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ACL1

Victor ID 5257
Gene Name ACL1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888032
NCBI Protein GI 799340552
Locus Tag CNAG_04640
Genbank Accession CP003829
Protein Accession XP_012052118
Taxonomy ID 235443
Chromosome No 10
Gene Starting Position 797557
Gene Ending Position 801912
Gene Strand (Orientation) +
Protein pI 7.17
Protein Weight 116554.6
Protein Length 1149
DNA Sequence 
>gi|799350850:797557-801912 Cryptococcus neoformans var. grubii H99 chromosome 10, complete sequence
CGCTGCATCCATTATGTTCAATTCCTATCTCCATTTCTCTTCTTCTTTTCTTCTTTCTTTGGCTTTTATA
GTCATAATTACATTGCTACTACCCTCCCCCTTTCTCTCTCTTCCTCTCTCTTATACCCGTAAGTTGTCCG
ATCGCTCGTACGCCGCGGCCTCCTGTCGCTTCCACCGCGCTCGCTGTTTCCACCTTCCACGTACCCATAG
CTTACAACTTCACGCAGCTCTAGGTCAGAGCCTATACTAGACACTCCATCATGTCCACCAAGGGTGAGTT
GGCGTTTCTTCATCACGCACATGTTTTCGACATGCAAACCATTCCCTGTTATCTTGGCCGGCCGAAAATA
GATTTCGCGTCGTTTTATGTTTTCGAAAAAGGCTGACCACGAATAATATCGCATCGTAGCTATCCGCGAG
TACGACGCCAAACAGCTCGTCTCTTACTGGCTTAACCGCTCTCCTACTCCTATTCCCTGTAAGACCGACA
CTTCTTTTACCGCTGTCAAGGTTGCTCAGGTGCAATGGTGAGTTATTCTAGAAATGGCTGTGGACATCAG
CTGACTTAGTTTTTTTTCAAGGGATCCTGCCACCAAGCAGCTCTCTCCTCCCATTAGGCCCGGACAAGGT
CTCCCCGATTGGGTCTTCTCCTCCAAGCTCGTCGGCAAGCCCGATCAGCTTATCAAGCGACGAGGAAAGG
CTGGTCTCCTGTGCCTCAACAAGGGCTGGGAAGAGACTGGCGCTTGGATCGAGGAGAGGGCCGGCAAGCC
CGTGACCGTTGAGAAGACCACCGGTACTCTCAACACCTTCATCATTGAGCCCTTCTGCCCTCATCCTGCT
GAGACTGAGTACTACGTCTGCATCAACTCTGCTAGGGAGGGTGACTGGATCCTCTTCACTCAGTGAGTTC
GCCTTTGGTTGGACATCTGAATTGTGCTGACTCTACGCAGCGAGGGTGGTGTGGACGTTGGAGATGTTGA
CGCCAAGGCGCTCAAGTTGCTCATCGCTGTTGGGGAGGAGTTCCCTACTCGTGAGACCATCATTAGCACC
CTTCTCGCCAACGTCGCCCCTGCCAAGCAGGATGTTCTCTGTGACTTCTTGATCAGGCTTTACGGTGTTT
ACGTTGACTTGCACTGTAAGTGCACAACTTCGAACACACTCTAGGACACAGCTAACAATTATTTCCAAGT
CGCCTACCTTGAGATCAACCCTCTTGTCTGTCTCGATGCTGTTGATGGCAAGCCTGCCGAGATCCAATAT
CTCGACATGGCTGCCAAGCTTGATCAGACTGCTGACTTCCTCTGTGGTCCTATGTGGGCTGTGGCTCGTG
ACGTCTCTTCCACTACTAGCGGTGCCACTGGAATCAAGGCTGACCGCGGACCTCCCATGGTCTGGCCCGC
TCCGTTCGGTCGTGACTTGACCAAGGAAGAGGCTTACATCCAGAAACTCGACGCCTCTACCGGTGCTTCC
CTCAAGCTCACTGTTCTTAATTCTGAGGGCCGAGTCTGGACCATGGTTGCCGGTGGTGGTGCCTCTGTTG
TCTACTCCGACGCCATTGCCGCGGCTGGTTTCGCCCATGAGCTTGCCAACTACGGTGAATACTCTGGCGC
CCCCACCGAGGGTCAGACCTACGAGTACGCTAAGACCATCATCGACCTTATGACCCGAGGCACCCCTCAC
