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UL23

Victor ID 5102
Gene Name UL23
Sequence Strain (Species/Organism) Bovine herpesvirus 5
NCBI Gene ID 2700720
NCBI Protein GI 296316038
Locus Tag BoHV5_gp34
Genbank Accession AY261359
Protein Accession YP_003662502
Taxonomy ID 35244
Gene Starting Position 64038
Gene Ending Position 67835
Gene Strand (Orientation) +
Protein Name thymidine kinase
Protein pI 6.89
Protein Weight 34817.96
Protein Length 356
Protein Note 2.7.1.21
DNA Sequence 
>gi|123318702:64038-67835 Bovine herpesvirus 5, complete genome
CATGGCCGAGCCGTCTAAGCCCGCGCCCGCCCTCCGCGTCGTGCGCGTCTACCTGGACGGCGCGCACGGG
CTGGGGAAGACGACGACGGGCCGCGCGCTCGCGGCCGCCGCCTCCGCCGCGGGGGGGCCCGTGCTCTTTT
TTCCGGAGCCGATGGCGTACTGGCGCACGATGTTCCCCACGGACGCCTTAAGTGGGATCCTCGCCGCGTC
CGCGCGCCGCGCCGCGGCCCAGGGGGGGCGCGCGGACGCGGACGCGGCCGGCCTGGTCGCGTACTACCAG
GCCCGGTTCGCGGCCCCGTACCTGGTGCTGCACGCGCGCGTGGCCGCGCTGCTGGCGCCGCCTGAGCCGG
CGCCGGGCGGAGACGACGTCGTGACCCTCGTGTTTGACCGGCACCCCCTGGCCGCCTGCCTGTGCTACCC
CTTCGCCCGCTACTGCCTCCGCGAGATCAACGCGGAGGACCTGCTCGCGCTCGCGGCCACCGCGCCCCTC
GAGGCGCCCGGGGCCAACCTCGTCGTGTGCACCCTCCCCCCGGCCGAGCAACAACGCCGCCTGGCGGCGC
GAGCCCGGCCCGGGGACCGCGCGGACGCGGGCTTTCTGGCCGCCGTGCGCAACGCCTACGCGCTCCTGGC
GAACACGTGCGCCTTCCTAGGCGCGGGGGGCGCGTGGCGCGACGGCTGGGACGCGCTGGGGTGGGCGGAC
GCGGACGCGCTGGCCGCGCTCGCGGACCCCCGCGGCGGCGGGCGCGAGCCGGTGCCGGCGCCGGCGCTGC
GCGACACCCTGTTTGCGGCGCTCAAGTGCCGCGAGCTCTACCCCGGCGGCGGGGCGGACCTGCCCGCGGT
CCACGCCTGGGCGCTGGACGCCCTGGCCGACCGCCTTGCGGCCCTCGAGGTCTTCATGCTGGACGTGTCC
GCGGCCCCGGACGCGTGCGCGGCCGCCGTGCTGGGCATGCGGCCCGCCATGCGGGCCGCCCGCGCGGACG
GGGCGGCGGGCGCGACGCTGGCGGACCTGGCGCGCCGGTTCGCGCGGGAGATGACGCCGGGGGGGCCCGA
GGCGGCCCCCAGGGGACTATAAAGCCGCCCCTGCGCCCGCCCGCCCGGTACATTTGCGCGCCGATCGCCC
TCTTGGGACTCGGCGCCCGGCGTTTTTTCCTCGCCCGTCCCCTGCCGCGCAGCGAGCCGCCAAGGAGGAT
GCGGCGCCCGCTTCGCGCGGCGCTCCTGGCGCTGGCCGCGCTCGCGCTCGCCGCGCTCGCCGCGGGCGCC
CCCGCCGGGGGCAAGCGCGGCGAGCGCAAGGGCGGGGACGCGCGGTACGAGGTCGAGGAGTGGGAGATGG
