Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

ornithine decarboxylase

Victor ID 5192
Gene Name ornithine decarboxylase
NCBI Protein GI 159388
Other Database IDs CDD:223098
CDD:143482
Taxonomy ID 5661
Gene Strand (Orientation) ?
Protein Name ornithine decarboxylase
Protein Length 707
Protein Note Diaminopimelate decarboxylase [Amino acid transport and metabolism]; COG0019
Protein Sequence 
>gi|159388|gb|AAA29259.1| ornithine decarboxylase [Leishmania donovani]
MGDHDVALCHVSRYNHANYWAFVPLPTVSDDTGCDSLHHDSASERIRMAPPASASKAGAAEERLHPYERR
LLDQYQIHLQPANRNPLSRADSAAGREETAQTPAQVQMVPVVAVADSTSDQHASVASSQDLVDLFFLEGS
QAVDGLCFSPYPIYGWRTAEERRAAVCEVFKTYNVVTRLPASPAALAAAQRRYSRHRHSAIAPINKSAIE
TREQYWRRLSNLYTQKGVKDAASAADAAATTATNGAVPAAPAYEPEDPFYIIDLGRVVEQMARWRHELPM
VRPYFAVKSNPQPAVLEVLSALGAGFDCASKEEIHMVLGRQLVASPDDIIFANPCKQLGDLREAQACGVT
YVTVDNPLEMEKISRLMPSAHAIIRIKTNDSKAQCSFSTKFGAPLEDVEGLLEAARQFNVTVCGVSFHVG
SGNDDQSAYVSAVRDAYQVFQQAVQYGFKCTILDIGGGFPGTEVVEGSGNTSFEAIARTIRPVLAELFGG
GDVTIISEPGRYFTAASHALLMNVFASRTLRLSDVEVSRQAFQSVVSMDEPEEYQYYVNDGLYHSFNCIL
FDHAHPTLLLLNDGDGADGVESGTEAAAVCSEEEGETSLSGPLANDPLFMSAWDRRRSFARRPLRITTIF
GPTCDSMDCILKKQPFPEMKLGDWLLVPDMGSYTTAAAGFFNGFATRRLEWVSSVDLCARPRPVYTREGN
TLRCVSE
Molecule Role Virulence factor
Molecule Role Annotation a ÃŽâ€ťodc L. donovani null mutant lacking ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, was profoundly compromised in its ability to infect mice, indicating that ODC is essential for the infectious mammalian stage of the parasite and further validating the enzyme as a possible drug target.(Gilroy et al., 2011)
References