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VESA1

Victor ID 5195
Gene Name VESA1
Sequence Strain (Species/Organism) Babesia bovis T2Bo
NCBI Gene ID 5480094
NCBI Protein GI 156088873
Locus Tag BBOV_III007140
Genbank Accession AAXT01000001
Protein Accession XP_001611843
Taxonomy ID 484906
Chromosome No 3
Gene Starting Position 1550672
Gene Ending Position 1553472
Gene Strand (Orientation) +
Protein pI 7.05
Protein Weight 95767.55
Protein Length 898
Protein Note Also known as 17.m10573
DNA Sequence 
>gi|182636838:1550672-1553472 Babesia bovis T2Bo chromosome 3, complete sequence
AATGTCGGCAACATGTAAGACAGGTTCTGATTGTGGCCCAGGTGAGAAATGCCTGACGCAGTGCCCTACC
AATGTTAAGGAAGCTATTGATTGGGTCATATGTATGACCGGCAATGATGGTATGTAGTGATGCGTAGTGT
GTCATTTATTGTTTCAGGTTGCGATTGTCAAAAAGAAAAACTAAAGAGTAAGTATTATACATTCGACTGA
TATTATGTAGCAGATGGTGCGACTGCTTGTGTTGAGAAGGTTGCAAAGGGAGTTGAAGCACTGCTTTCGC
AGTTAAGAAAGGATGGCGATACATCAATCAAGGATGAATGGCCTGATATTGGTGAACTCTCGAAGGATAG
TAACTATGATTCTGGCCAAATTGCTACCTATATAACAGGATTGATTAACTGCCTAGGAGAGAGGTTGTCA
AAATTTCTTGGTTGCACTAAGTGCACGCAAAAACCATCTGGCACATGCCCCCAAAAAGGTACATGTGGAT
TGGTTATCGATAAATATACGTATTGTTATTCTTCCGCATCGGGTTGCTGTATTAATACCAAAGAATCAGA
TCAAATACATTGCGCTAAAATATTATTAGGTTGTATCCCGCTAATATTTTCTTCTTTAACGTACTTGTAC
TGGAACTGCTGTGCTAATGGTAACGGTGGGAAATGGAAGGATTGCCCGTCAACTGATGATTCAACGGGAT
CGTTATGTACTTATTTGGTCACTCTAGGTTACGATACCAATAAACTTAATAAATGTAGTGGAAGTACTAT
CGTATCATTCCTCTCTTGTTTCAAGGAATTGCAAGATTGTTTGGATGTTAAGCAATCGGATAAAAACCCG
AAGTCATATGCAGAATTCGTTAATAAGATTCAGGATTTTTTTTCTAGCACCGAGAAGAAAGAGGGTAAGA
ATATCCCTCTCCAAAGGCTTTACACTGGTGCCTCGGTTTACTTCCAGGCTTTTCAACAAAAGCATAACGA
AAAGGTAGATAAAGCAAAGCGTCCCGAGACTATTTGTGAACTACTGTATTGGTTATTAGGACTACCTTAC
ACTCCGGTGGGTACGCAAGTGGAAAGCGGGTCACTGGAAGTCTTGTTTGACGAAGATGACGATAGCGAAG
ACGATGAGGATAGTGAGGAAAATGAAGTATGTGGTTATTTACCTTCAGAAAAGTGTTGCAAATCACCAGC
TACAAGCAGTGAATGTCGTCTGTCACCTGCAAACGCCGATTCCTTTCTATTACCTCCATGCTACTATTCA
GCATTTGTGCTGATGTCTATACAAGGAAAGCTTCATCCTGGAACAAATACAACTGTTCACCAAGCTTCAT
CCAGCGGAGGAATGGTTACTCAGCAACGTGGACCTTTTCTGCATGACGTATATGCCAATAAACACTTTGA
ATTCTATTACCCATCATTCATTAGAAGCTGGATAGTTACGGTTTGGGATGTAGTATATGCCCTCTATTTC
CAATTAGGGTTCCTCTATAAACAGTGTAAAGTGGACTATGCTACTGGATATGGATGGAAAAATTGTACGT
ATGGTAAGGGTGTTACATGTAATAAGTCACAAACATGGATATGTACGACTTCCCCACCTCAAGGTGCTCA
GCATGGCGAATGCGGAAAAGATACTAATAGGTGTTCGCCCCTTCAAGGTTACTTATGTGATACCCTCACA
GACTTTAAGTGTAAAAATAATGATCAAGAATCCGATTCAAAATCTGAATCCAAAGCGTATTGTGCCCATC
TGAAACATCGCCCATCTTCTCAGTGGTGTCCCATACCAATGGGTTTTGCAAAAAATATGAAACCTATTAC
TCCGGAACGCAAAGGAGAGCATCTCGCTTTAATCTTAACTGCCTACTTTGAAGAGAATACCGATGGTTCA
