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CPA

Victor ID 5186
Gene Name CPA
Sequence Strain (Species/Organism) Leishmania infantum JPCM5
NCBI Gene ID 5068524
NCBI Protein GI 146084829
Locus Tag LINJ_19_1460
Genbank Accession FR796451
Protein Accession XP_001465113
Taxonomy ID 435258
Chromosome No 19
Gene Starting Position 615026
Gene Ending Position 616090
Gene Strand (Orientation) ?
Protein pI 7.18
Protein Weight 35812.09
Protein Length 354
DNA Sequence 
>gi|339898013:615026-616090 Leishmania infantum JPCM5 chromosome 19, complete sequence
GATGGCGCGCCGCAACCCCTTTTTTTTTGCGATAGTGGTAACTATCCTGTTCGTGGTGTGCTACGGTTCC
GCTCTTATCGCCCAGACACCTCTCGGCGTCGACGACTTCATTGCCTCGGCGCATTACGGACGCTTTAAGA
AGCGCCACGGCAAGCCCTTCGGCGAGGACGCCGAGGAGGGTCGACGCTTCAACGCCTTCAAGCAGAACAT
GCAGACAGCCTACTTCCTCAATGCGCACAACCCGCACGCGCACTACGACGTGTCCGGCAAGTTCGCGGAC
CTCACCCCGCAGGAGTTCGCCAAGTTGTACCTGAACCCCAACTACTACGCGCGCCACGGCAAGGATTACA
AGGAGCACGTGCACGTCGACGACAGCGTCCGCAGTGGTGTGATGTCGGTGGACTGGCGTGAGAAGGGTGT
CGTGACGCCGGTGAAGAACCAGGGAATGTGCGGCTCGTGCTGGGCCTTCGCCACCACTGGCAACATCGAA
GGCCAGTGGGCTTTAAAAAACCACTCGCTGGTTTCGCTGTCGGAGCAAGTCCTCGTGTCGTGTGACAACA
TCGATGATGGGTGCAACGGCGGGCTGATGCAACAGGCAATGCAATGGATCATCAACGATCACAACGGCAC
TGTGCCCACGGAGGACAGCTACCCCTACACCTCTGCCGGCGGCACGAGGCCTCCGTGCCATGACAACGGC
ACCGTCGGCGCCAAAATAAAAGGTTACATGTCCCTGCCGCATGACGAGGAGGAGATCGCGGCTTATGTAG
GGAAGAACGGCCCAGTCGCCGTCGCCGTCGACGCGACAACCTGGCAGCTGTACTTTGGCGGTGTGGTCAC
CCTCTGCTTCGGGTTGTCGCTCAACCACGGTGTGCTCGTTGTCGGCTTCAACAGACAAGCGAAACCGCCG
TACTGGATCGTGAAGAACTCGTGGGGCTCCTCGTGGGGTGAGAAGGGGTACATCCGCCTTGCCATGGGCA
GCAACCAGTGCTTGCTGAAGAATTACGTCGTGACGGCCACGATTGACGACTCCAACACCTCACACGTGCC
GACGACAGCGGCCTA
Protein Sequence 
>gi|146084829|ref|XP_001465113.1| cysteine peptidase A (CPA) [Leishmania infantum JPCM5]
MARRNPFFFAIVVTILFVVCYGSALIAQTPLGVDDFIASAHYGRFKKRHGKPFGEDAEEGRRFNAFKQNM
QTAYFLNAHNPHAHYDVSGKFADLTPQEFAKLYLNPNYYARHGKDYKEHVHVDDSVRSGVMSVDWREKGV
VTPVKNQGMCGSCWAFATTGNIEGQWALKNHSLVSLSEQVLVSCDNIDDGCNGGLMQQAMQWIINDHNGT
VPTEDSYPYTSAGGTRPPCHDNGTVGAKIKGYMSLPHDEEEIAAYVGKNGPVAVAVDATTWQLYFGGVVT
LCFGLSLNHGVLVVGFNRQAKPPYWIVKNSWGSSWGEKGYIRLAMGSNQCLLKNYVVTATIDDSNTSHVP
TTAA
Molecule Role Virulence factor
Molecule Role Annotation Individual disruption of MIC1 or MIC3 genes slightly reduced virulence in the mouse, whereas doubly depleted parasites were severely impaired in virulence and conferred protection against subsequent challenge. (Denise et al., 2006)
References
Denise et al., 2006: Denise H, Poot J, Jiménez M, Ambit A, Herrmann DC, Vermeulen AN, Coombs GH, Mottram JC. Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5. BMC molecular biology. 2006; 7; 42. [PubMed: 17101050].