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ORF1

Victor ID 5121
Gene Name ORF1
Sequence Strain (Species/Organism) Porcine circovirus 2
NCBI Gene ID 2943186
NCBI Protein GI 38018061
Locus Tag PCV2_gp1
Genbank Accession AY424401
Protein Accession NP_937956
Taxonomy ID 85708
Gene Starting Position 50
Gene Ending Position 994
Gene Strand (Orientation) +
Protein Name replicase
Protein pI 8.34
Protein Weight 33647.36
Protein Length 314
DNA Sequence 
>gi|38018060:50-994 Porcine circovirus 2, complete genome
CATGCCCAGCAAGAAGAATGGAAGAAGCGGACCCCAACCACACAAAAGGTGGGTGTTCACGCTGAATAAT
CCTTCCGAAGACGAGCGCAAGAAAATACGGGAGCTTCCAATCTCCCTTTTTGATTATTTTATTGTTGGCG
AGGAGGGTAATGAGGAAGGACGAACACCCCACCTCCAGGGGTTCGCTAATTTTGTGAAGAAGCAAACATT
TAATAAAGTGAAATGGTATTTCGGTGCCCGCTGCCACATCGAGAAAGCGAAAGGAACTGATCAGCAGAAT
AAAGAATACTGCAGTAAAGAAGGCAACTTACTGATGGAATGTGGAGCTCCTAGATCTCAAGGACAACGGA
GTGACCTGTCTACTGCTGTGAGTACCTTGTTGGAGAGCGGGAGTCTGGTGACCGTTGCAGAGCAGCACCC
TGTAACGTTTGTCAGAAATTTCCGCGGGCTGGCTGAACTTTTGAAAGTGAGCGGGAAAATGCAGAAGCGT
GATTGGAAGACCAATGTACACGTCATTGTGGGGCCACCTGGGTGTGGTAAAAGCAAATGGGCTGCTAATT
TTGCAGACCCGGAAACCACATACTGGAAACCACCTAGAAACAAGTGGTGGGACGGTTACCATGGTGAAGA
AGTGGTTGTTATTGATGACTTTTATGGCTGGCTGCCGTGGGATGATCTACTGAGATTGTGTGATCGATAT
CCATTGACTGTAGAGACTAAAGGTGGAACTGTACCTTTTTTGGCCCGCAGTATTCTGATTACCAGCAATC
AGACCCCGTTGGAATGGTACTCCTCAACTGCTGTCCCAGCTGTAGAAGCTCTCTATCGGAGGATTACTTC
CTTGGTATTTTGGAAGAATGCTACAGAACAATCCACGGAGGAAGGGGGCCAGTTCGTCACCCTTTCCCCC
CCATGCCCTGAATTTCCATATGAAATAAATTACTG
Protein Sequence 
>gi|38018061|ref|NP_937956.1| replicase [Porcine circovirus-2]
MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGNEEGRTPHLQGFANFVKKQTF
NKVKWYFGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLSTAVSTLLESGSLVTVAEQHP
VTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGKSKWAANFADPETTYWKPPRNKWWDGYHGEE
VVVIDDFYGWLPWDDLLRLCDRYPLTVETKGGTVPFLARSILITSNQTPLEWYSSTAVPAVEALYRRITS
LVFWKNATEQSTEEGGQFVTLSPPCPEFPYEINY
Molecule Role Virulence factor
Molecule Role Annotation The chimeric PCV1-2, containing the PCV2 capsid, PCV1 rep, and Ori genes, is attenuated in pigs. Meanwhile, histological lesions of lymphoid and lung tissues, viral loads in lymphoid tissues, viremia, and TNF-α expression in PBMCs were not significantly different between groups PCV2b-Ori1 and PCV2b, suggesting that the Rep gene (ORF1) likely contributes to viral pathogenicity in vivo. (Hua et al., 2013)
References
Hua et al., 2013: Hua T, Wang X, Bai J, Zhang L, Liu J, Jiang P. Attenuation of porcine circovirus type-2b by replacement with the Rep gene of porcine circovirus type-1. Virus research. 2013; 173(2); 270-279. [PubMed: 23454919].