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CAP64

Victor ID 5150
Gene Name CAP64
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Gene ID 3253232
NCBI Protein GI 58258997
Locus Tag CNA06800
Genbank Accession AE017341
Protein Accession XP_566911
Taxonomy ID 214684
Chromosome No 1
Gene Starting Position 1856167
Gene Ending Position 1858752
Gene Strand (Orientation) -
Protein pI 6.6
Protein Weight 51037.07
Protein Length 481
DNA Sequence 
>gi|58271746:1856167-1858752 Cryptococcus neoformans var. neoformans JEC21 chromosome 1, complete sequence
GAAGAACTAAGAATGAATAAAAACCGACAGCCCAAGAACAACTGACAGTCTTCGTCGCCAGATGACTGAC
GAGACAAATTGTCTTCCCAGTTTTTTTTATATGGAAAGATGGCCGGGAAAGTCCTCTTCTGTGCTCTACC
ACGATGTATTCTATCCGCACAAAAAATTACAATTCACAGTTCAATATCTTCTAGATACTGCAGCGATAGT
AATAAGTCAGTTTACATCATTGCTACAGAAGGAAAAAACAATAGACTCACCTCATAACAGAGATCAACCT
AAACTCCTTCCCACCCGAAGGATCCGCCGTTTCCTTCAACAACTCACAAGTGAGCTTATGCTCCCCTGGA
GTCAAATTATTCCCAACAGTCGCAGCTCTGGTTGAATGACCATTGTCAGTTCCAAGAAATCTCTAACCGC
GGAATCGCCAGAAAGGAAAATAGTATGATACAACTCACCGTCCAATGTTGTAAGGCTCCTTCCAATACCC
ATCCAACCTCATCGCTTTATCAACATCTTCATCTATCCAGCACTTCACACTTCCCAGATTATATTGGTAC
GACCTCAGATAATGGATTTCGATATTACCGACGGTGGTGGTGAGCTTGAAGGTGATTCGGGAGCCGGGGG
TGTCGGAAATTAGGTAATGTTTCTCTTTCCAATTCCAATTTCGCCTGGCGGAATGGTATTTGGACGTCAG
AATATGGGCTTTAAAAAGAGGAAGAATAGGACTGACCAGCCTTCGTTGGTAACAGGGACGAGAGGATTCT
TCTTGCCGTTGGCCAGGAAACATTGAGGCTTAATGGTAGGGATAACAAGGTCTTTGTCGTACTTCATGTT
GAGTTGCATCTGAATGATTTTCATCAGTATTTACATAACCGCATTTATATACAGTGCAAAGACTCACCCG
AGGGATAGGTTCAAGAGGGTACAGCTGGTCGATGGTCATAGACTTTGCCCCAGGGATGGAAGCCTCAAAT
TTGTCCATTTCACAGAGTTGGGTCTCTATGTAAGCAGCACCAAGTCGACCCATGAGATTGTGACCCTTCT
TGCCCATCTGCAAGGCATCATATCTATCATCAGCTCCTATAATACCTGATATGAAGATGTTATCCGGGAG
CATCTGACGTACATGACGGGTATCGGTTTCTCCATTTCCATGGATATAAAAGTACTCGGGGATGAGGGAC
TCGTTTTGAAGGATGAAATTGTACGCAGCATTTCGGAGAGAGAGAACAGGAGTGTCGTAGAATTGAGCGA
TTCCGTGGTGCTGTTCACCATGATTTCAGTCTGCAAACATATAGGCCAGGTGTTAGGGACCTACCATGTC
TCCACCGTTGGTCACTGTGTTAAATTTCAACGCAAAAATTCTGTTATAAGACATCAACACCTAAACTTGT
CCCAAAGTTTGAAAGACCAACTGGAAGTTCATGACCGCAGGACCATTGGGCAGATCGAGCAGACTTCTGA
CCAGAAGCTCATAAGAATTGATGTTTCGAGTAAGCCTGTTCTTATATCAGTATCCTCTCTCGACACATAA
TGCACTGTGCTCACACTTCATCGTTGATAGCAAGTTCAATGAAGACAAGGTCCATATCGTCCGGCAAGTG