AGTCTGTATCAATTGGTGTTGTTTGCTGGCATTGTGTCACTTAGACCACCTCGTTGTCTAGGTGATATGT
TTGCTTTTTTTTGTGGTATTGGAAGATTGTGTAATACCAAGCCTGTCCCAAAGAAAGAACTATTAGATAA
TCTTTTGAAAGATACAATGAGTGGGTATCCGGGAACACCTAAACCAGAAGAAATTACGGGACCCTTAAAA
ACATTAGCTGGTAGTTGCACCCAACCATCTCCATCAAAGGGCACTTGTCATAGTCTTTGCAGTTTAAGTC
CTCCAGATGGATCTGCATGCGATTCCTGCACCAAATATATATGCTCTCTTTCTTGGTCAGTATATACGGT
CTTTGCCAAGGAATCTTTCGGATCCTACCTCTCATGGGCTGTTTATCTGATCGACGATTTCCAAACTAAT
CTCAATTGCTTTCTCAAATATTTTGAGAATGTTGAATGTAAATCTGGATGCTCACACTGCACCAATAAAC
ATAAATGCCACGAATTAAACCAGTCCAGTGGATGTCAATGCAAGGTGATTGAATGTAAGGGTATACTTGG
AGCACTGTATAGATTTGGATTCACATATCAGGATGCGGCTACTCTGAAAAGTGTAAAGACTTGCTCCGAT
TTCCTCCAGCAATTGAAAACAGTAACCGATGGAAATCCCTTAAAGGAGCTTATTAGAGCCGTTAACCAGA
TGCTCTATTCAATACGTCTAGCATTTATATTTTGGGCGTGGTTGTTATGGACGGCTGCGATTGTCTACCT
CATCTTTGGACTGGTGGTAGACCTAGACATCCTTCACATCAGATCGCACATTTGGCTGAAGCACACACAC
AATATTCCAGCCTTTAATTTATTCGCGGCCAGGCGCCTTAAATACGGCATACAGGTGTACTTCGGCCGAT
A
Protein Sequence 
>gi|156088873|ref|XP_001611843.1| variant erythrocyte surface antigen-1 family protein [Babesia bovis]
MSATCKTGSDCGPGEKCLTQCPTNVKEAIDWVICMTGNDDGATACVEKVAKGVEALLSQLRKDGDTSIKD
EWPDIGELSKDSNYDSGQIATYITGLINCLGERLSKFLGCTKCTQKPSGTCPQKGTCGLVIDKYTYCYSS
ASGCCINTKESDQIHCAKILLGCIPLIFSSLTYLYWNCCANGNGGKWKDCPSTDDSTGSLCTYLVTLGYD
TNKLNKCSGSTIVSFLSCFKELQDCLDVKQSDKNPKSYAEFVNKIQDFFSSTEKKEGKNIPLQRLYTGAS
VYFQAFQQKHNEKVDKAKRPETICELLYWLLGLPYTPVGTQVESGSLEVLFDEDDDSEDDEDSEENEVCG
YLPSEKCCKSPATSSECRLSPANADSFLLPPCYYSAFVLMSIQGKLHPGTNTTVHQASSSGGMVTQQRGP
FLHDVYANKHFEFYYPSFIRSWIVTVWDVVYALYFQLGFLYKQCKVDYATGYGWKNCTYGKGVTCNKSQT
WICTTSPPQGAQHGECGKDTNRCSPLQGYLCDTLTDFKCKNNDQESDSKSESKAYCAHLKHRPSSQWCPI
PMGFAKNMKPITPERKGEHLALILTAYFEENTDGSSLYQLVLFAGIVSLRPPRCLGDMFAFFCGIGRLCN
TKPVPKKELLDNLLKDTMSGYPGTPKPEEITGPLKTLAGSCTQPSPSKGTCHSLCSLSPPDGSACDSCTK
YICSLSWSVYTVFAKESFGSYLSWAVYLIDDFQTNLNCFLKYFENVECKSGCSHCTNKHKCHELNQSSGC
QCKVIECKGILGALYRFGFTYQDAATLKSVKTCSDFLQQLKTVTDGNPLKELIRAVNQMLYSIRLAFIFW
AWLLWTAAIVYLIFGLVVDLDILHIRSHIWLKHTHNIPAFNLFAARRLKYGIQVYFGR
Molecule Role Virulence factor
Molecule Role Annotation Babesia bovis, an intraerythrocytic parasite of cattle, establishes persistent infections of extreme duration. This is accomplished, at least in part, through rapid antigenic variation of a heterodimeric virulence factor, the variant erythrocyte surface antigen-1 (VESA1) protein.(Xiao et al., 2010)
References
Xiao et al., 2010: Xiao YP, Al-Khedery B, Allred DR. The Babesia bovis VESA1 virulence factor subunit 1b is encoded by the 1beta branch of the ves multigene family. Molecular and biochemical parasitology. 2010; 171(2); 81-88. [PubMed: 20226217].