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SUB

Victor ID 5189
Gene Name SUB
NCBI Protein GI 282192977
Other Database IDs CDD:263972
CDD:173787
Taxonomy ID 5661
Gene Strand (Orientation) ?
Protein Name subtilisin
Protein Length 1744
Protein Note Peptidase domain in the S8 and S53 families; cl10459
Protein Sequence 
>gi|282192977|gb|ADA81891.1| subtilisin [Leishmania donovani]
MEAVVALRLLTIHILAALLLVLPSFPLAEGPWPLSVQAAHRSTDAHAEGPSIHPRKYYLGKYGAHCIRNL
TEFVASEDAAERLACFSGRGVRVALLETGLCAGIAERSRNSVTCTSVVPGVACEDAGCAHGTRSVSVLAG
QLTVSAPLPREPLEETAWRNRETHLALADQYIGLAPDSTVRVLRIFDRQGRTNRRHLARALDLLLREAED
GEAGRLHSAWNTSSAHIRRRDETVDVISLSYGSKDYHSSPQVQDRLYRLMHEHGVIVVAAAGNDGARFGS
VRSPADMPGVLAVGALRMEWHGRSAQTTQASRTLGDLASSLAAGGGHKSVAHFSGRGPTTWELPFGAGRA
KPDLVALGQHVWAVQGVSAAAFSAAAPRARSASPALQLRSASGTSIAAPIVAGVVALCLEAAWSSTSAVA
LAQNMTGGGSFLDVRQNRLARVSDSLRVREVILRTAVPLGEAAASLPPWPHSAPTTPLHSDSSSTASEAH
PRRVLAGVPLLKLYAGYLRLSRVSILSQGAGEVQPLRALHAIVAKAAASSAIDAPEALRNCASFAIPTCV
RIGYRIPRCSNSNSSSSSSSGDMSTPQSCQPPHDPDGKAHGDSPLPGRSGMSLDAPPAAYWWPFSDQAVY
PGATPVLLNISLHLCPPSSPAAADQGTRDAAAAASGKGARRGSTTHIHVTHVITKVSGHVRAREGHPSRN
SSHQCDACPLLFEGAKSRHRAGSTSPTRLLNLTARSASPRASCSDGEVAGEGATVMGPRHTQTAVCSSVK
RWSTQQRWIHHLLRVATELTVVASRSQTRANVVEQLSPPPTSFSLSVAVSSPASAHTHLCYDVARETVAV
WRKKGKSSPASEKDAAAGRRSADGDDGHDKQHSRDGAQVPADHDRCVPLFHLFRALSVEGALHIFTGSSS
SQPALTVPFAVRVVEPPPRVQRVLIDTSLDCFNPTTATSNLFIAGDDPHESDAGGAGAALRRGRQRQRHE
RAYAEASGGDHPFTNLALLYLYLRHTLGMAVETFPLLHMSTIATSIAASHSPPLWPPAERTSNVSRTAQR
APAGTLAHIGTLIIVDPERPLTRGMRRLLTRAVLGGGADRSADGLNVLLVTDWYSADLAAQLHWARDESL
YDAERFSHINGTDATDEVAGADGDRDAVRDLRALRQSENGSTRGLAGSSHVPSWNRWLSEVTVASGSAAN
SSDCDGAAPLGSEGLLDGTSELPFELSESIVIDGAVLVDAAAPRRRSEPEGNAFASHGGTVTSAKVVALR
SLGQLCAAGVLRWRLPAQAAVQRQAGRATAVGASKGVREPNVYPSGNGTCSTGDASNTSAMPSTQEGEAV
ICNVMPSWAQQQRRLVKRTVVSTRDGSAPAAVVEDGWEDVPVANGDGRLVRIGGLEAAEVSTMAPAATGA
SDATQSLTHGVLGFLTLPPSSTLVSTVSANRFRPGRIAIFTDSDCLSASDHHAQAALDELEALLYPPSAS
PSLPVTTCATWDCFSRTPDGQRLLQAESAQSSVCVEVVKELLLWLHTGNLHRWRDSAQLQCEARTWARAR
HRSTADTTPGAGSVLEPKAGEDSVEGDRETANFDELLGTAPERAHVGEVVWRLWASLVESTERDAASFLV
EGPKEGTRFQGDYAAHQESAAANVMRALMVKYHGDWRAHLLDHNVSPPSTGAAGDSYSQSLRPARGRRSG
IATVQQPEQHISLIESLLPLCGMLNALRWLQHPMVLGQLMVSAAVVMSVWLCRAGGGRWRGQRA
Molecule Role Virulence factor
Molecule Role Annotation SUB-deficient Leishmania displayed reduced virulence in both hamster and murine infection models.
(Swenerton et al., 2010)
References