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gE

Victor ID 5101
Gene Name gE
NCBI Nucleotide GI 6983968
NCBI Protein GI 6983969
Protein Accession AAF34744.1
Other Database IDs CDD:251322
Taxonomy ID 35244
Gene Strand (Orientation) ?
Protein Name glycoprotein E
Protein Length 598
Protein Note Alphaherpesvirus glycoprotein E; pfam02480
DNA Sequence 
>gi|6983968|gb|AF208294.1| Bovine herpesvirus 5 glycoprotein E gene, complete cds
GGCTGTTAAATTGGTTTCGCGCGGCTCGCTGTCTTACACCGCGTTGGAGGACCAGCGCGAGCTCCGCCGC
GCGCCCCGCGAGCGAGCCGAGTTCCGTGAGACAGCGCGCGCGAGAGGAACTGAGAGAAGCGTCTGGCGAT
GCGGGCCACCGCGCCGCCCCGGCCGCGGCTGCTGCCGCTGCTGCTGCCGCTGCTGCTGCCGCCGTCGCTC
CTCGGGCTACCGGTCGGGGCCGGCCTTGGCCCCAGCCCCAGCCCCGAAGCCGACACCGGGGCAAAGGCCC
CGGCCGGCGCGGTCTTCACCGCGCGCGTTGGTGCGCCCGTCTTCCTCCCTGGGCCTGACCCGCGCCCCGA
GACGCGCGCCGTTCGCGGCTGGAGCGTCCTCGCGAGCGACTGCCCGCCGCCCGAGCCGACGCCCGTCTGC
CTCGACGACCGCGAGTGCTTCGCCGACGTGGCCCTGGACGCGGCCTGCCTGCGGACCGCTCGCATGGCCC
CGCTGGCCATCGCAGAGCTCACCGAGCGGCCCGATCCGGCGGGCGACAGGGAGTTCGTCGTCCCTGACCC
GCGCGTTTCCGCGCGGCTGGGCCGCAACGCGACCGGGGTGCAGATCGCGGACGTGACCGAGGAGGACGGC
GGCGTGTACTTCCTGTACGACCGGGCCGCCGGCGACGCCGGCGACGAGGAGACGCAGTCGGCCCTGACGC
TGCGCGTCGAGCCGGCCGACGCTTGGGACCCCGCCGGGCAGGGCGAGGGCGGGGAAGGGGAAGGGGGGAA
GGGGGGGCGAGGGGCGGCCAAGCCCACCCCCACCCCCGCCCCCAGCCCGCCCCGCCCCACGCCCGCGCGC
CCCGCGCCCCCCCCGCGGCGGCGGCACGGCGCGCGCTTCCGCGTGCAGCCGTACCGCTCCCACGTGTACA
CCCCGGGCGACTCCTTCACGCTCTCGGTGCGGCTGCAGTCCGAGTTCTTCGACGAGGCGCCGTTCTCGGC
CAGCATCGACTGGTATTTTTTGCGGCCGGCTGGCGACTGCGCGCTCGTCCGCATCTACGAGACGTGCATC
TTCCACCCCGAGGCGCCGGCCTGCCTGCACCCGGTCGACGCGCGGTGCGCCTTCGCGTCGCCCTACCGCT
CCGAGACCGCGTACAGCCGGCTGTACGAGCGGTGCCGCCCAGCCTCCGCCGACCGCTGGCCGCGCGAGTG
CGAAGGCGCTGCGTACGAGGCCCCCGTCGCACACTTGCGCCCCGCCAACAACAGCGTGGACCTAGTCTTT
GACGGCGCGCCGGCCTCGGCCTCGGGGCTCTACGTCTTCGTGCTGCAGTACAACGGCCACGTGGAGGCCC
TGGGACTACAGCCCTGGTCGTCACCTCGGACCGCCCTGGTGCGCGCCGTCACCGACCACACGCGCCCCGC
GGCCGCCGACGCCCCCGAGCCGAGCCCGCCGCCCGCCGACGGGCCGGCGGACGCGCCCGGCAGGGGCGCG
CGCGGCCCCGCGCCCTGGCTCGTGGTGCTGGGGGGCGCGCTCGGGCTCGCGGGCCTAATCGGCGTCGCGG
CCCTCGCCGTCTGGGTGTGCGCGCGCCGCGCGGGCCAGAAGCGCACCTACGACATCCTCAACCCCTTCGG
GCCGGTGTACACCAGCCTGCCGACCAACGAGCCGCTCGACGTGGTGTCGGTCAGCGACGACGAGTTTTTC
CCCGACGAGGACTCTTCCTTCGCGGAGGACGGCAGCGACGCCGACGACGAGCTCGCCGACGAGCCCCCCG
CCACCGCCGCCTACGACCTCGCCGGGCCCGCCCGGGAGGCCGGCGGGCCCGCGCGCCCGAGCCGCTCGGG
CTTCAAGGTCTGGTTCAGGGACCCGCTCGAGGACGACGATGTCGCGCCGGCGCGGCCCCAGACCGCGCCG
GACTACACCGTGGTGGCGGCGCGGCTGAAGTCCATCCTCCGCTAGGCGCCCCTCCCGGCCCCGCGTTGCC
CGGCGCGGGGACCCCGCGTATAAATTCGGCGGCGGCGCGGGGCCCCGCGCG
Protein Sequence 
>gi|6983969|gb|AAF34744.1| glycoprotein E [Bovine herpesvirus 5]
MRATAPPRPRLLPLLLPLLLPPSLLGLPVGAGLGPSPSPEADTGAKAPAGAVFTARVGAPVFLPGPDPRP
ETRAVRGWSVLASDCPPPEPTPVCLDDRECFADVALDAACLRTARMAPLAIAELTERPDPAGDREFVVPD
PRVSARLGRNATGVQIADVTEEDGGVYFLYDRAAGDAGDEETQSALTLRVEPADAWDPAGQGEGGEGEGG
KGGRGAAKPTPTPAPSPPRPTPARPAPPPRRRHGARFRVQPYRSHVYTPGDSFTLSVRLQSEFFDEAPFS
ASIDWYFLRPAGDCALVRIYETCIFHPEAPACLHPVDARCAFASPYRSETAYSRLYERCRPASADRWPRE
CEGAAYEAPVAHLRPANNSVDLVFDGAPASASGLYVFVLQYNGHVEALGLQPWSSPRTALVRAVTDHTRP
AAADAPEPSPPPADGPADAPGRGARGPAPWLVVLGGALGLAGLIGVAALAVWVCARRAGQKRTYDILNPF
GPVYTSLPTNEPLDVVSVSDDEFFPDEDSSFAEDGSDADDELADEPPATAAYDLAGPAREAGGPARPSRS
GFKVWFRDPLEDDDVAPARPQTAPDYTVVAARLKSILR
Molecule Role Virulence factor
Molecule Role Annotation The recombinants are defective in glycoprotein E (BoHV-5gEDelta), thymidine kinase (BoHV-5TKDelta) and both proteins (BoHV-5gEDeltaTKDelta). Three of 8 rabbits inoculated with the recombinant BoHV-5gEDelta developed neurological signs between days 10 and 15 pi and were also euthanized. (Silva et al., 2010)
References
Silva et al., 2010: Silva SC, Brum MC, Weiblen R, Flores EF, Chowdhury SI. A bovine herpesvirus 5 recombinant defective in the thymidine kinase (TK) gene and a double mutant lacking TK and the glycoprotein E gene are fully attenuated for rabbits. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.]. 2010; 43(2); 150-159. [PubMed: 20027480].