Victors

SPDSYN
Victor ID	5191
Gene Name	SPDSYN
NCBI Protein GI	10945607
Other Database IDs	CDD:100107
Taxonomy ID	5661
Gene Strand (Orientation)	?
Protein Name	spermidine synthase
Protein Length	300
Protein Note	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440
Protein Sequence	>gi\|10945607\|gb\|AAG24612.1\| spermidine synthase [Leishmania donovani] MPGPGLLPDGWFREESTMWPGQAQGLKVEKVLYDQPTEFQHLTVFESDPSGPWGTVMTLDGAIQLTDYDE FVYHEMLANLSLTCHHKPERVLIIGGGDGGVVREVLRHKSEKDGIVQSVELVDIDGAVIQQSKKHFPQIA CGFANPCVTATVGDGAAFVKRAPDSVYDVIIIDTTDPKGPASELFGADFYTNVLRILRPGGVLCNQGESV WLHRPLIEMMMGFLKKDIGFATVNYAMIYIPTYPCGSIGTLVCAKSADTDVTVPMRPVESLGFADQLKYY SSDMHKAAFVLPRFAAHLNE
Molecule Role	Virulence factor
Molecule Role Annotation	This ÃŽâ€spdsyn strain was auxotrophic for polyamines, required spermidine for growth in its insect vector form, and was adversely impacted in its ability to infect mice. These findings establish that SPDSYN, like ODC, is essential for maintaining a robust infection in mammals and indicate that pharmacologic inhibition of SPDSYN, and perhaps all components of the polyamine biosynthetic pathway, is a valid therapeutic strategy for the treatment of visceral and, potentially, other forms of leishmaniasis.(Gilroy et al., 2011)
References


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