Victors

pgaA
Victor ID	5235
Gene Name	pgaA
NCBI Nucleotide GI	259020297
NCBI Protein GI	259020298
Locus Tag	ACV90433
Protein Accession	ACV90433.1
Other Database IDs	CDD:223533 CDD:276809 CDD:224544
Taxonomy ID	470
Gene Strand (Orientation)	?
Protein Name	PgaA
Protein Length	747
Protein Note	Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457
DNA Sequence	>gi\|259020297\|gb\|FJ866497.1\| Acinetobacter baumannii strain S1 PgaA (pgaA) gene, complete cds ATGTCAAGTGAAAAAAGGGATCTTACGAATTTTTCACGGTTTTTGGTAAATATTAATTATGTAGACTTTC TAGAATATGCAAAGTTACCTTTAATTCAAAATTTTCGTGATTTTAAGCATTTTAAAACTGCAATTGACTG GTCAAATAAGTTCAATATTCAAAAGTCAGTTGATGGCCGTATTTTATTATCGGTTTTGTATGCTGAAGCT CAAGATGTGGCGAATGCTAAAGATCAGTTGTCGAAGATCGATATTAAAGGTTTAACTGCTGATCAGTTGG TACGGGTTGCATATGCTTATCGTTTAATAAATTTACCCGTAGATGCTTTAGCTACAGTTGAGCATGCTTA TCAACAACAACCAAAATCTTCATCCGTTTTACAAGAATATGTTTACGATTTAATTGCTATTGGCTCATAT AAAAAGGCACAGCAATTGCTGCAAGCGAGCGAAAAAACTGAACAAGCAGTGCAAATGTTGCAGACTTTAC AAGTTAGTGAGTTTTCTCAACATATCAACAATGCAATTGCTCGATATAAATATTTAAATCGCGAAGGACT AGCCGATGCCGAAAGCTTTGCTGAATTAGATAAAGTGCTGGAGCAAGGACAAAAAATGCATCAGCAAATG AATCCTTCCGATCCTAATTACTTACGGTTTTATTACGATTATTTATATGGATTAGATTTTAGAGGGCGTT CAAAAGCGGCTATAGAGAGTTTCACCCAGTTGAATATTCCACTCGAAAAATTACCGGCATATGTACGTCA TGCAATTGCTGATAGTTATTTGGCGGAGCAAAAACCGAAACAGGCCGAGTTTGCTTATAAAACGCTTTTA ACCGAAAAGAATTATCCGGATATGACCGTATATACGGGACTGTATTATTCTTATATTGAACAAGAAAAAT ATAAGGAAGCTGAACAACTTCTCGCTGAAGTTGATCGGCTTATTCCAACTTATAAATATAGTCAGGCTAA GGGTGTAGATAAAATCAGTCATCCTGATCGTGATGATTATATTGCTTTACAAGGAATGCATTTAGCCTAC GCTAATCATCTGGATCAAGCTGAAAAGCATTTTCAAAAAAAAGTAGAGCAGGCGCCTGCGAATGAGAGCT TGATTAATAATCTTGCGCGTGTAGAACGGTGGAGAGAAAAACCGCTAGAGGCAAAAAAAACAATTTCCCG GTTAAATGGTATAGATCCGATTGCTAAAGACACCCGCATTAATGAAATGCAAAATGCTCAAGCTTTAGGT GATATTCCGACATGGCGAAAAACGACTCAAAACTTATTGCAATATTACCCTGATGATAGTGGGGTCATTA AAAGTCGAAAAGAATTAGAAGATCGTAATAGAGCCACAATTTCACACTCAACCACTTGGGGCCAAAGTAA GGCCGACGGTCGCGATACTGTAAGTGGGCAGAATGGTTTAAAAGACCGTGAAATGGAAACGCGTCTTAAT AGCCCTTGGATTAATGATAATTATCGTTTATTCGCTTGGCATCAAGATCGTTATGGGGAGTACCGTTTTG GTGATGTGCATGACCAGCGTTATGGGGTCGGAGCAGAATGGCAGGCGAACCGTAAGGCGTTGTCGGCAAT TGTGTCGCAAAGTACGGATGGTGGACAAGCAGGAGTCCGTCTTGATTGGTCCCAATGGCTAAACGACCAC TGGCAGTATCAATTGCAATATAACAGTCAGGCTGACATTCCTTTACAAGCCCTTGATGCAGGGGAAGATG GTCAATCTTACCGAGCTGCTGTCACATGGCAAAAAGATGAATCTCGCCAGATTGGCGCGAGTTACGGTTT