TTCACCATAACATAATGAGAAATAGTCGGTACCTATTCCGTTTTCTTAGAATACTGAATAGCAACAGGTC
CGAAAAAGAAGACGGTACTAACCGACACCACCAACAGCACCATTGATGTATGAGTTCATATTTTCTTCCC
TGCCGTTCTCGCCGACTTTGACGCCGTTGGGAGCAGGAAACAAATTGTTGAGACGATCGAAGACGATACG
GTTGAGGTTTGTGGGGGTGTCAGGAAAATATCCTACGTCCTTGTCGAGACCGAAGCCCTTGGAGACTGCA
AGGTACGGTAATGTATGAGCAAACAGTTGAAGATGGGAGGGAAAGAGGAAAGGAACATGGGACATACCGG
AACCTCCAACAACACCCACTGTGAACCTTTCTCCTCGTCTGAGTTTGGCCAATACTCGTCTTAAACGAGC
GTTAGTCCCTACATAAGCAAGTGCTCGCTGGACATTGTCCTCTCTGAGTCTTTATGTAAGCTACTTAACA
CCCAACCAGCCAGGAGGATGGCCTACCCAAGATCTTCGCACAGTTCGGGGTCGAACTGGCACATTCCACA
GTTACTGTCTTGCTTGACTGCGAAGGCATCCAGAAGCTTGTATGCTTTCTTGCTGGGGAAAAAGAAAGCT
GCGAAAAAGACAATGTTGAGGGCCAAGGAGATGTTCAGAAAGAGCTTGACGCTGCCCCGTGATGCCAGCA
ACATGGTGCCACAGAAGAATTTTAATAGCTATGGTGCCAAAAAGATCGTAGTAGTTATATTACCAGAAAG
ATCGTAGTAGTTATGGTGCCAAAGAGATCGTAGTGGTTACGGTGCCAAAAAGATCTTGTTCGCTATGGTG
CCAAAACGATCTTATTAGCGATTGACGACACTGGCTTTTCAAAGCGCTGGGGAGAAGGGGGTGTCGATCT
TTCCCAGGGCTAGCGGTTTATTCGTGATGGCGCAGACTGTGATGTTTACCAGAGGAAGTTTTCGAT
Protein Sequence 
>gi|58258997|ref|XP_566911.1| CAP64 gene product - related [Cryptococcus neoformans var. neoformans JEC21]
MLLASRGSVKLFLNISLALNIVFFAAFFFPSKKAYKLLDAFAVKQDSNCGMCQFDPELCEDLGEDNVQRA
LAYVGTNARLRRVLAKLRRGERFTVGVVGGSVSKGFGLDKDVGYFPDTPTNLNRIVFDRLNNLFPAPNGV
KVGENGREENMNSYINGAVGGVGTDYFSLCYGEHLPDDMDLVFIELAINDEVLTRNINSYELLVRSLLDL
PNGPAVMNFQIFALKFNTVTNGGDMHHGIAQFYDTPVLSLRNAAYNFILQNESLIPEYFYIHGNGETDTR
HMGKKGHNLMGRLGAAYIETQLCEMDKFEASIPGAKSMTIDQLYPLEPIPRMQLNMKYDKDLVIPTIKPQ
CFLANGKKNPLVPVTNEGWRNWNWKEKHYLISDTPGSRITFKLTTTVGNIEIHYLRSYQYNLGSVKCWID
EDVDKAMRLDGYWKEPYNIGRAATVGNNLTPGEHKLTCELLKETADPSGGKEFRLISVMSI
Molecule Role Virulence factor
Molecule Role Annotation The capsule of Cryptococcus neoformans plays a role in fatal infection in mice. Restoration of the ability to produce a capsule enabled Cryptococcus neoformans strain 602 to cause fatal infection in mice, whereas the strain 602 lacked with capsular remained avirulent.(Chang et al., 1997)
References
Chang et al., 1997: Chang YC, Cherniak R, Kozel TR, Granger DL, Morris LC, Weinhold LC, Kwon-Chung KJ. Structure and biological activities of acapsular Cryptococcus neoformans 602 complemented with the CAP64 gene. Infection and immunity. 1997; 65(5); 1584-1592. [PubMed: 9125534].