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VGS

Victor ID 5201
Gene Name VGS
Sequence Strain (Species/Organism) Trypanosoma brucei brucei strain 927/4 GUTat10.1
NCBI Gene ID 3655979
NCBI Protein GI 72386443
Locus Tag Tb927.3.340
Genbank Accession CP000066
Protein Accession XP_843646
Taxonomy ID 999953
Chromosome No 3
Gene Starting Position 65864
Gene Ending Position 67444
Gene Strand (Orientation) +
Protein pI 8.24
Protein Weight 54288.42
Protein Length 526
Protein Note Also known as Tb03.6N20.250
DNA Sequence 
>gi|72387488:65864-67444 Trypanosoma brucei brucei strain 927/4 GUTat10.1 chromosome 3, complete sequence
AATGAAAGCGATTACAACAACAATAGGGACACTATGGATCCTCTCTGCGCATTGGACAAAAGCAGACACA
AATGCAGCGGACAACGAACCAGACTTCACCGTTCTCTGCAGTGTCCTTGACGTAGCTACAGGCAAACCAG
CTCTGAACGACATACCAACTAAATGGAGGAACCTCAGACAACAACTCACAGACATCAATATTAGTCTTTC
CACAGGAGATTGGACAAAGCACCTACTAGACACTGACGGCAATGTACAAGAGTGGACAAAAGCACAGCAA
GCGGGTAAACTGCCAGAGGACTGGGCAACTGAGTGGCCGGCCTGGGCGGCCGCAGCAAAACGCTCAGCAA
AAGGCGGCGAAACGCATGACAAACTCCAAGCAAGTGGGATACCGTCATTAGACGCAGAACAGCGAAAAGA
AGCTGCTCAACTAATAAAACACTTGCTTAACTCGACACAGCCACTCATGGATGCATTACAAGGCGTCGAA
ACAGCCGAAGCAGCAACCACAGCAGCAGCTCTAGCCGCGACACTAGACCAATCTGTCTATGGCGACAAAC
CGGAAGCGCACCCAGGGAAACAGGCATCGGCAGCTGTGAGGCGAACCGCGACACGGGGAATCTGTGCCTC
AGGTGCAAAAATAGGTACAAGCCAAGCGCTAGCAGATGCCTTGCTTTGCCTTTGCTGGACAGACACAGGA
TCGCCACCACAAGGTCAAGGGAGCGTCTGCAGAAAGAACCTCGGCAACACTTTGACGTCAACGTGGGACA
CAGCATCAGCAACCGTCAACGCAGCTTATGCGCAAATAAAAGGGGCATGCAAACTACAAACAGGCCATAC
AATAACAGCCGCCAATATAGCCGAGGCACTAGCAGCAGTTAAGCACAAAATAGCCCAGCACAAGGAAGGC
GGTTACCTCGGCAAATACGAAGGCGACTTCAGCTGCGACGGCAAAAACGCCAACGGAGTCTGCATCAAGT
ACGCAGACTTTTCTGACAAAGGAAACAAAGCTTTCGAGGAAATAGAATGGGTGAAAAAGCTTCGTTCAGT
AGAGACTGCCTTACGCAAGCGAGAAGCAGCGGTGGCACGTGTCGACACTTTAACCACAGCGCTCGAAACG
CAAACAGCTGCAGCCTGGCTTATACCACAACGCGCAAAGAGCAGCCAACAAAAAAGGGAAGGTGTTTCCC
CAAAACAGCACACATCAACAGGCAATGGCAACAAACAACAAGCGGACCAGTGCGAAGCAATAAAGAAAGC
AACTGAGTGCAAAGAAAAACAGCCAAACTGTGAGTGGCAAGGTAAAAATGACGAGGATGGTCCCCACTGC
AAAGTAAATAAAACACACATAACAAAAGAAGCAGCTCAAACAGGAACAAATAGAGGAAATGAAGAGACAA
CAACAGACAAGTGTAGTCAAGCAAAAACCTCTGACGAATGCGCTGCAGTAAAAGGTGATATTCCAAAAGA
TAAAAAATCTGTTTGCGGATGGATAGAAGGAAAGTGTCAGAATTCACGTTTTCCCGTCAATAAGAAATTG
ACTCTAATGGTTTCTGCATTTGTGAGTATTGCAGCATTTTA
Protein Sequence 
>gi|72386443|ref|XP_843646.1| variant surface glycoprotein (VSG) [Trypanosoma brucei TREU927]
MKAITTTIGTLWILSAHWTKADTNAADNEPDFTVLCSVLDVATGKPALNDIPTKWRNLRQQLTDINISLS
TGDWTKHLLDTDGNVQEWTKAQQAGKLPEDWATEWPAWAAAAKRSAKGGETHDKLQASGIPSLDAEQRKE
AAQLIKHLLNSTQPLMDALQGVETAEAATTAAALAATLDQSVYGDKPEAHPGKQASAAVRRTATRGICAS
GAKIGTSQALADALLCLCWTDTGSPPQGQGSVCRKNLGNTLTSTWDTASATVNAAYAQIKGACKLQTGHT
ITAANIAEALAAVKHKIAQHKEGGYLGKYEGDFSCDGKNANGVCIKYADFSDKGNKAFEEIEWVKKLRSV
ETALRKREAAVARVDTLTTALETQTAAAWLIPQRAKSSQQKREGVSPKQHTSTGNGNKQQADQCEAIKKA
TECKEKQPNCEWQGKNDEDGPHCKVNKTHITKEAAQTGTNRGNEETTTDKCSQAKTSDECAAVKGDIPKD
KKSVCGWIEGKCQNSRFPVNKKLTLMVSAFVSIAAF
Molecule Role Virulence factor
Molecule Role Annotation Mutant parasites exhibited markedly reduced infectivity thus demonstrating the importance of specific glycosylation patterns in parasite virulence.
(Castillo-Acosta et al., 2013)
References