CCTGAAGGTAAGGTCCTCATCATTGGCGGTGGTGCTGCCAACTTCTCCGACGTTGCTGCCACATTCAAGG
GTATCATCCGAGCCCTCAAGGAGTACAAGGAGGGTCTCCTTCGACACAATGTCAAGATCTGGGTGCGACG
TGCTGGTCCTAACTACCAGGAGGGACTCAAGGCTATGCGTCTCTGCGGTGAATCTCTGGGTGTCTTCATG
AAGGTCTACGGCCCCGAGTCTCCTATCACTGCCATCGTCCCCATGGCTCTTGGTATCGAGCGACCTCCTA
CCGCCATCACCCGTGATGTTACTCCTATCCCTTCTGCCCCCGTCACTCCTCCTAACGGTGCTGCCTCTGG
CATTGCCAACATGGCCAACAATGTCGGTGCTGTCAAGGCTGATGGCAGCCGAGAGCAGCCCAACGACCAG
ATTGTCAGGTTCGACACTGAGCCCATCACTGGCTCTCGACCTTGGTTCCGACCCTTCGACGAGCACACCA
GGTCTTTCGTCTTTGGTCTCCAGCCCCGTGCCATTCAGGGTATGCTCGACTTTGATTTCTCTTGTGGTCG
AAAGGTTCCTTCTGTCGCTGCTATGATTTACCCCTTCGGTGGTCACCACATTCAGAAGTTCTACTGGGGT
ACCAAGGAAACTCTCCTTCCCGTCTACACTTCCGTCGGTGAGGCTATCAAGAAGCACCCTGACGTTGACG
TCGTTGTCAACTTCGCTTCTTCGCGATCCGTCTACGCTTCTACCCTCGAGATCCTCTCTTTCCCTCAGAT
CAAGGCCATCGGTATCATTGCTGAGGGTGTTCCTGAGAGGCACGCTCGTGAGCTCCTCCACCTCGCTCTC
AAGAAGCAGGTCATCATCATCGGCCCTGCTACCGTCGGTGGTATCAAGCCTGGATGCTTCAGGATTGGTA
ACACTGGTGGTATGATGGACAACCTTATTGCGTGCAAGCTTTACCGACCTGGTTCCGTCGGCTACGTCTC
CAAGTCTGGTGGTATGTCCAACGAGCTCAACAACATCCTCTCATACACCACCAACGGTGTCTACGAGGGT
GTTGCCATCGGTGGTGACCGGTACCCCGGTACTTCCTTCATCGACCACCTTCTCCGATACGAGGCCGACC
CCGAGTGCAGAATGCTCCTTCTCTTGGGTGAGGTCGGTGGTACTGAAGAGTACCGAGTTATCGAGGCCGT
CAAGCAGGGTATCATCAAGAAGCCCATCGTTGCCTGGGCCATCGGTACTTGTGCCAAGATGTTCACCTCT
GAGGTTCAGTTCGGTCACGCCGGTTCCATGGCTAACTCCGACATGGAGACTGCCGACGCCAAGAACAGGG
CCATGAGGGCTGCTGGCTTCATCGTTCCTGACACCTTTGAGGACCTCCCCGACACTCTCAAGGCTGTCTA
CAACCAGCTCGTCACCAAGGGCGCCATCGTTCCCAAGGCCGAGATCGAGCCTCCTCAGATTCCTATGGAC
TATCAGTGGGCCTCTGTAAGTTACTTATCTTATAAATCTTCTGTTTCTCGACTAACCTCTCATCTAGAAA
CTTGGTCTCATCAGGAAGCCCGCCGCTTTCATCTCTACCATCTCCGACGAGCGAGGCCAGGAGCTCATGT
ACGCTGGTATGCGAATCTCCGACGTCTTCAAGGAGGAGATTGGTATCGGTGGTGTTATCTCTCTTCTTTG
GTTTAAGCGACGACTTCCCGCCTACGCTTGCAAATTCATCGAGATGGTTCTTCAACTTACCGCCGACCAC
GGTCCCGCCGTTTCCGGTGCTATGAACACCATCATCACTGCTCGTGCCGGCAAGGACCTTATCTCCTCTC
TTGTTGCTGGTCTCTTGACCATTGGTGACAGATTCGGCGGTGCTCTTGATGGTGCCGCTGCCGAGTTCTC
TAACGGTCTTACCTCTGGTCAGACTCCTCGAGAGTTCGTTGATTCTATGCGAAAGGCCAACAGGCTCATT
CCCGGTATCGGCCACAAGATCAAGAGCAAGACCAACCCTGATTTGCGTGTTGTCCTCGTTGTTGACTTCG
TCAGGAAGCACTTCCCCAACCACAAGACCCTCGACTTCGCCCTTGCTGTTGAGGACGTCACCACCCAGAA
GTCTGGTTCTCTTATCTTGAACGTTGACGGTGCCATCGCCGCTTCCTTCTGTGATTTGGTCAGCGGATGC
GGTGCCTTCACCGAGGAAGAGGCTCAGGAGTACCTCAAGAACGGTACTCTCAACGGTCTCTTCGTTTTGG
