Victors

PDE
Victor ID	5203
Gene Name	PDE
NCBI Protein GI	208657264
Other Database IDs	CDD:224441 CDD:250780
Taxonomy ID	6183
Gene Strand (Orientation)	?
Protein Name	ecto-phosphodiesterase
Protein Length	458
Protein Note	Uncharacterized proteins of the AP superfamily [General function prediction only]
Protein Sequence	>gi\|208657264\|gb\|ACI29972.1\| ecto-phosphodiesterase [Schistosoma mansoni] MYCIETMQKMIILLLICFFPYIERIYASGVVGKEQFSKVILISLDGFRYDYFDMAKQRNINMSAFDKIIN QGVYIRRIENEFPTLTFPSHFSIVTGLHPGSHGIVDNVFYDPIINATFSSRNQSTATDSRFYDVGAEPIW VTNQFHGHKSGVTFWIGSEAIIKGERPTHYLTPYNESITFTQRIDILMDWFEHENINLGLMYYHQPDRAG HIHGAASDEVFKAIEEINHGLEYLLTSIEMRPSLSCCLNLIITSDHGMTNISSDRVIYLHDYIHPNEYIS APKKSAEIWTLWPKQGYTVRSLYNKLKDRHFRLNVYLKEELPTRFFYGSSDRVGPVVVYADIGWTIIADR TSGITLKNKGAHGYDPDYKEMSPFLMAMGPQIAKSQPTELKESIKLIDIYSLICLMLDLEPAPNNGSVCR VLPLLSQGSFANINRLSIIFIIKFIILSIFMVHNGLYY
Molecule Role	Virulence factor
Molecule Role Annotation	The effects of suppressing expression of the SmNPP-5 gene in vivo were tested by injecting parasites into mice. It was found that, unlike controls, parasites whose SmNPP-5 gene was demonstrably suppressed at the time of host infection were greatly impaired in their ability to establish infection. These results demonstrate that SmNPP-5 is a virulence factor for schistosomes.(Bhardwaj et al., 2011)
References	*Bhardwaj et al., 2011:* Bhardwaj R, Krautz-Peterson G, Dadara A, Tzipori S, Skelly PJ. Tegumental phosphodiesterase SmNPP-5 is a virulence factor for schistosomes. Infection and immunity. 2011; 79(10); 4276-4284. [PubMed: 21825060].


Search: for Help

PDE