Victors

pgaB
Victor ID	5234
Gene Name	pgaB
NCBI Nucleotide GI	259020299
NCBI Protein GI	259020300
Locus Tag	ACV90434
Protein Accession	ACV90434.1
Other Database IDs	CDD:276114 CDD:274867 CDD:277447
Taxonomy ID	470
Gene Strand (Orientation)	?
Protein Name	PgaB
Protein Length	510
Protein Note	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; cl15692
DNA Sequence	>gi\|259020299\|gb\|FJ866498.1\| Acinetobacter baumannii strain S1 PgaB (pgaB) gene, complete cds TTGTTAACTTTCGATGATGGCGCTTTAAGTAGTTATAGCCGTGTATTTCCATTACTTAAGCAATATCAGA TTCCGGCAGTATTTGCACTTCCGACCAGTTGGCTAAATGGGAATACACAAGCTGGCTATGAAGCGTATGG GCAAGGAAATCTAGTCAATTGGAAGCAAGTGCGAGAAATGCAAGCTTCGGGCTTAGCCGAGTTTGCAAGT CATAGTGATGATTTGCATCATGGAGTATTGGCTAATCCTCAAGGGAATGAACAGCCTGCTGCGACTTCTT ACGCGTATTTAAAATCACAAAAGCGTTATGAAACGGATGCAGAATATCAACAACGTATTTTGCAGGACTT AAAAAAATCATACGCCGTTTTAAAGAAAGAAGTGGGTGTTGAACCTAAGGCAATTATTTGGCCTTATGGC GCTGTGAATGAGCAATTAGAAAAATTGTCTCAAGAAGCAGGCTTTATTTTTTCTTTCAGTTTAGGACGTG ATGGAATGAATAGGGTGAGTGACTCGACTTTTAAACGTAGTTTGGTCACTAATAATCCTACAGCTGAGCA ATTAACAGAGGGTATGATCAATATTCTCAACTTTGAAGAATTAGATTTATTTAAGCAACCTCGCCACTTT GTGAGTATGGACTTAAAACAGTTAGCTGCTTCAACTAATACTCAGTCAGATGAGAAACTAGGGTTATTGT TATCCAAGCTTTATAGCTTAAAAAATAACACATTGATATTGAAACCTTTAGATGATCAAGATGGCGATGG GCAGTATGACATTGCTTATTTCCCAACAAATCAACTAAGCGTCCAGCAAGATATTTTGAACCGAACTTTA TGGCAGGCACAAACTCGTGCCGGACAGTCGGTTATTTTAGAGTTGCCTGTATATCCTCAAAAAAATAAAC CGTTTTTGGTGGCAGATTTAGCGAAGGATATCGCACGTTTCAATAGTAATTTAAGTGGTATTCAACTTAA TGCTGGAACCACTTTAAATTGTGCTATGCAAAGCACAACAATAAAAGAAAATGCCTGTGCTGACCAATTA AAACAGCTTACATATGTGAGCCAGCTTACTCAAAAGGCTGTGAAGCCTTATTTAAACATGAGTAATCAGG CTCAGTTTAGTTTATTGCTTACACCTGATTTTGAACATATTGAAAATTTACCAACGCTTTTAAAAACGCT GTTATCCCAACATGATTTAGTAAATCTTAAGTTCAATATAGTGGGTAAGCAAAAACAGTTTAATCACGTA TTAGCAATTTTAAATACGCTTGATGTGAAATATAAACAGCGCATTATGCTGACTTTATCATTACCCGAAA ATAGTCAGCAAAATGCCTGGCAAGAAGTGAAACAAGGTCTTTTCAATATTCAGCGCATAGGTATTCAGAA ATTTGGGGTTGATGGCTATACCAATGAAAACTCAAAAAATGTTCATGAATATTTATATAACCCGATTAGT TTAAATTCGAGTTCGGTCATGTATCAGCCCTTTGCAGGTCTCGCGACTGAGGGGAAAAAGTAA
Protein Sequence	>gi\|259020300\|gb\|ACV90434.1\| PgaB [Acinetobacter baumannii] MLTFDDGALSSYSRVFPLLKQYQIPAVFALPTSWLNGNTQAGYEAYGQGNLVNWKQVREMQASGLAEFAS HSDDLHHGVLANPQGNEQPAATSYAYLKSQKRYETDAEYQQRILQDLKKSYAVLKKEVGVEPKAIIWPYG AVNEQLEKLSQEAGFIFSFSLGRDGMNRVSDSTFKRSLVTNNPTAEQLTEGMINILNFEELDLFKQPRHF VSMDLKQLAASTNTQSDEKLGLLLSKLYSLKNNTLILKPLDDQDGDGQYDIAYFPTNQLSVQQDILNRTL WQAQTRAGQSVILELPVYPQKNKPFLVADLAKDIARFNSNLSGIQLNAGTTLNCAMQSTTIKENACADQL KQLTYVSQLTQKAVKPYLNMSNQAQFSLLLTPDFEHIENLPTLLKTLLSQHDLVNLKFNIVGKQKQFNHV LAILNTLDVKYKQRIMLTLSLPENSQQNAWQEVKQGLFNIQRIGIQKFGVDGYTNENSKNVHEYLYNPIS LNSSSVMYQPFAGLATEGKK
Molecule Role	Virulence factor
Molecule Role Annotation	Deletion of the pga locus (the pgaABC genes) led to loss of the strong biofilm phenotype, which was restored by complementation (Choi et al., 2009). pgaB encodes a predicted 510-amino-acid protein with a putative polysaccharide deacetylase domain. It shares 33%, 31%, and 37% identity with E. coli PgaB, Y. pestis HmsF, and B. pertussis BpsB, respectively. All these proteins have putative deacetylase activities. In Y. pestis, HmsF was isolated from the outer membrane by cellular fractionation. E. coli PgaB is predicted to be an outer membrane lipoprotein that, along with PgaA, is necessary for PNAG export (Choi et al., 2009).
References	*Choi et al., 2009:* Choi AH, Slamti L, Avci FY, Pier GB, Maira-LitrÃ¡n T. The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-beta-1-6-N-acetylglucosamine, which is critical for biofilm formation. Journal of bacteriology. 2009; 191(19); 5953-5963. [PubMed: 19633088].


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