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ADA2

Victor ID 5259
Gene Name ADA2
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23885322
NCBI Protein GI 799341916
Locus Tag CNAG_01626
Genbank Accession CP003830
Protein Accession XP_012052395
Taxonomy ID 235443
Chromosome No 11
Gene Starting Position 455337
Gene Ending Position 458491
Gene Strand (Orientation) -
Protein pI 5.03
Protein Weight 66873.72
Protein Length 619
DNA Sequence 
>gi|799350881:455337-458491 Cryptococcus neoformans var. grubii H99 chromosome 11, complete sequence
GCGAAAATTGGCACAATTTAGCATCTATGCATACTTTTTACAACCCAAGAACCAAAGCGCTATCTGCTTG
TTTTGATACTTCTGACGAGCTTCGATGAATATATCGTTTTGTACTCCCCTTCTTCTCCTTACGCATATGT
AAGTAAACTTTTTGAAGAATAGTGACTATAAATTTGCTCATCCATTGAGCCTAATCTCATGCGTTATGGG
CTTATTCAACCCATTCGTCATCCCCAGCCCATTCACCCTTTCCATTAACATGTCCTTCCCTTGTGATTGT
CCGTCCATAGTTGTCATACCGTTCGCGGCTCCATGCGCTACGGCGGCAGCGGCTGCTTGCAAACTAGCCT
TCCCTTTGCCCTGCGGCTCATAAGCCAACACCAGCATCCCGCTTTGGACCAGAAAGTCGAATATCCTCCC
ACTCTTGTTGACGTCGATATTCAACATCTTTCTCGCGTCTCGCCGCCTCAGCAGACCTTGACGGCGCTCA
TTCTCACGTATATACAGCTCTTTGATAGTGAGATAAGGTTTGGGCAAAACGCGGAGGGTAGAACAAAGTG
ATTGTTCTTCGGATGAAAGGAGATCGAGAGAGGCCGAATTGGCAAGGTTGAGTGGTTGAGCTGTTGGGAA
TGTCAGCCATTGGTTCAGGCAGTATATCGACATCACACCCACGAGGTTTGCGTCCAACTGCAGGGACGGC
TCTGGGCGTAGGCTCTCGAGTTTTCGCATCTGGAAGAGGCGTAGACATGGTACCGTGTAAGAACCTGTGT
TGACCGGCGTTGATTCTCGCACCAGACGGTAAGACTTCTGCTGGCTTTTGTGTGGGGAATTCCATGGCCT
GTTGATGGAATCCTTAGTAAGTAAGCGATACTTTAGAAAAGCTGAAAACCTTACGCGTGTATTCTTCACA
TTATCATAGACATCCGCTTCAGCTGCTGTCGTTATTCCCATGCGACGGTATTCCTGGAGTTCCGCTATCC
GCTTTCGAAGAGTTTGTTCGTCTTTTCTCTCGGGTTAGCGACATACTTTTATTCCAAATCACGAGGAAAC
GTACAGATCAAACCTTCCACAAGAACTTCAAAGTCTTCGGCAGTTTGCAACTTTGCAAATGGTTTATAAC
GTTGTACCAACTCTCTCTCCTCCTTGGTAAGTTTCTTTTCTTGCGCTTGTATCTTTAAGTCGTCATCAGT
ACTATCCTTCCATCAGGGGAGAGAACATGTACTCACAGCCCGATACTCTGTTAATCCCCTATCAAATATG
ATCTCCTTGGCATCCTCTCTCTTGTCCAACTTTGAGAAATAAATGTCCATCATTGCAAGCTTCACTTCCA
GTTCGTCGGGATCTTCGACCGCAGGGGATACCGGTTTGTCTTCCTTTTCATCTTCCTTTTGCTTTTCCTT
TTTCACTTTTCCCTTTTTTTCCACGCCCTTTTCATCTTCTCCCTCTTCGTCTTCGTCTCCTTCCTCTTCT
TCATCTGGAGGACGAGTGATCTTTGCCTGTGGTTGTTCGTCACCGCCATATTGCATTACGAGTCCAAACT
CCATATCCTTTACAGCCATTTCGGCATCATTGTCTACTTCGTGCTCGAATTCGAGACGAGCCGGCATGTA
ACCGCCGATTTCGTGATTTGTGGGTGCCGAGACTGGTGGGGCAGCGTTGGACGGCGGTAAAGCTGAAGCC
AATGTTAGTGAGAGTAAGGAAGAGGTGTGAAATGGCCATACCTTGCGGTTTACGAAGTTCCTCTATCCGA
GCTTTTTTGCGTTGCTGGAATTCATCTGGATCATAAGGGAAGCTCCTGTCCATAGGCTGAAAATTCCGTC
AACAAAGGACTTGTCAACAATCTCATGAACATACAGGCATGAATTCCCTTCTACGTCTCTTGGACTCATC
CATCTCCTCATCTTGTTCCCTCTCTTTCACCCTCAGGTCCTCTCCGTGTTCGCCCACACCAAGGTAAACT
TGAAGGTAATGTTGTTCGCATTCTTCTTTAGTTCTTGTCCCGACATGTTGCGCCACTTCAGCCCAGTTGC
