAGCGGAGCGCATGTGGGTACTGCTGTCAATGAGCA
CCAACACCACCACATCCACGAGACCGGTAAGTTACTTGACGTTCTAACTGTTTTGCAACCCCATTTTTAC
ATATCGCTTGCAGTCCAACCTGTTGTTCAACGCGAGACTGTTGATCCCACCGTTGTCCACAAGACCGAGG
CCATCCATGAGAAGGTTGAGGACGCACCTATTGTCCACGAAGTCACTACCCTCCCCACCATCTCAGCTGA
CAAGTACGCTAAGAACAAGTCTTCCATCGAGGGCGAGGGTGACCACTGCAGTACTTGTAAGTTGTATATT
CTTAGATTAAAACTGCGGAACGCTCTGACAGCTCCCAATAGTCGAGGGTGCCCCTCAGGTTGCTGGCCAG
TCTTCCGGCGTATCTGCTAAGAACACCGCCGCCGACGCCACTTCCACGGGTCGCCATCAGTCCAGCAAGA
CCCAGGCTCTTTAAAAGAATGTGTAGTAGTTTATGGTATCTGAAGGTTAAAGCTTCCATCTCTTATATTG
TAGCAAATAGTAAAATACAATGATAAATGCAAATACTTCGCAATTAG
Protein Sequence 
>gi|58268496|ref|XP_571404.1| allergen [Cryptococcus neoformans var. neoformans JEC21]
MSGVTQGVKEFFSKSSKPETTEVCTDTAPEVVQEHIRPQEHVETAEAVDRERHVHHLQHRLQPVEDKQTL
NAKHINTTEPVITREHKEEMRPEHQEALAKQRNLARDTRSTGEVEKSGAHVGTAVNEHQHHHIHETVQPV
VQRETVDPTVVHKTEAIHEKVEDAPIVHEVTTLPTISADKYAKNKSSIEGEGDHCSTFEGAPQVAGQSSG
VSAKNTAADATSTGRHQSSKTQAL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The Ãˇâ€¯all1 mutants of two serotypes produced a shorter exo-PS with less branching and structural complexity than the parental strains;Ãˇâ€¯all1 mutant strains manifested differences in epitope expression and significant resistance to phagocytosis (Jain et al., 2009; Jain et al., 2013).
References
Jain et al., 2009: Jain N, Li L, Hsueh YP, Guerrero A, Heitman J, Goldman DL, Fries BC. Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans. Infection and immunity. 2009; 77(1); 128-140. [PubMed: 18955480].
Jain et al., 2013: Jain N, Cordero RJ, Casadevall A, Fries BC. Allergen1 regulates polysaccharide structure in Cryptococcus neoformans. Molecular microbiology. 2013; 88(4); 713-727. [PubMed: 23565821].