TGGTCGGGGGCGAGTCGGCGGTGCACACGTTCGCCATCCACTGCCTTGGGCCGCGGGGCATCGAGCGCGT
GGCCCACGTCGCGAACCTCAGCCGGCTGCTGGGCGAGTACATCGCGGTTCACGTCGACTTTGCGCGCACC
GCCGGCCGGCGGGACACCATGTTCTTTCTGCCGCGCGCGGCCGCCGCCAACGTCTCGGACGCCGGGATCC
CGGACACCCCGGACGTGCAGTCGCACCCGGGGCTCTTCGGGGTGGCCTTCTCCTGGAGCTACCTGCAGAC
GCGCCACCTCGTGGACTACGACCTGGTGCCGAGCCGGCCCTTGCAGGACTGGTACTTCCCGGGGGCGCGC
AGCGTCGCCCCCGGCGTTAAGGCCAGGGGCGACGCTGCGCACCTGCCGCGCGCTCCGCGCCCCGCGCCGA
CGCCAGTGGGGCGCGCGGCAGCCTTTGACGTCAACGACGTGCTGGCCGGCGGCGCGGAGCACTTTTTCGT
GCCCGCGCGGGCGGACCGCAAGCGGCGCGAGCGCCACGTGGCGGACTTCGCCGCGGTGTGGCCCGTCTCC
TACGTCCCCACGGGCCGGGCCGCGCTCAGCTGCGAGCGGGCCGCGGTCCGGCTGGAGGTGGGGCTCGGCT
TCCTGAGCGTCTCGACGACGTCGCGGGACATCCCGCCCCTGGAGTTCATGGTCACGCCCGCAGACGCCGA
CGTGCGCATGATTACCGCTTTTAACGGGGGCGGCGTTTTCCCGCCGCCCGGGCCCGCGCCCGGGCCGCGG
CGGCGGGCCTACGTGATCGGCTACGGGAGCTCGCGGCTGGACAGCCACATGTACTCGACCATGCGCGAGG
TGGCGTCGTACGCGGACGAGCCCGCCGACTTTCGCGCGCACCTGGCCGCCGCGCACCGGGAGGCCTTCCT
GATGCTCCGGGAGGCGGCGGCTGCGCGCCGCGGGCCCGGGCCGGGCCCCGCGCCGGACGCCGCCTACCAC
GCGTACCGGGTCGCGGCGCGGCTGGGGCTCGCGCTCTCGGCGCTCACCGAGGACGCGCTCGCGGCCGGCT
ACGTGCTCGCGGAGGAGCTGATCGACCTCGACTACCACCTCAAGCTGCTGGCGCGCGTGCTGCTCGGCGC
GGGGCTCGGCTGCGCCGCCGAGGGCCGCGTGCGCGCGCGCACCATCGCGCAGCTGGCCGCGCCCCGCGAG
CTGCGCCCGGACGCGTTCATCCCAGAGCCTGCCGGGGCGGCGCTTGAGAGCGTCGTGGCGCGCGGGCGCA
AGCTGCGCGCCGTGTACGCCTTCTCGGGCCCGGACGCCCCGCCCGCCGCGCGGCGGCTGGCCCACGGCGT
GGTGTCGGACCTCTACGACGCCTTCCTGCGCGGCGAGCTGGCCTGGCGGCCGCCCGCGCGCCACGCGCTC
TTCTTCGCCGTCGCGGCGTCGGCGTTCCCGGCGGACGCGCAGGCGCTGGAGCTCGCGCGGGACGTGGCGC
GCAAGTGCACGGCCATGTGCACCGCCGGCCACGCCACGGCGGCCGCCCTGGACCTGGAGGAGGCGTACGC
GCGCGCCGGCGCGCCCGGGGCCGCCGGCGCGGACTTTGAGCTGCTGGACGCCTTCTCGCCGTGCATGGCC
TCATTCCGCCTGGACCTGCTCGAGGAGGCGCACGTGCTGGACGTGCTCTCGGCCGTGCCCGCGCGGGCCG
CGCTGGACGCCTGGCTGGAGGTGCGGCCCGCGGCCGCGGCGCCGAACCTCAGCGCCGCGGCGCTTGGCAT
GCTGGGCCGGGGGGCCCTCTTCGGGCGGGCGCACGCCGCTGCGCTCGCGCCCGAGCTCTTCGCGGCGCCC
