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LdASS

Victor ID 5187
Gene Name LdASS
Sequence Strain (Species/Organism) Leishmania donovani
NCBI Gene ID 13389892
NCBI Protein GI 398015484
Locus Tag LDBPK_230300
Genbank Accession FR799610
Protein Accession XP_003860931
Taxonomy ID 5661
Chromosome No 23
Gene Starting Position 96935
Gene Ending Position 98191
Gene Strand (Orientation) ?
Protein pI 5.82
Protein Weight 43176.77
Protein Length 418
DNA Sequence 
>gi|398015803:96935-98191 Leishmania donovani BPK282A1 complete genome, chromosome 23
GATGCCTGCAACGGCGACGGAGGTTGTGTGCGGCAAAAAGCCGAGGGTGGTGCTTGCGTACAGCGGCGGC
CTGGACACGTCTGTGATCATCCCGTGGCTGAAGGAGAACTACGACTATGAGGTGATTGCGTGCTGTGCGA
ACGTTGGGCAGGGTGCCGGTGAGATAGACGGGCTGGAGGAAAAGGCGAAGAAGTCCGGTGCGTCGAAGCT
ATACCTGCTGGACCTGCGTGAGGAGTACGTGACGGACTACATCTTCCCAACGTTGAAAGCTGGCGCGACG
TACGAGGGGAAGTATATGCTGGGGACGTCGCACGCGCGACCCCTGATCGCGAAGCACCTTGTTGAAGTTG
CGCACAAGGAGGGCGCTGTCGCGATCTGCCACGGCGCCACGGGGAAGGGCAACGACCAAGTGCGGTTCGA
GCTGGCGGTCATGGCGCTGGACCCAAGCCTGAAGTGCGTGGCGCCGTGGCGCGAATGGAACATCAAGTCG
CGCGAGGACGCGATCGACTACGCGGAGGCCCATGGCGTCCCTGTACCGTGCACGAAGTCTGACCTGTACT
CGCGCGACCGCAACCTGTGGCACATCAGCCACGAGGGCATGGACCTGGAGGACCCAGCAAACGAGCCGGC
GTACGCGAGGCTTCTGAGGCTGTGCAACACGGTGGAGAAGGCGCCGGACGAGGCGGAGTACGTGACGGTC
CAGTTCGAGAAGGGCATCCCCGTCGCCGTGAACGGCAGAAAAATGTCGAGTGTGGAGCTTGTTGAGGAGC
TGAACGCGCTTGGCGGCAAGCATGCGATCGGGATCGAGGACATCGTGGAGGACCGCCTGGTAGGGATGAA
GTCGCGCGGCGTGTATGAGACACCCGCGGGGACGATCCTGTACAAGGCGCTGGACATGCTGGAGTCGCTG
TGCCTTGACCGTGACACGCAGTCCTTCAAGCGCCAGTCGGCAGTGCGCTTCTCCGAGCTTGTGTACGACG
GCAAGTGGTTTACGCCGCTGCGCGAGTCGATGTCCGCGATGTTCGACCAGATGGCGGAGACGGTGACAGG
CGAGGCGACACTGAAGCTGTACAAAGGTAACCTAGTGCCTGCTGGTGCACAGTCGCCGTACTCGCTGTAC
AACAAGAACATCGCGTCGTTCGGCGACAGCCAACACCTATACAATCACCACGACGCGGAGGGCTTCATCC
GGCTGTTCGGGCTGCCGCTCCGTGTGCGCTCGATGATGAAGGCGAAGGAGATGCCGAGCAGCTTGTG
Protein Sequence 
>gi|398015484|ref|XP_003860931.1| argininosuccinate synthase, putative [Leishmania donovani]
MPATATEVVCGKKPRVVLAYSGGLDTSVIIPWLKENYDYEVIACCANVGQGAGEIDGLEEKAKKSGASKL
YLLDLREEYVTDYIFPTLKAGATYEGKYMLGTSHARPLIAKHLVEVAHKEGAVAICHGATGKGNDQVRFE
LAVMALDPSLKCVAPWREWNIKSREDAIDYAEAHGVPVPCTKSDLYSRDRNLWHISHEGMDLEDPANEPA
YARLLRLCNTVEKAPDEAEYVTVQFEKGIPVAVNGRKMSSVELVEELNALGGKHAIGIEDIVEDRLVGMK
SRGVYETPAGTILYKALDMLESLCLDRDTQSFKRQSAVRFSELVYDGKWFTPLRESMSAMFDQMAETVTG
EATLKLYKGNLVPAGAQSPYSLYNKNIASFGDSQHLYNHHDAEGFIRLFGLPLRVRSMMKAKEMPSSL
Molecule Role Virulence factor
Molecule Role Annotation parasites expressing a mutant form of LdASS associated with a loss of in vitro activity had reduced virulence in vivo in BALB/c mice as demonstrated by a significant reduction in the parasite load in spleen and liver.(Lakhal-Naouar et al., 2012)
References