AACTGATATTAGTGATGGTAACAAACAACAAGAATTTTCAACATTTTGGCGTGAAAGACTATTCGACGCA CCTCATCATATTACGTATGGCACTGTTCGAGGTTTCTACGGTACTAACAGCCAAGATCAAACAGCTTATT TTAGTCCAAGTTCACATTACAGCGCTGAGTTGAACTTAAGTCATGACTGGGTGACTTGGCGTGAATATGA GCGTTCATTTAAGCAGCATTTTGAAGCGGGTGTAGGCCTTTATAAACAGGCCGATTACTCTGTTAAACCC ACTTACTCTTTGCAATATCAACATCAATGGCAGCTATCCCGGACATGGCAGCTCAATTATGGAATTGGTT GGCAATACCATCCTTACGATGGACATGATGAACAACATACCTACGGTATTTTTGGATTTGAAGGGCGTTT TTAA
Protein Sequence	>gi\|259020298\|gb\|ACV90433.1\| PgaA [Acinetobacter baumannii] MSSEKRDLTNFSRFLVNINYVDFLEYAKLPLIQNFRDFKHFKTAIDWSNKFNIQKSVDGRILLSVLYAEA QDVANAKDQLSKIDIKGLTADQLVRVAYAYRLINLPVDALATVEHAYQQQPKSSSVLQEYVYDLIAIGSY KKAQQLLQASEKTEQAVQMLQTLQVSEFSQHINNAIARYKYLNREGLADAESFAELDKVLEQGQKMHQQM NPSDPNYLRFYYDYLYGLDFRGRSKAAIESFTQLNIPLEKLPAYVRHAIADSYLAEQKPKQAEFAYKTLL TEKNYPDMTVYTGLYYSYIEQEKYKEAEQLLAEVDRLIPTYKYSQAKGVDKISHPDRDDYIALQGMHLAY ANHLDQAEKHFQKKVEQAPANESLINNLARVERWREKPLEAKKTISRLNGIDPIAKDTRINEMQNAQALG DIPTWRKTTQNLLQYYPDDSGVIKSRKELEDRNRATISHSTTWGQSKADGRDTVSGQNGLKDREMETRLN SPWINDNYRLFAWHQDRYGEYRFGDVHDQRYGVGAEWQANRKALSAIVSQSTDGGQAGVRLDWSQWLNDH WQYQLQYNSQADIPLQALDAGEDGQSYRAAVTWQKDESRQIGASYGLTDISDGNKQQEFSTFWRERLFDA PHHITYGTVRGFYGTNSQDQTAYFSPSSHYSAELNLSHDWVTWREYERSFKQHFEAGVGLYKQADYSVKP TYSLQYQHQWQLSRTWQLNYGIGWQYHPYDGHDEQHTYGIFGFEGRF
Molecule Role	Virulence factor
Molecule Role Annotation	Deletion of the pga locus (the pgaABC genes) led to loss of the strong biofilm phenotype, which was restored by complementation (Choi et al., 2009). A. baumannii pgaA encodes a predicted 812-amino-acid outer membrane protein that shares 26% identity with E. coli PgaA, 23% identity with Y. pestis HmsH, and 25% identity with B. pertussis BpsA. In E. coli, PgaA contains a predicted porin domain that facilitates PNAG translocation across the outer membrane, as well as a superhelical periplasmic domain that is thought to play a role in protein-protein interactions. In Y. pestis HmsH has been demonstrated to be an outer membrane protein (Choi et al., 2009).
References	*Choi et al., 2009:* Choi AH, Slamti L, Avci FY, Pier GB, Maira-LitrÃ¡n T. The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-beta-1-6-N-acetylglucosamine, which is critical for biofilm formation. Journal of bacteriology. 2009; 191(19); 5953-5963. [PubMed: 19633088].


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