TGCGGCGGGTGGGGCGCGGGCGCCGCCGTGGCGATCGTCCCCGTGGCGCCGAACGCCAGCTACGTGCTCA
CGCGCGCGCACCCGCGGCGCGGGCTGACGTACACCCTCCAGGGGATCGACGTCGCCAACCCCCTGCTGGT
GACCTTTGTGCGCGGCGCGTCGTGCGTGTCGGCCAGCGGCGCCGTGGAGGCGCGCCGCCTCCCGGTCCCC
GGCCCGCTCGACGCGTGCGCCTACTGCGGCAGCGTGTTCGTGCGGTATCTGCCCTCGGGGGCCGTCATGG
ACATCGTGCTCATCGCGGACAAGCGCGCCGAGGTCGAGTTTGCGCGCGGCGCCAACTCCAGCATGCCCGT
CTTCAACCCCCGCCTCCACAGCGGCCGCTCCCGCGCCCTGCTGCTGTTCCCCAACGGGACGGTCGTGAGC
GTGCTGGCCTTTGCCGGGCACGAGGCGCCGAGCTTCTCGCCGGCGTACGTCTGGGCTTCGGTGGCCGGGG
CGCTGGTCGCGGGTGCCACGATGTTCGTCATCACGAAGATGCTGTGCAGCTCGGTTCCGATCGCGCGCGG
GTACTCGGCCGTCCCGGCGTTCTAGCGCGCGCCCGGAGGCCCCTCCGCTATCCCCGGCTCCCACCCCACC
CCCTGCGGTTTCCAATAA
Protein Sequence 
>gi|296316038|ref|YP_003662502.1| thymidine kinase [Bovine herpesvirus 5]
MAEPSKPAPALRVVRVYLDGAHGLGKTTTGRALAAAASAAGGPVLFFPEPMAYWRTMFPTDALSGILAAS
ARRAAAQGGRADADAAGLVAYYQARFAAPYLVLHARVAALLAPPEPAPGGDDVVTLVFDRHPLAACLCYP
FARYCLREINAEDLLALAATAPLEAPGANLVVCTLPPAEQQRRLAARARPGDRADAGFLAAVRNAYALLA
NTCAFLGAGGAWRDGWDALGWADADALAALADPRGGGREPVPAPALRDTLFAALKCRELYPGGGADLPAV
HAWALDALADRLAALEVFMLDVSAAPDACAAAVLGMRPAMRAARADGAAGATLADLARRFAREMTPGGPE
AAPRGL
Molecule Role Virulence factor
Molecule Role Annotation The recombinants are defective in glycoprotein E (BoHV-5gEDelta), thymidine kinase (BoHV-5TKDelta) and both proteins (BoHV-5gEDeltaTKDelta). Rabbits inoculated with the recombinants BoHV-5TKDelta (N = 8) or BoHV-5gEDeltaTKDelta (N = 8) remained healthy throughout the experiment in spite of variable levels of virus replication in the nose.(Silva et al., 2010)
References
Silva et al., 2010: Silva SC, Brum MC, Weiblen R, Flores EF, Chowdhury SI. A bovine herpesvirus 5 recombinant defective in the thymidine kinase (TK) gene and a double mutant lacking TK and the glycoprotein E gene are fully attenuated for rabbits. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.]. 2010; 43(2); 150-159. [PubMed: 20027480].