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F14.5L

Victor ID 5106
Gene Name F14.5L
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 4557754
NCBI Protein GI 119223229
Locus Tag VACWR053.5
Genbank Accession M57977
Protein Accession YP_910497
Taxonomy ID 10245
Gene Starting Position 42237
Gene Ending Position 42386
Gene Strand (Orientation) -
Protein Name hypothetical protein
Protein pI 3.63
Protein Weight 4704.07
Protein Length 49
DNA Sequence 
>gi|66275797:42237-42386 Vaccinia virus, complete genome
ATCAATATAGCAACAGTAGTTCTTGCTCCTCCTTGATTCTAGCATCCTCTTCATTATTTTCTTCTACGTA
CATAAGCATGTCCAATACGTTAGACAACACACCGACGATGGCGGCCGCCACAGACACGAATATGACTAGA
CCGATGACCA
Protein Sequence 
>gi|119223229|ref|YP_910497.1| hypothetical protein VACWR053.5 [Vaccinia virus]
MVIGLVIFVSVAAAIVGVLSNVLDMLMYVEENNEEDARIKEEQELLLLY
Molecule Role Virulence factor
Molecule Role Annotation We have shown that insertion of the three vaccinia virus (VACV) promoter-driven foreign gene expression cassettes encoding Renilla luciferase-Aequorea GFP fusion protein, β-galactosidase, and β-glucuronidase into the F14.5L, J2R, and A56R loci of the VACV LIVP genome, respectively, results in a highly attenuated mutant strain GLV-1h68. This strain shows tumor-specific replication and is capable of eradicating tumors with little or no virulence in mice. (Chen et al., 2011)
References
Chen et al., 2011: Chen NG, Yu YA, Zhang Q, Szalay AA. Replication efficiency of oncolytic vaccinia virus in cell cultures prognosticates the virulence and antitumor efficacy in mice. Journal of translational medicine. 2011; 9; 164. [PubMed: 21951588].