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Ldp27

Victor ID 5188
Gene Name Ldp27
NCBI Protein GI 386686540
Taxonomy ID 5661
Gene Strand (Orientation) ?
Protein Name mitochondrial P27
Protein Length 240
Protein Note cytochrome c oxidase component; involved in oxydative phosphorylation
Protein Sequence 
>gi|386686540|gb|AFJ20648.1| mitochondrial P27 [Leishmania donovani]
MSRCTNKISGGTARANLVDHGVYVKPMSLNPFLGAVHDGTSTGYCQGYSAKPMHWLYRFRYNVLPQGISC
GFFSRNPYGRYVHWLEVSTIEKIRMQLQSVESMPVSVLVTLVVIYSLWFSYRLTFLHPDITLYNLGLWST
KPWVQQQRFNKKIDIDQQVYRWVHRVPEFSITDPIREIYKLEIGANEPYLEHVRGMGREKELTLYANERT
EGAGSIRPLNIRHEDLSGHNPGPLMSGHGV
Molecule Role Virulence factor
Molecule Role Annotation the amastigote-specific protein p27 (Ldp27) is a component of an active cytochrome c oxidase complex in Leishmania donovani and that upon deletion of its gene the parasite had reduced virulence in vivo. genetically modified live attenuated Ldp27(-/-) parasites are safe, induce protective immunity even in the absence of parasites, and can provide protection against homologous and heterologous Leishmania species.(Dey et al., 2010; Dey et al., 2013)
References