GTAGGAGTATCGGTTTCATTGGTCATTACCTTGACCAGAGGTTGCTCAAGCAGCCCCTTTACAGGCGTAA
GTCACTATCCTTCTTAATATCTATTGCAGTCACTGACTAGACTTCTACTTACAGACCCTCACGACGACAT
CTTCTACCCCTCTGCTGAGCGTGTTGTTATTCAACCCGGCAAGAAGGCTTAAACGTAGGCGTCAACACAA
CGAAAATTGTTAAAAATAGATTTTGTATTTAGGGACTCATGTGTGATATTCCATTTTCCTTCCTTCCATT
TCATTCCAATTCACATCTATTCTTCCACCCTCAAAATGCCCCCAAAATGCCTGTAGAGGCATAGTCATTG
ATATTAGATGAGTACATACCGAGGTGCGATGCACGCTGGCGGTTCATGATTTATCCTAAACACTGTTCAC
CAACTATTCAACCGGA
Protein Sequence 
>gi|799340552|ref|XP_012052118.1| ATP-citrate synthase subunit 1 [Cryptococcus neoformans var. grubii H99]
MSTKAIREYDAKQLVSYWLNRSPTPIPCKTDTSFTAVKVAQVQWDPATKQLSPPIRPGQGLPDWVFSSKL
VGKPDQLIKRRGKAGLLCLNKGWEETGAWIEERAGKPVTVEKTTGTLNTFIIEPFCPHPAETEYYVCINS
AREGDWILFTHEGGVDVGDVDAKALKLLIAVGEEFPTRETIISTLLANVAPAKQDVLCDFLIRLYGVYVD
LHFAYLEINPLVCLDAVDGKPAEIQYLDMAAKLDQTADFLCGPMWAVARDVSSTTSGATGIKADRGPPMV
WPAPFGRDLTKEEAYIQKLDASTGASLKLTVLNSEGRVWTMVAGGGASVVYSDAIAAAGFAHELANYGEY
SGAPTEGQTYEYAKTIIDLMTRGTPHPEGKVLIIGGGAANFSDVAATFKGIIRALKEYKEGLLRHNVKIW
VRRAGPNYQEGLKAMRLCGESLGVFMKVYGPESPITAIVPMALGIERPPTAITRDVTPIPSAPVTPPNGA
ASGIANMANNVGAVKADGSREQPNDQIVRFDTEPITGSRPWFRPFDEHTRSFVFGLQPRAIQGMLDFDFS
CGRKVPSVAAMIYPFGGHHIQKFYWGTKETLLPVYTSVGEAIKKHPDVDVVVNFASSRSVYASTLEILSF
PQIKAIGIIAEGVPERHARELLHLALKKQVIIIGPATVGGIKPGCFRIGNTGGMMDNLIACKLYRPGSVG
YVSKSGGMSNELNNILSYTTNGVYEGVAIGGDRYPGTSFIDHLLRYEADPECRMLLLLGEVGGTEEYRVI
EAVKQGIIKKPIVAWAIGTCAKMFTSEVQFGHAGSMANSDMETADAKNRAMRAAGFIVPDTFEDLPDTLK
AVYNQLVTKGAIVPKAEIEPPQIPMDYQWASKLGLIRKPAAFISTISDERGQELMYAGMRISDVFKEEIG
IGGVISLLWFKRRLPAYACKFIEMVLQLTADHGPAVSGAMNTIITARAGKDLISSLVAGLLTIGDRFGGA
LDGAAAEFSNGLTSGQTPREFVDSMRKANRLIPGIGHKIKSKTNPDLRVVLVVDFVRKHFPNHKTLDFAL
AVEDVTTQKSGSLILNVDGAIAASFCDLVSGCGAFTEEEAQEYLKNGTLNGLFVLGRSIGFIGHYLDQRL
LKQPLYRHPHDDIFYPSAERVVIQPGKKA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ACL1 Gene is responsible for ATP-citrate lyase synthesis and acl1 mutants were unable to cause disease in a murine inhalation model (Griffiths et al., 2012).
References
Griffiths et al., 2012: Griffiths EJ, Hu G, Fries B, Caza M, Wang J, Gsponer J, Gates-Hollingsworth MA, Kozel TR, De Repentigny L, Kronstad JW. A defect in ATP-citrate lyase links acetyl-CoA production, virulence factor elaboration and virulence in Cryptococcus neoformans. Molecular microbiology. 2012; 86(6); 1404-1423. [PubMed: 23078142 ].