CCAGACCGTTTTGAATGAGGCCAGATATTAACAGTAGCTCTTCGTCGGCTCCCCAATCTGGGGTGAATAT
CGGTTGAGAGTTTTGTTCCTGTTTCCTATTAGATTGACCCTTGCGCAGTGAAGATAAGGACATACAACAA
CCATATAGTCATGCCATGCCTTATGTTGCAAGCCTTCTTTACCCTCGCAAAAGCAAGTTGGACAGAGATC
GACCTCCTCGCATTGCTTCATAGCGCATTTTATACGTACGGTATGGGTGATATCCACATGGCCTGCTTGT
TCGTCAGCAGCTGACGCGCAAAGATGAAGCTGTATGATGTGACGTACAGAAATCACACGTATACTTGATA
CCTGGCTCAATAACTACACAGTATCAGCAAAAGTCGTCAAAAGGACGAACAGAAAAGAAACGATAGACGT
ACTGGGTCGGCTATCGTTTTGGGCATTATCCACCCTCGGCTTCCTCTGCGTGACAGTCATACTCGTTTGT
TGATGCCTTTAACGTGCCTCTTATTGCACGTCAAAGCAGTCTTGCTGGAGCACGCCTCCGAGTGCCCGCT
TCAGGTTGTCAACAAAAGGGATGATCACGGGGAGACGCGAATATGGGCTGGCGGGTCTCGCCGCGGTGGA
GGCGCGTGATTCGATCGTGTTTGGTTGCGTGGTCGCGTGGCGGGGGGGATGGGGGATAGAGGGAGGCGAG
CGGAAGGGGGATGTGGGTATAACGCGGTGGAGGCAGTGAGAAGGGCAGGATCGAGGTGTATGCACGGTGA
GGGATGATATAATAGAACGTCAGGGTCAAAGGATTGAGGTAATGTTGTTGGGCGCGCGGTCGAGGGCCAC
AAACAGCGGCGGGTTCCGTGTGCTTCCGGCGGGCGCCGCAGCTGCTTGGTGCGGTGTGGTGGGGTGCAAG
TGGGGAGAAGGCGGGCGGGGGGATGGCGGCGCAGTGGTGAGGGGCGACGGCGCGGGGGGGAAGAGAGAGG
GCAGGAGGGGGAGGGGTACGGTGGCGGGTGGTGCTGCTTGACAGTGTGTTGTCGGAGGGGGGGCGCCGAC
TCGCTGGCTGGTGGTGATGGCGCAACTCGGAATCCCGGCAGATGACCTGGAATCCAGGGAATCCCACCAA
TCACG
Protein Sequence 
>gi|799341916|ref|XP_012052395.1| transcriptional adapter 2-alpha [Cryptococcus neoformans var. grubii H99]
MTVTQRKPRVDNAQNDSRPIIEPGIKYTCDFCHVDITHTVRIKCAMKQCEEVDLCPTCFCEGKEGLQHKA
WHDYMVVEQNSQPIFTPDWGADEELLLISGLIQNGLGNWAEVAQHVGTRTKEECEQHYLQVYLGVGEHGE
DLRVKEREQDEEMDESKRRRREFMPPMDRSFPYDPDEFQQRKKARIEELRKPQALPPSNAAPPVSAPTNH
EIGGYMPARLEFEHEVDNDAEMAVKDMEFGLVMQYGGDEQPQAKITRPPDEEEEGDEDEEGEDEKGVEKK
GKVKKEKQKEDEKEDKPVSPAVEDPDELEVKLAMMDIYFSKLDKREDAKEIIFDRGLTEYRAIQAQEKKL
TKEERELVQRYKPFAKLQTAEDFEVLVEGLIYEQTLRKRIAELQEYRRMGITTAAEADVYDNVKNTRAME
FPTQKPAEVLPSGARINAGQHRFLHGTMSTPLPDAKTREPTPRAVPAVGRKPPQPLNLANSASLDLLSSE
EQSLCSTLRVLPKPYLTIKELYIRENERRQGLLRRRDARKMLNIDVNKSGRIFDFLVQSGMLVLAYEPQG
KGKASLQAAAAAVAHGAANGMTTMDGQSQGKDMLMERVNGLGMTNGLNKPITHEIRLNG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: This factor is a homolog of the yeast protein Ada2, a member of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex that regulates transcription of stress response genes via histone acetylation. The mutant exhibits significant defects in in response to a variety of stress conditions, sexual development and virulence (Haynes et al., 2011).
References
Haynes et al., 2011: Haynes BC, Skowyra ML, Spencer SJ, Gish SR, Williams M, Held EP, Brent MR, Doering TL. Toward an integrated model of capsule regulation in Cryptococcus neoformans. PLoS pathogens. 2011; 7(12); e1002411. [PubMed: 22174677].